Agomelatine : its role in the management of major depressive disorder
Abstract: Circadian rhythm abnormalities, as shown by sleep/wake cycle disturbances, constitute one the most prevalent signs of depressive illness; advances or delays in the circadian phase are documented in patients with major depressive disorder (MDD), bipolar disorder, and seasonal affective diso...
Guardado en:
| Autores principales: | , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés Inglés |
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Libertas Academica
2019
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| Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/1630 |
| Aporte de: |
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I33-R139123456789-1630 |
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dspace |
| institution |
Universidad Católica Argentina |
| institution_str |
I-33 |
| repository_str |
R-139 |
| collection |
Repositorio Institucional de la Universidad Católica Argentina (UCA) |
| language |
Inglés Inglés |
| topic |
TRASTORNOS DE LA CONDUCTA DEPRESION AGOMELATINA RECEPTORES DE MELATONINA ANTIDEPRESIVOS ANSIOLITICOS RECEPTORES RECEPTORES DE SEROTONINA |
| spellingShingle |
TRASTORNOS DE LA CONDUCTA DEPRESION AGOMELATINA RECEPTORES DE MELATONINA ANTIDEPRESIVOS ANSIOLITICOS RECEPTORES RECEPTORES DE SEROTONINA Cardinali, Daniel Pedro Vidal, María Florencia Vigo, Daniel Eduardo Agomelatine : its role in the management of major depressive disorder |
| topic_facet |
TRASTORNOS DE LA CONDUCTA DEPRESION AGOMELATINA RECEPTORES DE MELATONINA ANTIDEPRESIVOS ANSIOLITICOS RECEPTORES RECEPTORES DE SEROTONINA |
| description |
Abstract: Circadian rhythm abnormalities, as shown by sleep/wake cycle disturbances, constitute one the most prevalent signs of depressive illness; advances or delays in the circadian phase are documented in patients with major depressive disorder (MDD), bipolar disorder, and seasonal affective disorder (SAD). The disturbances in the amplitude and phase of rhythm in melatonin secretion that occur in patients with depression resemble those seen in chronobiological disorders, thus suggesting a link between disturbed melatonin secretion and depressed mood. Based on this, agomelatine, the first MT1/MT2 melatonergic agonist displaying also 5-HT2C serotonergic antagonism, has been introduced as an antidepressant. Agomelatine has been shown to be effective in several animal models of depression and anxiety and it has beneficial effects in patients with MDD, bipolar disorder, or SAD. Among agomelatine’s characteristics are a rapid onset of action and a pronounced effectiveness for correcting circadian rhythm abnormalities and improving the sleep/wake cycle. Agomelatine also improves the 3 functional dimensions of depression—emotional, cognitive, and social—thus aiding in the full recovery of patients to a normal life |
| format |
Artículo |
| author |
Cardinali, Daniel Pedro Vidal, María Florencia Vigo, Daniel Eduardo |
| author_facet |
Cardinali, Daniel Pedro Vidal, María Florencia Vigo, Daniel Eduardo |
| author_sort |
Cardinali, Daniel Pedro |
| title |
Agomelatine : its role in the management of major depressive disorder |
| title_short |
Agomelatine : its role in the management of major depressive disorder |
| title_full |
Agomelatine : its role in the management of major depressive disorder |
| title_fullStr |
Agomelatine : its role in the management of major depressive disorder |
| title_full_unstemmed |
Agomelatine : its role in the management of major depressive disorder |
| title_sort |
agomelatine : its role in the management of major depressive disorder |
| publisher |
Libertas Academica |
| publishDate |
2019 |
| url |
https://repositorio.uca.edu.ar/handle/123456789/1630 |
| work_keys_str_mv |
AT cardinalidanielpedro agomelatineitsroleinthemanagementofmajordepressivedisorder AT vidalmariaflorencia agomelatineitsroleinthemanagementofmajordepressivedisorder AT vigodanieleduardo agomelatineitsroleinthemanagementofmajordepressivedisorder |
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Repositorios |
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1764820525754875906 |