Jet lag, circadian rhythm sleep disturbances and depression : the role of melatonin and its analogs

Abstract: Travelling through several time zones results in a constellation of symptoms known as jet lag. These include reduced alertness, daytime fatigue, loss of appetite, reduced cognitive skills, and disruptions to sleep/wakefulness and other circadian rhythms. In susceptible air travel passenger...

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Autores principales: Srinivasan, Venkataramanujan, Singh, Jarnail, Pandi Perumal, Seithikurippu R., Spence, David Warren, Brown, Gregory M., Cardinali, Daniel Pedro
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Springer 2019
Materias:
RITMO CIRCADIANO
DEPRESION
MELATONINA
INSOMNIO
FATIGA
TRASTORNOS DEL SUEÑO
RAMELTEON
TASIMELTEON
TRASTONOS CRONOBIOLOGICOS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1621
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1621
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic RITMO CIRCADIANO
DEPRESION
MELATONINA
INSOMNIO
FATIGA
TRASTORNOS DEL SUEÑO
RAMELTEON
TASIMELTEON
TRASTONOS CRONOBIOLOGICOS
spellingShingle RITMO CIRCADIANO
DEPRESION
MELATONINA
INSOMNIO
FATIGA
TRASTORNOS DEL SUEÑO
RAMELTEON
TASIMELTEON
TRASTONOS CRONOBIOLOGICOS
Srinivasan, Venkataramanujan
Singh, Jarnail
Pandi Perumal, Seithikurippu R.
Spence, David Warren
Brown, Gregory M.
Cardinali, Daniel Pedro
Jet lag, circadian rhythm sleep disturbances and depression : the role of melatonin and its analogs
topic_facet RITMO CIRCADIANO
DEPRESION
MELATONINA
INSOMNIO
FATIGA
TRASTORNOS DEL SUEÑO
RAMELTEON
TASIMELTEON
TRASTONOS CRONOBIOLOGICOS
description Abstract: Travelling through several time zones results in a constellation of symptoms known as jet lag. These include reduced alertness, daytime fatigue, loss of appetite, reduced cognitive skills, and disruptions to sleep/wakefulness and other circadian rhythms. In susceptible air travel passengers, jet lag may exacerbate affective illness ans result in psychiatric morbidity. It is suggested that dysregulation of circadian rhythms and melatonin secretion represents the common underlying factor in jet lag and other circadian disorders. Hence the effective management of jet lag requires timely application of the well known chronobiotic melatonin. Recent studies have emphasized the importance of strategically timed administrations of melatonin and appropriate limited exposure to environmental schedules. However, with the introduction of the melatonergic agonists such as ramelteon and tasimelteon, which have both a strong affinity for MT1 and MT2 melatonin receptors and a longer half life, a new therapeutic option now exists for treating the sleep disturbances associated with jet lag. The melatonin analogs are unique inasmuch as they can also enhance daytime alertness. Since jet lag exacerbates affective disorders in susceptible air‐travel passengers, and can thus produce psychiatric morbidity, there is a need for an effective antidepressant with chronobiotic properties. In this regard the recently introduced melatonergic antidepressant agomelatine, which has successfully established its supremacy over other antidepressants in having chronobiotic effects, represents a good choice for treating depressive symptoms that are associated with jet lag.
format Artículo
author Srinivasan, Venkataramanujan
Singh, Jarnail
Pandi Perumal, Seithikurippu R.
Spence, David Warren
Brown, Gregory M.
Cardinali, Daniel Pedro
author_facet Srinivasan, Venkataramanujan
Singh, Jarnail
Pandi Perumal, Seithikurippu R.
Spence, David Warren
Brown, Gregory M.
Cardinali, Daniel Pedro
author_sort Srinivasan, Venkataramanujan
title Jet lag, circadian rhythm sleep disturbances and depression : the role of melatonin and its analogs
title_short Jet lag, circadian rhythm sleep disturbances and depression : the role of melatonin and its analogs
title_full Jet lag, circadian rhythm sleep disturbances and depression : the role of melatonin and its analogs
title_fullStr Jet lag, circadian rhythm sleep disturbances and depression : the role of melatonin and its analogs
title_full_unstemmed Jet lag, circadian rhythm sleep disturbances and depression : the role of melatonin and its analogs
title_sort jet lag, circadian rhythm sleep disturbances and depression : the role of melatonin and its analogs
publisher Springer
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1621
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