Melatonin counteracts changes in hypothalamic gene expression of signals regulating feeding behavior in high-fat fed rats
Abstract: Background: Previous studies indicate that the administration of melatonin caused body weight and abdominal visceral fat reductions in rodent models of hyperadiposity. The objective of the present study performed in high-fat fed rats was to evaluate the activity of melatonin on gene expres...
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| Autores principales: | , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés Inglés |
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De Gruyter
2019
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| Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/1638 |
| Aporte de: |
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I33-R139123456789-1638 |
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dspace |
| institution |
Universidad Católica Argentina |
| institution_str |
I-33 |
| repository_str |
R-139 |
| collection |
Repositorio Institucional de la Universidad Católica Argentina (UCA) |
| language |
Inglés Inglés |
| topic |
MELATONINA GRASAS EN LA DIETA ALIMENTACION EXPRESION GENICA NEUROPEPTIDO Y PROOPIOMELANOCORTINA PROLACTINA LEPTINA ADIPONECTINA HIPOTALAMO MEDIO |
| spellingShingle |
MELATONINA GRASAS EN LA DIETA ALIMENTACION EXPRESION GENICA NEUROPEPTIDO Y PROOPIOMELANOCORTINA PROLACTINA LEPTINA ADIPONECTINA HIPOTALAMO MEDIO Jiménez Ortega, Vanesa Ríos Lugo, María J. Cano Barquilla, Pilar Cardinali, Daniel Pedro Esquifino, Ana I. Fernández Mateos, Pilar Spinedi, Eduardo J. Melatonin counteracts changes in hypothalamic gene expression of signals regulating feeding behavior in high-fat fed rats |
| topic_facet |
MELATONINA GRASAS EN LA DIETA ALIMENTACION EXPRESION GENICA NEUROPEPTIDO Y PROOPIOMELANOCORTINA PROLACTINA LEPTINA ADIPONECTINA HIPOTALAMO MEDIO |
| description |
Abstract: Background: Previous studies indicate that the administration of melatonin caused body weight and abdominal visceral fat reductions in rodent models of hyperadiposity. The objective of the present study performed in high-fat fed rats was to evaluate the activity of melatonin on gene expression of some medial basal hypothalamus (MBH) signals involved in feeding behavior regulation, including neuropeptide Y (NPY), proopiomelanocortin (POMC), prolactin-releasing peptide (PrRP), leptin- and insulinreceptors (R) and insulin-R substrate (IRS)-1 and -2. Blood levels of leptin and adiponectin were also measured. Methods: Adult Wistar male rats were divided into four groups (n= 16/group): (i) control diet (3 % fat); (ii) high-fat (35 %) diet; (iii) high-fat diet + melatonin; (iv) control diet + melatonin. Rats had free access to high-fat or control chow and one of the following drinking solutions: (a) tap water; (b) 25 μg/mL of melatonin. Results: After 10 weeks, the high-fat fed rats showed augmented MBH mRNA levels of NPY, leptin-R, PrRP, insulin-R, IRS-1 and IRS-2. The concomitant administration of melatonin counteracted this increase. Feeding of rats with a high-fat diet augmented expression of MBH POMC gene through an effect insensitive to melatonin treatment. The augmented levels of circulating leptin and adiponectin seen in high-fat fed rats were counteracted by melatonin as was the augmented body weight: melatonin significantly attenuated body weight increase in high-fat fed rats without affecting chow or water consumption. Melatonin augmented plasma leptin and adiponectin in control rats. Conclusions: The results indicate that an effect on gene expression of feeding behavior signals at the CNS may complement a peripheral rise of the energy expenditure produced by melatonin to decrease body weight in high-fat fed rats |
| format |
Artículo |
| author |
Jiménez Ortega, Vanesa Ríos Lugo, María J. Cano Barquilla, Pilar Cardinali, Daniel Pedro Esquifino, Ana I. Fernández Mateos, Pilar Spinedi, Eduardo J. |
| author_facet |
Jiménez Ortega, Vanesa Ríos Lugo, María J. Cano Barquilla, Pilar Cardinali, Daniel Pedro Esquifino, Ana I. Fernández Mateos, Pilar Spinedi, Eduardo J. |
| author_sort |
Jiménez Ortega, Vanesa |
| title |
Melatonin counteracts changes in hypothalamic gene expression of signals regulating feeding behavior in high-fat fed rats |
| title_short |
Melatonin counteracts changes in hypothalamic gene expression of signals regulating feeding behavior in high-fat fed rats |
| title_full |
Melatonin counteracts changes in hypothalamic gene expression of signals regulating feeding behavior in high-fat fed rats |
| title_fullStr |
Melatonin counteracts changes in hypothalamic gene expression of signals regulating feeding behavior in high-fat fed rats |
| title_full_unstemmed |
Melatonin counteracts changes in hypothalamic gene expression of signals regulating feeding behavior in high-fat fed rats |
| title_sort |
melatonin counteracts changes in hypothalamic gene expression of signals regulating feeding behavior in high-fat fed rats |
| publisher |
De Gruyter |
| publishDate |
2019 |
| url |
https://repositorio.uca.edu.ar/handle/123456789/1638 |
| work_keys_str_mv |
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Repositorios |
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1764820525762215938 |