Pharmacotherapy of insomnia with ramelteon : safety, efficacy and clinical applications

Abstract: Ramelteon is a tricyclic synthetic analog of melatonin that acts specifically on MT1 and MT2 melatonin receptors. Ramelteon is the first melatonin receptor agonist approved by the Food and Drug Administration (FDA) for the treatment of insomnia characterized by sleep onset difficulties. Ra...

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Autores principales: Pandi Perumal, Seithikurippu R., Spence, David Warren, Verster, Joris C., Srinivasan, Venkataramanujan, Brown, Gregory M., Cardinali, Daniel Pedro, Hardeland, Rüdiger
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Libertas Academica 2019
Materias:
RITMO CIRCADIANO
MELATONINA
RAMELTEON
SUEÑO
INSOMNIO
HIPNOTICOS Y SEDANTES
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1646
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1646
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic RITMO CIRCADIANO
MELATONINA
RAMELTEON
SUEÑO
INSOMNIO
HIPNOTICOS Y SEDANTES
spellingShingle RITMO CIRCADIANO
MELATONINA
RAMELTEON
SUEÑO
INSOMNIO
HIPNOTICOS Y SEDANTES
Pandi Perumal, Seithikurippu R.
Spence, David Warren
Verster, Joris C.
Srinivasan, Venkataramanujan
Brown, Gregory M.
Cardinali, Daniel Pedro
Hardeland, Rüdiger
Pharmacotherapy of insomnia with ramelteon : safety, efficacy and clinical applications
topic_facet RITMO CIRCADIANO
MELATONINA
RAMELTEON
SUEÑO
INSOMNIO
HIPNOTICOS Y SEDANTES
description Abstract: Ramelteon is a tricyclic synthetic analog of melatonin that acts specifically on MT1 and MT2 melatonin receptors. Ramelteon is the first melatonin receptor agonist approved by the Food and Drug Administration (FDA) for the treatment of insomnia characterized by sleep onset difficulties. Ramelteon is both a chronobiotic and a hypnotic that has been shown to promote sleep initiation and maintenance in various preclinical and in clinical trials. The efficacy and safety of ramelteon in patients with chronic insomnia was initially confirmed in short-term placebo-controlled trials. These showed little evidence of next-day residual effects, withdrawal symptoms or rebound insomnia. Other studies indicated that ramelteon lacked abuse potential and had a minimal risk of producing dependence or adverse effects on cognitive or psychomotor performance. A 6-month placebo-controlled international study and a 1-year open-label study in the USA demonstrated that ramelteon was effective and well tolerated. Other potential off-label uses of ramelteon include circadian rhythm sleep disorders such as shift-work and jet lag. At the present time the drug should be cautiously prescribed for short-term treatment only.
format Artículo
author Pandi Perumal, Seithikurippu R.
Spence, David Warren
Verster, Joris C.
Srinivasan, Venkataramanujan
Brown, Gregory M.
Cardinali, Daniel Pedro
Hardeland, Rüdiger
author_facet Pandi Perumal, Seithikurippu R.
Spence, David Warren
Verster, Joris C.
Srinivasan, Venkataramanujan
Brown, Gregory M.
Cardinali, Daniel Pedro
Hardeland, Rüdiger
author_sort Pandi Perumal, Seithikurippu R.
title Pharmacotherapy of insomnia with ramelteon : safety, efficacy and clinical applications
title_short Pharmacotherapy of insomnia with ramelteon : safety, efficacy and clinical applications
title_full Pharmacotherapy of insomnia with ramelteon : safety, efficacy and clinical applications
title_fullStr Pharmacotherapy of insomnia with ramelteon : safety, efficacy and clinical applications
title_full_unstemmed Pharmacotherapy of insomnia with ramelteon : safety, efficacy and clinical applications
title_sort pharmacotherapy of insomnia with ramelteon : safety, efficacy and clinical applications
publisher Libertas Academica
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1646
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