Melatonin in septic shock : some recent concepts

Abstract: Melatonin is a versatile molecule, synthesized not only in the pineal gland, but also in many other organs. Melatonin plays an important physiological role in sleep and circadian rhythm regulation, immunoregulation, antioxidant and mitochondrial-protective functions, reproductive control a...

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Detalles Bibliográficos
Autores principales: Srinivasan, Venkataramanujan, Pandi Perumal, Seithikurippu R., Cardinali, Daniel Pedro, Spence, David Warren, Kato, Hisanori
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Elsevier 2019
Materias:
MELATONINA
ANTIOXIDANTES
OXIDO NITRICO
CITOCINAS
CHOQUE SEPTICO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1611
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1611
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic MELATONINA
ANTIOXIDANTES
OXIDO NITRICO
CITOCINAS
CHOQUE SEPTICO
spellingShingle MELATONINA
ANTIOXIDANTES
OXIDO NITRICO
CITOCINAS
CHOQUE SEPTICO
Srinivasan, Venkataramanujan
Pandi Perumal, Seithikurippu R.
Cardinali, Daniel Pedro
Spence, David Warren
Kato, Hisanori
Melatonin in septic shock : some recent concepts
topic_facet MELATONINA
ANTIOXIDANTES
OXIDO NITRICO
CITOCINAS
CHOQUE SEPTICO
description Abstract: Melatonin is a versatile molecule, synthesized not only in the pineal gland, but also in many other organs. Melatonin plays an important physiological role in sleep and circadian rhythm regulation, immunoregulation, antioxidant and mitochondrial-protective functions, reproductive control and regulation of mood. Melatonin has also been reported as effective in combating various bacterial and viral infections. Melatonin is an effective anti-inflammatory agent in various animal models of inflammation and sepsis and its anti-inflammatory action has been attributed to inhibition of nitric oxide synthase with consequent reduction of peroxynitrite formation, to the stimulation of various antioxidant enzymes thus contributing to enhance the antioxidant defense and to protective effects on mitochondrial function and in preventing apoptosis. In a number of animal models of septic shock, as well as in patients with septic disease, melatonin reportedly exerts beneficial effects to arrest cellular damage and multiorgan failure. The significance of these actions in septic shock and its potential usefulness in the treatment of multiorgan failure are discussed.
format Artículo
author Srinivasan, Venkataramanujan
Pandi Perumal, Seithikurippu R.
Cardinali, Daniel Pedro
Spence, David Warren
Kato, Hisanori
author_facet Srinivasan, Venkataramanujan
Pandi Perumal, Seithikurippu R.
Cardinali, Daniel Pedro
Spence, David Warren
Kato, Hisanori
author_sort Srinivasan, Venkataramanujan
title Melatonin in septic shock : some recent concepts
title_short Melatonin in septic shock : some recent concepts
title_full Melatonin in septic shock : some recent concepts
title_fullStr Melatonin in septic shock : some recent concepts
title_full_unstemmed Melatonin in septic shock : some recent concepts
title_sort melatonin in septic shock : some recent concepts
publisher Elsevier
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1611
work_keys_str_mv AT srinivasanvenkataramanujan melatonininsepticshocksomerecentconcepts
AT pandiperumalseithikurippur melatonininsepticshocksomerecentconcepts
AT cardinalidanielpedro melatonininsepticshocksomerecentconcepts
AT spencedavidwarren melatonininsepticshocksomerecentconcepts
AT katohisanori melatonininsepticshocksomerecentconcepts
bdutipo_str Repositorios
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