Disrupted chronobiology of sleep and cytoprotection in obesity : possible therapeutic value of melatonin

Abstract: From a physiological perspective the sleep-wake cycle can be envisioned as a sequence of three physiological states (wakefulness, non-rapid eye movement, NREM, sleep and REM sleep) which are defined by a particular neuroendocrine-immune profile regulating the metabolic balance, body weight...

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Detalles Bibliográficos
Autores principales: Cardinali, Daniel Pedro, Pagano, Eleonora Samanta, Scacchi Bernasconi, Pablo A., Reynoso, Roxana, Scacchi, Pablo
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Maghira and Maas Publications 2019
Materias:
SUEÑO
DIABETES
OBESIDAD
RITMO CIRCADIANO
RADICALES LIBRES
MELATONINA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1615
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1615
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic SUEÑO
DIABETES
OBESIDAD
RITMO CIRCADIANO
RADICALES LIBRES
MELATONINA
spellingShingle SUEÑO
DIABETES
OBESIDAD
RITMO CIRCADIANO
RADICALES LIBRES
MELATONINA
Cardinali, Daniel Pedro
Pagano, Eleonora Samanta
Scacchi Bernasconi, Pablo A.
Reynoso, Roxana
Scacchi, Pablo
Disrupted chronobiology of sleep and cytoprotection in obesity : possible therapeutic value of melatonin
topic_facet SUEÑO
DIABETES
OBESIDAD
RITMO CIRCADIANO
RADICALES LIBRES
MELATONINA
description Abstract: From a physiological perspective the sleep-wake cycle can be envisioned as a sequence of three physiological states (wakefulness, non-rapid eye movement, NREM, sleep and REM sleep) which are defined by a particular neuroendocrine-immune profile regulating the metabolic balance, body weight and inflammatory responses. Sleep deprivation and circadian disruption in contemporary “24/7 Society” lead to the predominance of pro-orexic and proinflammatory mechanisms that contribute to a pandemic metabolic syndrome (MS) including obesity, diabetes and atherosclerotic disease. Thus, a successful management of MS may require a drug that besides antagonizing the trigger factors of MS could also correct a disturbed sleep-wake rhythm. This review deals with the analysis of the therapeutic validity of melatonin in MS. Melatonin is an effective chronobiotic agent changing the phase and amplitude of the sleep/wake rhythm and having cytoprotective and immunomodulatory properties useful to prevent a number of MS sequels. Several studies support that melatonin can prevent hyperadiposity in animal models of obesity. Melatonin at a low dose (2‐5 mg/day) has been used for improving sleep in patients with insomnia and circadian rhythm sleep disorders. More recently, attention has been focused on the development of potent melatonin analogs with prolonged effects (ramelteon, agomelatine, tasimelteon, TK 301). In clinical trials these analogs were employed in doses considerably higher than those usually employed for melatonin. In view that the relative potencies of the analogs are higher than that of the natural compound, clinical trials employing melatonin doses in the range of 50-100 mg/day are needed to assess its therapeutic value in MS.
format Artículo
author Cardinali, Daniel Pedro
Pagano, Eleonora Samanta
Scacchi Bernasconi, Pablo A.
Reynoso, Roxana
Scacchi, Pablo
author_facet Cardinali, Daniel Pedro
Pagano, Eleonora Samanta
Scacchi Bernasconi, Pablo A.
Reynoso, Roxana
Scacchi, Pablo
author_sort Cardinali, Daniel Pedro
title Disrupted chronobiology of sleep and cytoprotection in obesity : possible therapeutic value of melatonin
title_short Disrupted chronobiology of sleep and cytoprotection in obesity : possible therapeutic value of melatonin
title_full Disrupted chronobiology of sleep and cytoprotection in obesity : possible therapeutic value of melatonin
title_fullStr Disrupted chronobiology of sleep and cytoprotection in obesity : possible therapeutic value of melatonin
title_full_unstemmed Disrupted chronobiology of sleep and cytoprotection in obesity : possible therapeutic value of melatonin
title_sort disrupted chronobiology of sleep and cytoprotection in obesity : possible therapeutic value of melatonin
publisher Maghira and Maas Publications
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1615
work_keys_str_mv AT cardinalidanielpedro disruptedchronobiologyofsleepandcytoprotectioninobesitypossibletherapeuticvalueofmelatonin
AT paganoeleonorasamanta disruptedchronobiologyofsleepandcytoprotectioninobesitypossibletherapeuticvalueofmelatonin
AT scacchibernasconipabloa disruptedchronobiologyofsleepandcytoprotectioninobesitypossibletherapeuticvalueofmelatonin
AT reynosoroxana disruptedchronobiologyofsleepandcytoprotectioninobesitypossibletherapeuticvalueofmelatonin
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bdutipo_str Repositorios
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