Melatonin agonists for treatment of sleep and depressive disorders

Abstract: Melatonin the hormone secreted by the pineal gland has been effective in improving sleep both in normal sleepers and insomniacs and has been used successfully in treating sleep and circadian rhythm sleep disorders. The lack of consistency in the reports published by the authors is attribut...

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Autores principales: Srinivasan, Venkataramanujan, Cardinali, Daniel Pedro, Pandi Perumal, Seithikurippu R., Brown, Gregory M.
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: GESDAV Foundation 2019
Materias:
MELATONINA
AGONISTAS
ANTIDEPRESIVOS
TRASTORNO DEPRESIVO MAYOR
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1660
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1660
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic MELATONINA
AGONISTAS
ANTIDEPRESIVOS
TRASTORNO DEPRESIVO MAYOR
spellingShingle MELATONINA
AGONISTAS
ANTIDEPRESIVOS
TRASTORNO DEPRESIVO MAYOR
Srinivasan, Venkataramanujan
Cardinali, Daniel Pedro
Pandi Perumal, Seithikurippu R.
Brown, Gregory M.
Melatonin agonists for treatment of sleep and depressive disorders
topic_facet MELATONINA
AGONISTAS
ANTIDEPRESIVOS
TRASTORNO DEPRESIVO MAYOR
description Abstract: Melatonin the hormone secreted by the pineal gland has been effective in improving sleep both in normal sleepers and insomniacs and has been used successfully in treating sleep and circadian rhythm sleep disorders. The lack of consistency in the reports published by the authors is attributed to the differential bioavailabilty and short half-life of melatonin. Sleep disturbances are also prominent features of depressive disorders. To overcome this problem, melatonergic agonists with sleep promoting properties have been introduced in clinical practice. Ramelteon, the MT1/ MT2 melatonergic agonist, has been used in a large number of clinical trials involving chronic insomniacs and has been found effective in improving the total sleep time and sleep efficiency of insomniacs and has not manifested serious adverse effects. The development of another MT1/MT2 melatonergic agonist agomelatine with antagonsim to 5-HT2c serotonin receptors has been found useful not only in treating sleep problems of patients but also as a first line antidepressant with earlier onset of actions in patients with major depressive disorder. An agonist for MT3 melatonin receptor has also been found effective in animal models of depression.
format Artículo
author Srinivasan, Venkataramanujan
Cardinali, Daniel Pedro
Pandi Perumal, Seithikurippu R.
Brown, Gregory M.
author_facet Srinivasan, Venkataramanujan
Cardinali, Daniel Pedro
Pandi Perumal, Seithikurippu R.
Brown, Gregory M.
author_sort Srinivasan, Venkataramanujan
title Melatonin agonists for treatment of sleep and depressive disorders
title_short Melatonin agonists for treatment of sleep and depressive disorders
title_full Melatonin agonists for treatment of sleep and depressive disorders
title_fullStr Melatonin agonists for treatment of sleep and depressive disorders
title_full_unstemmed Melatonin agonists for treatment of sleep and depressive disorders
title_sort melatonin agonists for treatment of sleep and depressive disorders
publisher GESDAV Foundation
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1660
work_keys_str_mv AT srinivasanvenkataramanujan melatoninagonistsfortreatmentofsleepanddepressivedisorders
AT cardinalidanielpedro melatoninagonistsfortreatmentofsleepanddepressivedisorders
AT pandiperumalseithikurippur melatoninagonistsfortreatmentofsleepanddepressivedisorders
AT browngregorym melatoninagonistsfortreatmentofsleepanddepressivedisorders
bdutipo_str Repositorios
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