Orthostatic hypotension in Parkinson's disease

Abstract: Orthostatic hypotension (OH) is a frequent non-motor symptom in Parkinson’s Disease (PD) affecting between 22.9 and 38.4% of patients. OH is related in PD to increased risk of falls and possibly to cognitive dysfunction and increased mortality. These data emphasizes the importance of its p...

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Autores principales: Pérez Lloret, Santiago, Rey, Verónica, Pavy-Le Traon, Anne, Rascol, Olivier
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Future Medicine 2019
Materias:
HIPOTENSION ORTOSTATICA
ENFERMEDAD DE PARKINSON
EPIDEMIOLOGIA
MEDICINA BASADA EN EVIDENCIA
FLUDROCORTISONA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1649
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1649
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic HIPOTENSION ORTOSTATICA
ENFERMEDAD DE PARKINSON
EPIDEMIOLOGIA
MEDICINA BASADA EN EVIDENCIA
FLUDROCORTISONA
spellingShingle HIPOTENSION ORTOSTATICA
ENFERMEDAD DE PARKINSON
EPIDEMIOLOGIA
MEDICINA BASADA EN EVIDENCIA
FLUDROCORTISONA
Pérez Lloret, Santiago
Rey, Verónica
Pavy-Le Traon, Anne
Rascol, Olivier
Orthostatic hypotension in Parkinson's disease
topic_facet HIPOTENSION ORTOSTATICA
ENFERMEDAD DE PARKINSON
EPIDEMIOLOGIA
MEDICINA BASADA EN EVIDENCIA
FLUDROCORTISONA
description Abstract: Orthostatic hypotension (OH) is a frequent non-motor symptom in Parkinson’s Disease (PD) affecting between 22.9 and 38.4% of patients. OH is related in PD to increased risk of falls and possibly to cognitive dysfunction and increased mortality. These data emphasizes the importance of its prompt recognition and treatment. OH is related to pre-ganglionic and post-ganglionic adrenergic denervation, but other factors such as drugs, heat, meals or alcohol intake might also induce or aggravate it. Evidence about the efficacy and safety of pharmacological or non-pharmacological strategies for OH treatment in PD is weak. Non-pharmacological measures include liberal addition of salt to the diet, exercise, compression stocking or physical maneuvers. Severe cases may be treated with midodrine or fludrocortisone. Some results suggest that droxidopa and fipamezole might be effective treatments. We finish this review article by discussing the most important unanswered questions about PD-related OH, which might be the focus of future research
format Artículo
author Pérez Lloret, Santiago
Rey, Verónica
Pavy-Le Traon, Anne
Rascol, Olivier
author_facet Pérez Lloret, Santiago
Rey, Verónica
Pavy-Le Traon, Anne
Rascol, Olivier
author_sort Pérez Lloret, Santiago
title Orthostatic hypotension in Parkinson's disease
title_short Orthostatic hypotension in Parkinson's disease
title_full Orthostatic hypotension in Parkinson's disease
title_fullStr Orthostatic hypotension in Parkinson's disease
title_full_unstemmed Orthostatic hypotension in Parkinson's disease
title_sort orthostatic hypotension in parkinson's disease
publisher Future Medicine
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1649
work_keys_str_mv AT perezlloretsantiago orthostatichypotensioninparkinsonsdisease
AT reyveronica orthostatichypotensioninparkinsonsdisease
AT pavyletraonanne orthostatichypotensioninparkinsonsdisease
AT rascololivier orthostatichypotensioninparkinsonsdisease
bdutipo_str Repositorios
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