Melatonin may curtail the metabolic syndrome : studies on initial and fully established fructose-induced metabolic syndrome in rats

Abstract: To examine the effect of melatonin given to rats simultaneously with fructose on initial and fully developed metabolic syndrome, male Wistar rats had free access to chow and 5% or 10% fructose drinking solution for 8 weeks. As compared to controls, systolic blood pressure augmented signifi...

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Autores principales: Cardinali, Daniel Pedro, Scacchi Bernasconi, Pablo A., Reynoso, Roxana, Reyes Toso, Carlos F., Scacchi, Pablo
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Multidisciplinary Digital Publishing Institute 2019
Materias:
SINDROME METABOLICO
MELATONINA
HIPERTENSION
FRUCTOSA
DISLIPIDEMIA
OBESIDAD
TOLERANCIA A LA GLUCOSA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1639
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1639
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic SINDROME METABOLICO
MELATONINA
HIPERTENSION
FRUCTOSA
DISLIPIDEMIA
OBESIDAD
TOLERANCIA A LA GLUCOSA
spellingShingle SINDROME METABOLICO
MELATONINA
HIPERTENSION
FRUCTOSA
DISLIPIDEMIA
OBESIDAD
TOLERANCIA A LA GLUCOSA
Cardinali, Daniel Pedro
Scacchi Bernasconi, Pablo A.
Reynoso, Roxana
Reyes Toso, Carlos F.
Scacchi, Pablo
Melatonin may curtail the metabolic syndrome : studies on initial and fully established fructose-induced metabolic syndrome in rats
topic_facet SINDROME METABOLICO
MELATONINA
HIPERTENSION
FRUCTOSA
DISLIPIDEMIA
OBESIDAD
TOLERANCIA A LA GLUCOSA
description Abstract: To examine the effect of melatonin given to rats simultaneously with fructose on initial and fully developed metabolic syndrome, male Wistar rats had free access to chow and 5% or 10% fructose drinking solution for 8 weeks. As compared to controls, systolic blood pressure augmented significantly under both treatments whereas excessive body weight was seen in rats receiving the 10% fructose only. Rats drinking 5% fructose showed a greater tolerance to a glucose load while rats having access to a 10% fructose drinking solution exhibited the expected impaired glucose tolerance found in the metabolic syndrome. Circulating triglyceride and low density lipoproteins-cholesterol (LDL-c) concentration augmented significantly in rats showing a fully developed metabolic syndrome only, while high blood cholesterol levels were found at both stages examined. Melatonin (25 μg/mL drinking solution) counteracted the changes in body weight and systolic blood pressure found in rats administered with fructose. Melatonin decreased the abnormal hyperglycemia seen after a glucose load in 10% fructose-treated rats but it did not modify the greater tolerance to glucose observed in animals drinking 5% fructose. Melatonin also counteracted the changes in plasma LDL-c, triglyceride and cholesterol levels and decreased plasma uric acid levels. The results underline a possible therapeutical role of melatonin in the metabolic syndrome, both at initial and established phases
format Artículo
author Cardinali, Daniel Pedro
Scacchi Bernasconi, Pablo A.
Reynoso, Roxana
Reyes Toso, Carlos F.
Scacchi, Pablo
author_facet Cardinali, Daniel Pedro
Scacchi Bernasconi, Pablo A.
Reynoso, Roxana
Reyes Toso, Carlos F.
Scacchi, Pablo
author_sort Cardinali, Daniel Pedro
title Melatonin may curtail the metabolic syndrome : studies on initial and fully established fructose-induced metabolic syndrome in rats
title_short Melatonin may curtail the metabolic syndrome : studies on initial and fully established fructose-induced metabolic syndrome in rats
title_full Melatonin may curtail the metabolic syndrome : studies on initial and fully established fructose-induced metabolic syndrome in rats
title_fullStr Melatonin may curtail the metabolic syndrome : studies on initial and fully established fructose-induced metabolic syndrome in rats
title_full_unstemmed Melatonin may curtail the metabolic syndrome : studies on initial and fully established fructose-induced metabolic syndrome in rats
title_sort melatonin may curtail the metabolic syndrome : studies on initial and fully established fructose-induced metabolic syndrome in rats
publisher Multidisciplinary Digital Publishing Institute
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1639
work_keys_str_mv AT cardinalidanielpedro melatoninmaycurtailthemetabolicsyndromestudiesoninitialandfullyestablishedfructoseinducedmetabolicsyndromeinrats
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bdutipo_str Repositorios
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