Melatonin and diet-induced metabolic syndrome in rats. Impact on the hypophysial-testicular axis

Abstract: Combinations of fructose- and fat-rich diets in experimental animals can model the human metabolic syndrome (MS). In rats the increase in blood pressure (BP) after diet manipulation is sex-related and highly dependent on testosterone secretion. However, the extent of diet impact on rodent...

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Detalles Bibliográficos
Autores principales: Scacchi Bernasconi, Pablo A., Cardoso, Nancy P., Reynoso, Roxana, Scacchi, Pablo, Cardinali, Daniel Pedro
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: De Gruyter 2019
Materias:
MELATONINA
SINDROME METABOLICO
FRUCTOSA
DIETA
LH
FSH
HIPERTENSION
DISLIPIDEMIAS
TOLERANCIA A LA GLUCOSA
ACIDO URICO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1644
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1644
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic MELATONINA
SINDROME METABOLICO
FRUCTOSA
DIETA
LH
FSH
HIPERTENSION
DISLIPIDEMIAS
TOLERANCIA A LA GLUCOSA
ACIDO URICO
spellingShingle MELATONINA
SINDROME METABOLICO
FRUCTOSA
DIETA
LH
FSH
HIPERTENSION
DISLIPIDEMIAS
TOLERANCIA A LA GLUCOSA
ACIDO URICO
Scacchi Bernasconi, Pablo A.
Cardoso, Nancy P.
Reynoso, Roxana
Scacchi, Pablo
Cardinali, Daniel Pedro
Melatonin and diet-induced metabolic syndrome in rats. Impact on the hypophysial-testicular axis
topic_facet MELATONINA
SINDROME METABOLICO
FRUCTOSA
DIETA
LH
FSH
HIPERTENSION
DISLIPIDEMIAS
TOLERANCIA A LA GLUCOSA
ACIDO URICO
description Abstract: Combinations of fructose- and fat-rich diets in experimental animals can model the human metabolic syndrome (MS). In rats the increase in blood pressure (BP) after diet manipulation is sex-related and highly dependent on testosterone secretion. However, the extent of diet impact on rodent hypophysial-testicular axis remains undefined. In the present study rats drinking a 10% fructose solution or fed a high fat (35%) diet for 10 weeks had higher plasma levels of luteinizing hormone (LH) and lower plasma levels of testosterone, with absence of significant changes in circulating follicle-stimulating hormone (FSH) or in weight of most reproductive organs. Diet manipulation brought about a significant increase in body weight, systolic BP, area under the curve (AUC) of glycemia after an i.p. glucose tolerance test (IPGTT) and plasma lowdensity lipoprotein-cholesterol, cholesterol, triglycerides and uric acid levels. The concomitant administration of melatonin (25 μg/mL of drinking water) normalized the abnormally high LH levels but did not affect the inhibited testosterone secretion found in fructose- or high fat-fed rats. Rather melatonin per se inhibited testosterone secretion. Melatonin significantly blunted the body weight and systolic BP increase, the increase in the AUC of glycemia after an IPGTT and the changes in circulating lipid profile and uric acid found in both MS models. The results are compatible with a primary inhibition of testicular function in the diet-induced MS in rats and with the partial effectiveness of melatonin to counteract the metabolic but not the testicular sequels of rodent MS
format Artículo
author Scacchi Bernasconi, Pablo A.
Cardoso, Nancy P.
Reynoso, Roxana
Scacchi, Pablo
Cardinali, Daniel Pedro
author_facet Scacchi Bernasconi, Pablo A.
Cardoso, Nancy P.
Reynoso, Roxana
Scacchi, Pablo
Cardinali, Daniel Pedro
author_sort Scacchi Bernasconi, Pablo A.
title Melatonin and diet-induced metabolic syndrome in rats. Impact on the hypophysial-testicular axis
title_short Melatonin and diet-induced metabolic syndrome in rats. Impact on the hypophysial-testicular axis
title_full Melatonin and diet-induced metabolic syndrome in rats. Impact on the hypophysial-testicular axis
title_fullStr Melatonin and diet-induced metabolic syndrome in rats. Impact on the hypophysial-testicular axis
title_full_unstemmed Melatonin and diet-induced metabolic syndrome in rats. Impact on the hypophysial-testicular axis
title_sort melatonin and diet-induced metabolic syndrome in rats. impact on the hypophysial-testicular axis
publisher De Gruyter
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1644
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