Melatonin and mitochondrial dysfunction in the central nervous system

Abstract: Cell death and survival are critical events for neurodegeneration, mitochondria being increasingly seen as important determinants of both. Mitochondrial dysfunction is considered a major causative factor in Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD). I...

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Autores principales: Cardinali, Daniel Pedro, Pagano, Eleonora S., Scacchi Bernasconi, Pablo A., Reynoso, Roxana, Scacchi, Pablo
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Elsevier 2019
Materias:
MELATONINA
MITOCONDRIAS
SISTEMA NERVIOSO CENTRAL
RADICALES LIBRES
ENVEJECIMIENTO
STRESS
ENFERMEDAD DE ALZHEIMER
ENFERMEDAD DE HUNTINGTON
ENFERMEDAD DE PARKINSON
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1632
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1632
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic MELATONINA
MITOCONDRIAS
SISTEMA NERVIOSO CENTRAL
RADICALES LIBRES
ENVEJECIMIENTO
STRESS
ENFERMEDAD DE ALZHEIMER
ENFERMEDAD DE HUNTINGTON
ENFERMEDAD DE PARKINSON
spellingShingle MELATONINA
MITOCONDRIAS
SISTEMA NERVIOSO CENTRAL
RADICALES LIBRES
ENVEJECIMIENTO
STRESS
ENFERMEDAD DE ALZHEIMER
ENFERMEDAD DE HUNTINGTON
ENFERMEDAD DE PARKINSON
Cardinali, Daniel Pedro
Pagano, Eleonora S.
Scacchi Bernasconi, Pablo A.
Reynoso, Roxana
Scacchi, Pablo
Melatonin and mitochondrial dysfunction in the central nervous system
topic_facet MELATONINA
MITOCONDRIAS
SISTEMA NERVIOSO CENTRAL
RADICALES LIBRES
ENVEJECIMIENTO
STRESS
ENFERMEDAD DE ALZHEIMER
ENFERMEDAD DE HUNTINGTON
ENFERMEDAD DE PARKINSON
description Abstract: Cell death and survival are critical events for neurodegeneration, mitochondria being increasingly seen as important determinants of both. Mitochondrial dysfunction is considered a major causative factor in Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD). Increased free radical generation, enhanced mitochondrial inducible nitric oxide (NO) synthase activity and NO production, and disrupted electron transport system and mitochondrial permeability transition, have all been involved in impaired mitochondrial function. Melatonin, the major secretory product of the pineal gland, is an antioxidant and an effective protector of mitochondrial bioenergetic function. Both in vitro and in vivo, melatonin was effective to prevent oxidative stress/nitrosative stress-induced mitochondrial dysfunction seen in experimental models of AD, PD and HD. These effects are seen at doses 2-3 orders of magnitude higher than those required to affect sleep and circadian rhythms, both conspicuous targets of melatonin action. Melatonin is selectively taken up by mitochondria, a function not shared by other antioxidants. A limited number of clinical studies indicate that melatonin can improve sleep and circadian rhythm disruption in PD and AD patients. More recently, attention has been focused on the development of potent melatonin analogs with prolonged effects which were employed in clinical trials in sleep-disturbed or depressed patients in doses considerably higher than those employed for melatonin. In view that the relative potencies of the analogs are higher than that of the natural compound, clinical trials employing melatonin in the range of 50-100 mg/day are needed to assess its therapeutic validity in neurodegenerative disorders.
format Artículo
author Cardinali, Daniel Pedro
Pagano, Eleonora S.
Scacchi Bernasconi, Pablo A.
Reynoso, Roxana
Scacchi, Pablo
author_facet Cardinali, Daniel Pedro
Pagano, Eleonora S.
Scacchi Bernasconi, Pablo A.
Reynoso, Roxana
Scacchi, Pablo
author_sort Cardinali, Daniel Pedro
title Melatonin and mitochondrial dysfunction in the central nervous system
title_short Melatonin and mitochondrial dysfunction in the central nervous system
title_full Melatonin and mitochondrial dysfunction in the central nervous system
title_fullStr Melatonin and mitochondrial dysfunction in the central nervous system
title_full_unstemmed Melatonin and mitochondrial dysfunction in the central nervous system
title_sort melatonin and mitochondrial dysfunction in the central nervous system
publisher Elsevier
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1632
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AT paganoeleonoras melatoninandmitochondrialdysfunctioninthecentralnervoussystem
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AT reynosoroxana melatoninandmitochondrialdysfunctioninthecentralnervoussystem
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bdutipo_str Repositorios
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