Melatonin and its agonist ramelteon in Alzheimer's disease : possible therapeutic value

Abstract: Alzheimer’s disease (AD) is an age-associated neurodegenerative disease characterized by the progressive loss of cognitive function, loss of memory and insomnia, and abnormal behavioral signs and symptoms. Among the various theories that have been put forth to explain the pathophysiology o...

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Autores principales: Srinivasan, Venkataramanujan, Pandi Perumal, Seithikurippu R., Kaur, Charanjit, Brown, Gregory M., Cardinali, Daniel Pedro
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Hindawi 2019
Materias:
MELATONINA
RAMELTEON
ENFERMEDAD DE ALZHEIMER
AGONISTAS
TERAPIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1645
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1645
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic MELATONINA
RAMELTEON
ENFERMEDAD DE ALZHEIMER
AGONISTAS
TERAPIA
spellingShingle MELATONINA
RAMELTEON
ENFERMEDAD DE ALZHEIMER
AGONISTAS
TERAPIA
Srinivasan, Venkataramanujan
Pandi Perumal, Seithikurippu R.
Kaur, Charanjit
Brown, Gregory M.
Cardinali, Daniel Pedro
Melatonin and its agonist ramelteon in Alzheimer's disease : possible therapeutic value
topic_facet MELATONINA
RAMELTEON
ENFERMEDAD DE ALZHEIMER
AGONISTAS
TERAPIA
description Abstract: Alzheimer’s disease (AD) is an age-associated neurodegenerative disease characterized by the progressive loss of cognitive function, loss of memory and insomnia, and abnormal behavioral signs and symptoms. Among the various theories that have been put forth to explain the pathophysiology of AD, the oxidative stress induced by amyloid β-protein (Aβ) deposition has received great attention. Studies undertaken on postmortem brain samples of AD patients have consistently shown extensive lipid, protein, and DNA oxidation. Presence of abnormal tau protein, mitochondrial dysfunction, and protein hyperphosphorylation all have been demonstrated in neural tissues of AD patients. Moreover, AD patients exhibit severe sleep/wake disturbances and insomnia and these are associated with more rapid cognitive decline and memory impairment. On this basis, the successful management of AD patients requires an ideal drug that besides antagonizing Aβ-induced neurotoxicity could also correct the disturbed sleep-wake rhythm and improve sleep quality. Melatonin is an effective chronobiotic agent and has significant neuroprotective properties preventing Aβ-induced neurotoxic effects in a number of animal experimental models. Since melatonin levels in AD patients are greatly reduced, melatonin replacement has the potential value to be used as a therapeutic agent for treating AD, particularly at the early phases of the disease and especially in those in whom the relevant melatonin receptors are intact. As sleep deprivation has been shown to produce oxidative damage, impaired mitochondrial function, neurodegenerative inflammation, and altered proteosomal processing with abnormal activation of enzymes, treatment of sleep disturbances may be a priority for arresting the progression of AD. In this context the newly introduced melatonin agonist ramelteon can be of much therapeutic value because of its highly selective action on melatonin MT1/MT2 receptors in promoting sleep.
format Artículo
author Srinivasan, Venkataramanujan
Pandi Perumal, Seithikurippu R.
Kaur, Charanjit
Brown, Gregory M.
Cardinali, Daniel Pedro
author_facet Srinivasan, Venkataramanujan
Pandi Perumal, Seithikurippu R.
Kaur, Charanjit
Brown, Gregory M.
Cardinali, Daniel Pedro
author_sort Srinivasan, Venkataramanujan
title Melatonin and its agonist ramelteon in Alzheimer's disease : possible therapeutic value
title_short Melatonin and its agonist ramelteon in Alzheimer's disease : possible therapeutic value
title_full Melatonin and its agonist ramelteon in Alzheimer's disease : possible therapeutic value
title_fullStr Melatonin and its agonist ramelteon in Alzheimer's disease : possible therapeutic value
title_full_unstemmed Melatonin and its agonist ramelteon in Alzheimer's disease : possible therapeutic value
title_sort melatonin and its agonist ramelteon in alzheimer's disease : possible therapeutic value
publisher Hindawi
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1645
work_keys_str_mv AT srinivasanvenkataramanujan melatoninanditsagonistramelteoninalzheimersdiseasepossibletherapeuticvalue
AT pandiperumalseithikurippur melatoninanditsagonistramelteoninalzheimersdiseasepossibletherapeuticvalue
AT kaurcharanjit melatoninanditsagonistramelteoninalzheimersdiseasepossibletherapeuticvalue
AT browngregorym melatoninanditsagonistramelteoninalzheimersdiseasepossibletherapeuticvalue
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