Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats

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Abstract: The objective of the present study was to evaluate the efficacy of melatonin to affect mild inflammation in the metabolic syndrome (MS) induced by a high-fat diet in rats. Adult Wistar male rats were divided into four groups (n= 16/group): (i) control diet (3% fat); (ii) high-fat (35%) die...

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Autores principales: Cano Barquilla, Pilar, Pagano, Eleonora Samanta, Jiménez Ortega, Vanesa, Fernández Mateos, Pilar, Esquifino, Ana I., Cardinali, Daniel Pedro
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: 2019
Materias:
DISLIPIDEMIA
TOLERANCIA A LA GLUCOSA
DIETA
HIPERTENSION
INFLAMACION
ACIDO URICO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1657
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1657
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic DISLIPIDEMIA
TOLERANCIA A LA GLUCOSA
DIETA
HIPERTENSION
INFLAMACION
ACIDO URICO
spellingShingle DISLIPIDEMIA
TOLERANCIA A LA GLUCOSA
DIETA
HIPERTENSION
INFLAMACION
ACIDO URICO
Cano Barquilla, Pilar
Pagano, Eleonora Samanta
Jiménez Ortega, Vanesa
Fernández Mateos, Pilar
Esquifino, Ana I.
Cardinali, Daniel Pedro
Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats
topic_facet DISLIPIDEMIA
TOLERANCIA A LA GLUCOSA
DIETA
HIPERTENSION
INFLAMACION
ACIDO URICO
description Abstract: The objective of the present study was to evaluate the efficacy of melatonin to affect mild inflammation in the metabolic syndrome (MS) induced by a high-fat diet in rats. Adult Wistar male rats were divided into four groups (n= 16/group): (i) control diet (3% fat); (ii) high-fat (35%) diet; (iii) high-fat diet + melatonin; (iv) melatonin. Rats had free access to high-fat or control chow and one of the following drinking solutions for 10 weeks: (a) tap water; (b) 25 μg/mL of melatonin. Plasma interleukin (IL)-1β, IL-4, IL-6, IL-10, tumor necrosis factor (TNF)-α, interferon (IFN)-γ and C-reactive protein (CRP) were measured at two time intervals, i.e. the middle of daylight period and the middle of the scotophase. In addition, a number of somatic and metabolic components employed clinically to monitor the MS were measured. Melatonin decreased the augmented circulating levels of IL-1β, IL-6, TNF-α, IFN-γ and CRP seen in obese rats and restored the depressed levels of IL-4 and IL-10. Rats fed with the high-fat diet showed significantly higher body weights and augmented systolic blood pressure from the 3rd and 4th week onwards, respectively, melatonin effectively preventing these changes. In high-fat fed rats circulating low-density lipoprotein-cholesterol, total cholesterol and triglyceride concentration augmented significantly, melatonin being effective to counteract these changes. Melatonin-treated rats showed a decreased insulin resistance, the highest values of plasma high-density lipoprotein-cholesterol and the lowest values of plasma uric acid. The results indicate that melatonin is able to normalize the altered biochemical proinflammatory profile seen in rats fed with a high-fat diet
format Artículo
author Cano Barquilla, Pilar
Pagano, Eleonora Samanta
Jiménez Ortega, Vanesa
Fernández Mateos, Pilar
Esquifino, Ana I.
Cardinali, Daniel Pedro
author_facet Cano Barquilla, Pilar
Pagano, Eleonora Samanta
Jiménez Ortega, Vanesa
Fernández Mateos, Pilar
Esquifino, Ana I.
Cardinali, Daniel Pedro
author_sort Cano Barquilla, Pilar
title Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats
title_short Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats
title_full Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats
title_fullStr Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats
title_full_unstemmed Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats
title_sort melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1657
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