Discontinuous vs. continuous drinking of ethanol in peripubertal rats : effect on 24-hour pattern of hypophyseal-gonadal axis activity and anterior pituitary oxidative stress
Abstract: Aims. Discontinuous (weekend) consumption of alcohol is common in adolescents and young adults. This study therefore assesses, in peripubertal male rats, the effect of discontinuous as compared to chronic feeding of ethanol or control liquid diet. Methods. Animals received an ethanol l...
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Formato: | Artículo |
Lenguaje: | Inglés Inglés |
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Karger Publishers
2019
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Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/1662 |
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I33-R139123456789-1662 |
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institution |
Universidad Católica Argentina |
institution_str |
I-33 |
repository_str |
R-139 |
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Repositorio Institucional de la Universidad Católica Argentina (UCA) |
language |
Inglés Inglés |
topic |
ALCOHOLISMO REPRODUCCION HUMANA PROLACTINA LIBIDO STRESS RITMO CIRCADIANO |
spellingShingle |
ALCOHOLISMO REPRODUCCION HUMANA PROLACTINA LIBIDO STRESS RITMO CIRCADIANO Fernández Mateos, María P. Jiménez Ortega, Vanesa Cano Barquilla, Pilar Cardinali, Daniel Pedro Esquifino, Ana I. Discontinuous vs. continuous drinking of ethanol in peripubertal rats : effect on 24-hour pattern of hypophyseal-gonadal axis activity and anterior pituitary oxidative stress |
topic_facet |
ALCOHOLISMO REPRODUCCION HUMANA PROLACTINA LIBIDO STRESS RITMO CIRCADIANO |
description |
Abstract: Aims. Discontinuous (weekend) consumption of alcohol is common in adolescents
and young adults. This study therefore assesses, in peripubertal male rats, the
effect of discontinuous as compared to chronic feeding of ethanol or control liquid
diet.
Methods. Animals received an ethanol liquid diet (6.2 % wt/vol) starting on day
35 of life. Every week for 5 weeks, the discontinuous ethanol group received the
ethanol diet for 3 consecutive days and the control liquid diet for 4 days. At the 5th
week, 24 h after the last ethanol administration to the discontinuous ethanol
treated animals, rats were killed at 4 h intervals beginning at 0900 h. Chronically
administered rats received the ethanol diet until immediately before study.
Results. Disrupted 24-h rhythmicity together with a significant nocturnal increase
in plasma luteinizing hormone (LH), testosterone and prolactin (PRL) occurred in
the discontinuous ethanol group. Plasma ethanol levels were undetectable at 24 h
after the last ethanol treatment. In contrast, after chronic ethanol administration,
plasma PRL was increased late in scotophase while LH and testosterone decreased;
blood ethanol levels were 2-fold greater than those in discontinuously ethanoladministered rats killed immediately after ethanol withdrawal. Circulating
testosterone positively correlated with LH levels in control rats only. Chronic
administration of ethanol significantly augmented mean expression of pituitary
nitric oxide synthase (NOS)-2, heme oxygenase (HO)-1, Per1 and Per2 genes and
disrupted their diurnal rhythmicity. Decreased NOS-1 and NOS-2 expression during
scotophase, together with suppression of the rhythm in Per1 and Per2 expression,
were found in the discontinuous ethanol group.
Conclusions. Abstinence after discontinuous drinking of alcohol in rats, as
compared to chronic administration of ethanol, is accompanied by increases of
plasma LH and testosterone, a greater PRL response and a less pronounced
oxidative damage of the anterior pituitary. |
format |
Artículo |
author |
Fernández Mateos, María P. Jiménez Ortega, Vanesa Cano Barquilla, Pilar Cardinali, Daniel Pedro Esquifino, Ana I. |
author_facet |
Fernández Mateos, María P. Jiménez Ortega, Vanesa Cano Barquilla, Pilar Cardinali, Daniel Pedro Esquifino, Ana I. |
author_sort |
Fernández Mateos, María P. |
title |
Discontinuous vs. continuous drinking of ethanol in peripubertal rats : effect on 24-hour pattern of hypophyseal-gonadal axis activity and anterior pituitary oxidative stress |
title_short |
Discontinuous vs. continuous drinking of ethanol in peripubertal rats : effect on 24-hour pattern of hypophyseal-gonadal axis activity and anterior pituitary oxidative stress |
title_full |
Discontinuous vs. continuous drinking of ethanol in peripubertal rats : effect on 24-hour pattern of hypophyseal-gonadal axis activity and anterior pituitary oxidative stress |
title_fullStr |
Discontinuous vs. continuous drinking of ethanol in peripubertal rats : effect on 24-hour pattern of hypophyseal-gonadal axis activity and anterior pituitary oxidative stress |
title_full_unstemmed |
Discontinuous vs. continuous drinking of ethanol in peripubertal rats : effect on 24-hour pattern of hypophyseal-gonadal axis activity and anterior pituitary oxidative stress |
title_sort |
discontinuous vs. continuous drinking of ethanol in peripubertal rats : effect on 24-hour pattern of hypophyseal-gonadal axis activity and anterior pituitary oxidative stress |
publisher |
Karger Publishers |
publishDate |
2019 |
url |
https://repositorio.uca.edu.ar/handle/123456789/1662 |
work_keys_str_mv |
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Repositorios |
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