Clinical aspects of melatonin intervention in Alzheimer's disease progression

Abstract: Melatonin secretion decreases in Alzheimer´s disease (AD) and this decrease has been postulated as responsible for the circadian disorganization, decrease in sleep efficiency and impaired cognitive function seen in those patients. Half of severely ill AD patients develop chronobiological d...

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Autores principales: Cardinali, Daniel Pedro, Furio, Analía M., Brusco, Luis I.
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Bentham Science Publishers 2019
Materias:
MELATONINA
ENFERMEDAD DE ALZHEIMER
ENSAYO CLINICO
RITMO CIRCADIANO
PRUEBAS NEUROPSICOLOGICAS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1625
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1625
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic MELATONINA
ENFERMEDAD DE ALZHEIMER
ENSAYO CLINICO
RITMO CIRCADIANO
PRUEBAS NEUROPSICOLOGICAS
spellingShingle MELATONINA
ENFERMEDAD DE ALZHEIMER
ENSAYO CLINICO
RITMO CIRCADIANO
PRUEBAS NEUROPSICOLOGICAS
Cardinali, Daniel Pedro
Furio, Analía M.
Brusco, Luis I.
Clinical aspects of melatonin intervention in Alzheimer's disease progression
topic_facet MELATONINA
ENFERMEDAD DE ALZHEIMER
ENSAYO CLINICO
RITMO CIRCADIANO
PRUEBAS NEUROPSICOLOGICAS
description Abstract: Melatonin secretion decreases in Alzheimer´s disease (AD) and this decrease has been postulated as responsible for the circadian disorganization, decrease in sleep efficiency and impaired cognitive function seen in those patients. Half of severely ill AD patients develop chronobiological day‐night rhythm disturbances like an agitated behavior during the evening hours (so‐called “sundowning”). Melatonin replacement has been shown effective to treat sundowning and other sleep wake disorders in AD patients. The antioxidant, mitochondrial and antiamyloidogenic effects of melatonin indicate its potentiality to interfere with the onset of the disease. This is of particularly importance in mild cognitive impairment (MCI), an etiologically heterogeneous syndrome that precedes dementia. The aim of this manuscript was to assess published evidence of the efficacy of melatonin to treat AD and MCI patients. PubMed was searched using Entrez for articles including clinical trials and published up to 15 January 2010. Search terms were “Alzheimer” and “melatonin”. Full publications were obtained and references were checked for additional material where appropriate. Only clinical studies with empirical treatment data were reviewed. The analysis of published evidence made it possible to postulate melatonin as a useful ad‐on therapeutic tool in MCI. In the case of AD, larger randomized controlled trials are necessary to yield evidence of effectiveness (i.e. clinical and subjective relevance) before melatonin´s use can be advocated.
format Artículo
author Cardinali, Daniel Pedro
Furio, Analía M.
Brusco, Luis I.
author_facet Cardinali, Daniel Pedro
Furio, Analía M.
Brusco, Luis I.
author_sort Cardinali, Daniel Pedro
title Clinical aspects of melatonin intervention in Alzheimer's disease progression
title_short Clinical aspects of melatonin intervention in Alzheimer's disease progression
title_full Clinical aspects of melatonin intervention in Alzheimer's disease progression
title_fullStr Clinical aspects of melatonin intervention in Alzheimer's disease progression
title_full_unstemmed Clinical aspects of melatonin intervention in Alzheimer's disease progression
title_sort clinical aspects of melatonin intervention in alzheimer's disease progression
publisher Bentham Science Publishers
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1625
work_keys_str_mv AT cardinalidanielpedro clinicalaspectsofmelatonininterventioninalzheimersdiseaseprogression
AT furioanaliam clinicalaspectsofmelatonininterventioninalzheimersdiseaseprogression
AT bruscoluisi clinicalaspectsofmelatonininterventioninalzheimersdiseaseprogression
bdutipo_str Repositorios
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