Melatonin : a pleiotropic, orchestrating regulator molecule

Abstract: Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues and cells. It acts via G protein-coupled receptors expressed in various areas of the central nervous system and in peripheral tissues. Parallel signaling mechanisms lead to cell-specific control and...

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Autores principales: Srinivasan, Venkataramanujan, Pandi Perumal, Seithikurippu R., Brown, Gregory M., Cardinali, Daniel Pedro, Spence, David Warren, Hardeland, Rüdiger
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Elsevier 2019
Materias:
MELATONINA
SUEÑO
ENVEJECIMIENTO
DIABETES
MITOCONDRIOS
RITMO CIRCADIANO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1653
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1653
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic MELATONINA
SUEÑO
ENVEJECIMIENTO
DIABETES
MITOCONDRIOS
RITMO CIRCADIANO
spellingShingle MELATONINA
SUEÑO
ENVEJECIMIENTO
DIABETES
MITOCONDRIOS
RITMO CIRCADIANO
Srinivasan, Venkataramanujan
Pandi Perumal, Seithikurippu R.
Brown, Gregory M.
Cardinali, Daniel Pedro
Spence, David Warren
Hardeland, Rüdiger
Melatonin : a pleiotropic, orchestrating regulator molecule
topic_facet MELATONINA
SUEÑO
ENVEJECIMIENTO
DIABETES
MITOCONDRIOS
RITMO CIRCADIANO
description Abstract: Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues and cells. It acts via G protein-coupled receptors expressed in various areas of the central nervous system and in peripheral tissues. Parallel signaling mechanisms lead to cell-specific control and recruitment of downstream factors, including various kinases, transcription factors and ion channels. Additional actions via nuclear receptors and other binding sites are likely. By virtue of high receptor density in the circadian pacemaker, melatonin is involved in the phasing of circadian rhythms and sleep promotion. Additionally, it exerts effects on peripheral oscillators, including phase coupling of parallel cellular clocks based on alternate use of core oscillator proteins. Direct central and peripheral actions concern the up- or downregulation of various proteins, among which inducible and neuronal NO synthases seem to be of particular importance for antagonizing inflammation and excitotoxicity. The methoxyindole is also synthesized in several peripheral tissues, so that the total content of tissue melatonin exceeds by far the amounts in the circulation. Emerging fields in melatonin research concern receptor polymorphism in relation to various diseases, the control of sleep, the metabolic syndrome, weight control, diabetes type 2 and insulin resistance, and mitochondrial effects. Control of electron flux, prevention of bottlenecks in the respiratory chain and electron leakage contribute to the avoidance of damage by free radicals and seem to be important in neuroprotection, inflammatory diseases and, presumably, aging. Newly discovered influences on sirtuins and downstream factors indicate that melatonin has a role in mitochondrial biogenesis.
format Artículo
author Srinivasan, Venkataramanujan
Pandi Perumal, Seithikurippu R.
Brown, Gregory M.
Cardinali, Daniel Pedro
Spence, David Warren
Hardeland, Rüdiger
author_facet Srinivasan, Venkataramanujan
Pandi Perumal, Seithikurippu R.
Brown, Gregory M.
Cardinali, Daniel Pedro
Spence, David Warren
Hardeland, Rüdiger
author_sort Srinivasan, Venkataramanujan
title Melatonin : a pleiotropic, orchestrating regulator molecule
title_short Melatonin : a pleiotropic, orchestrating regulator molecule
title_full Melatonin : a pleiotropic, orchestrating regulator molecule
title_fullStr Melatonin : a pleiotropic, orchestrating regulator molecule
title_full_unstemmed Melatonin : a pleiotropic, orchestrating regulator molecule
title_sort melatonin : a pleiotropic, orchestrating regulator molecule
publisher Elsevier
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1653
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AT cardinalidanielpedro melatoninapleiotropicorchestratingregulatormolecule
AT spencedavidwarren melatoninapleiotropicorchestratingregulatormolecule
AT hardelandrudiger melatoninapleiotropicorchestratingregulatormolecule
bdutipo_str Repositorios
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