Melatonin effect on plasma adiponectin, leptin, insulin, glucose, triglycerides and cholesterol in normal and high-fat fed rats

Abstract: Melatonin effect on body weight progression, mean levels and 24‐hour pattern of circulating adiponectin, leptin, insulin, glucose, triglycerides and cholesterol were examined in rats fed a normal or a high‐fat diet. In experiment 1, rats fed a normal diet were divided into two groups, rece...

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Detalles Bibliográficos
Autores principales: Ríos Lugo, María J., Cano Barquilla, Pilar, Jiménez Ortega, Vanesa, Fernández Mateos, María P., Scacchi, Pablo, Cardinali, Daniel Pedro, Esquifino, Ana I.
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: 2019
Materias:
MELATONINA
RITMO CIRCADIANO
INSULINA
LEPTINA
ADIPONECTINA
GRASAS EN LA DIETA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1650
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1650
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic MELATONINA
RITMO CIRCADIANO
INSULINA
LEPTINA
ADIPONECTINA
GRASAS EN LA DIETA
spellingShingle MELATONINA
RITMO CIRCADIANO
INSULINA
LEPTINA
ADIPONECTINA
GRASAS EN LA DIETA
Ríos Lugo, María J.
Cano Barquilla, Pilar
Jiménez Ortega, Vanesa
Fernández Mateos, María P.
Scacchi, Pablo
Cardinali, Daniel Pedro
Esquifino, Ana I.
Melatonin effect on plasma adiponectin, leptin, insulin, glucose, triglycerides and cholesterol in normal and high-fat fed rats
topic_facet MELATONINA
RITMO CIRCADIANO
INSULINA
LEPTINA
ADIPONECTINA
GRASAS EN LA DIETA
description Abstract: Melatonin effect on body weight progression, mean levels and 24‐hour pattern of circulating adiponectin, leptin, insulin, glucose, triglycerides and cholesterol were examined in rats fed a normal or a high‐fat diet. In experiment 1, rats fed a normal diet were divided into two groups, receiving melatonin (25 μg/mL drinking water) or vehicle for 9 weeks. In experiment 2, animals were divided into 3 groups, two fed with a high‐fat diet (35% fat) and melatonin (25 μg/mL) or vehicle in drinking water for 11 weeks, while a third group was given a normal diet (4% fat). At the end of experiments groups of 8 rats were killed at 6 different time intervals throughout a 24 hour period. Melatonin administration for 9 weeks decreased body weight gain from the 3rd week on without affecting food intake. A significant reduction of circulating insulin, glucose and triglyceride mean levels and disrupted daily patterns of plasma adiponectin, leptin and insulin were observed after melatonin. In high‐fat fed rats, melatonin attenuated body weight increase, hyperglycemia and hyperinsulinemia, as well as the increase in mean plasma adiponectin, leptin, triglycerides and cholesterol levels. The high‐fat diet disrupted normal 24 h patterns of circulating adiponectin, insulin and cholesterol, the effects on insulin and cholesterol being counteracted by melatonin. Nocturnal plasma melatonin concentration in control and obese rats receiving melatonin for 11 weeks attained values 21‐24‐fold greater than controls. The results indicate that melatonin counteracts some of the disrupting effects of diet‐induced obesity in rats.
format Artículo
author Ríos Lugo, María J.
Cano Barquilla, Pilar
Jiménez Ortega, Vanesa
Fernández Mateos, María P.
Scacchi, Pablo
Cardinali, Daniel Pedro
Esquifino, Ana I.
author_facet Ríos Lugo, María J.
Cano Barquilla, Pilar
Jiménez Ortega, Vanesa
Fernández Mateos, María P.
Scacchi, Pablo
Cardinali, Daniel Pedro
Esquifino, Ana I.
author_sort Ríos Lugo, María J.
title Melatonin effect on plasma adiponectin, leptin, insulin, glucose, triglycerides and cholesterol in normal and high-fat fed rats
title_short Melatonin effect on plasma adiponectin, leptin, insulin, glucose, triglycerides and cholesterol in normal and high-fat fed rats
title_full Melatonin effect on plasma adiponectin, leptin, insulin, glucose, triglycerides and cholesterol in normal and high-fat fed rats
title_fullStr Melatonin effect on plasma adiponectin, leptin, insulin, glucose, triglycerides and cholesterol in normal and high-fat fed rats
title_full_unstemmed Melatonin effect on plasma adiponectin, leptin, insulin, glucose, triglycerides and cholesterol in normal and high-fat fed rats
title_sort melatonin effect on plasma adiponectin, leptin, insulin, glucose, triglycerides and cholesterol in normal and high-fat fed rats
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1650
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