Non-motor symptoms groups in Parkinson's disease patients : results of a pilot, exploratory study

Abstract: Nonmotor symptoms (NMS) like neuropsychiatric symptoms, sleep disturbances or autonomic symptoms are a common feature of Parkinson’s disease (PD). To explore the existence of groups of NMS and to relate them to PD characteristics, 71 idiopathic non-demented PD out-patients were recruited...

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Autores principales: Pérez Lloret, Santiago, Rossi, Malco Damián, Merello, Marcelo, Rascol, Olivier, Cardinali, Daniel Pedro
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Hindawi 2019
Materias:
ENFERMEDAD DE PARKINSON
SINTOMAS NO MOTORES
TRATAMIENTO FARMACOLOGICO
ENFERMEDADES NEUROGENERATIVAS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1654
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1654
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic ENFERMEDAD DE PARKINSON
SINTOMAS NO MOTORES
TRATAMIENTO FARMACOLOGICO
ENFERMEDADES NEUROGENERATIVAS
spellingShingle ENFERMEDAD DE PARKINSON
SINTOMAS NO MOTORES
TRATAMIENTO FARMACOLOGICO
ENFERMEDADES NEUROGENERATIVAS
Pérez Lloret, Santiago
Rossi, Malco Damián
Merello, Marcelo
Rascol, Olivier
Cardinali, Daniel Pedro
Non-motor symptoms groups in Parkinson's disease patients : results of a pilot, exploratory study
topic_facet ENFERMEDAD DE PARKINSON
SINTOMAS NO MOTORES
TRATAMIENTO FARMACOLOGICO
ENFERMEDADES NEUROGENERATIVAS
description Abstract: Nonmotor symptoms (NMS) like neuropsychiatric symptoms, sleep disturbances or autonomic symptoms are a common feature of Parkinson’s disease (PD). To explore the existence of groups of NMS and to relate them to PD characteristics, 71 idiopathic non-demented PD out-patients were recruited. Sleep was evaluated by the PD Sleep Scale (PDSS). Several neuropsychiatric, gastrointestinal and urogenital symptoms were obtained from the NMSQuest. Sialorrhea or dysphagia severity was obtained from the Unified PD Rating Scale activities of daily living section. MADRS depression scale was also administered. Exploratory factor analysis revealed the presence of 5 factors, explaining 70% of variance. The first factor included PDSS measurement of sleep quality, nocturnal restlessness, off-related problems and daytime somnolence; the second factor included nocturia (PDSS) and nocturnal activity; the third one included gastrointestinal and genitourinary symptoms; the forth one included nocturnal psychosis (PDSS), sialorrhea and dysphagia (UPDRS); and the last one included the MADRS score as well as neuropsychiatric symptoms. Sleep disorders correlated with presence of wearing-off, nocturia with age >69 years, and nocturnal psychosis with levodopa equivalent dose or UPDRS II score. Neuropsychiatric symptoms correlated with UPDRS II+III score and non-tricyclic antidepressants. These results support the occurrence of significant NMS grouping in PD patients.
format Artículo
author Pérez Lloret, Santiago
Rossi, Malco Damián
Merello, Marcelo
Rascol, Olivier
Cardinali, Daniel Pedro
author_facet Pérez Lloret, Santiago
Rossi, Malco Damián
Merello, Marcelo
Rascol, Olivier
Cardinali, Daniel Pedro
author_sort Pérez Lloret, Santiago
title Non-motor symptoms groups in Parkinson's disease patients : results of a pilot, exploratory study
title_short Non-motor symptoms groups in Parkinson's disease patients : results of a pilot, exploratory study
title_full Non-motor symptoms groups in Parkinson's disease patients : results of a pilot, exploratory study
title_fullStr Non-motor symptoms groups in Parkinson's disease patients : results of a pilot, exploratory study
title_full_unstemmed Non-motor symptoms groups in Parkinson's disease patients : results of a pilot, exploratory study
title_sort non-motor symptoms groups in parkinson's disease patients : results of a pilot, exploratory study
publisher Hindawi
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1654
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AT merellomarcelo nonmotorsymptomsgroupsinparkinsonsdiseasepatientsresultsofapilotexploratorystudy
AT rascololivier nonmotorsymptomsgroupsinparkinsonsdiseasepatientsresultsofapilotexploratorystudy
AT cardinalidanielpedro nonmotorsymptomsgroupsinparkinsonsdiseasepatientsresultsofapilotexploratorystudy
bdutipo_str Repositorios
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