Therapeutic application of melatonin in mild cognitive impairment

Abstract: Mild cognitive impairment (MCI) is an etiologically heterogeneous syndrome defined by cognitive impairment in advance of dementia. We previously reported in a retrospective analysis that daily 3 - 9 mg of a fast-release melatonin preparation given p. o. at bedtime for up to 3 years signifi...

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Autores principales: Cardinali, Daniel Pedro, Vigo, Daniel Eduardo, Olivar, Natividad, Vidal, María Florencia, Furio, Analía M., Brusco, Luis I.
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: e-Century Publishing 2019
Materias:
ENFERMEDAD DE ALZHEIMER
MELATONINA
BENZODIAZEPINAS
TEST NEUROPSICOLOGICOS
DETERIORO COGNITIVO LEVE
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1608
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1608
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic ENFERMEDAD DE ALZHEIMER
MELATONINA
BENZODIAZEPINAS
TEST NEUROPSICOLOGICOS
DETERIORO COGNITIVO LEVE
spellingShingle ENFERMEDAD DE ALZHEIMER
MELATONINA
BENZODIAZEPINAS
TEST NEUROPSICOLOGICOS
DETERIORO COGNITIVO LEVE
Cardinali, Daniel Pedro
Vigo, Daniel Eduardo
Olivar, Natividad
Vidal, María Florencia
Furio, Analía M.
Brusco, Luis I.
Therapeutic application of melatonin in mild cognitive impairment
topic_facet ENFERMEDAD DE ALZHEIMER
MELATONINA
BENZODIAZEPINAS
TEST NEUROPSICOLOGICOS
DETERIORO COGNITIVO LEVE
description Abstract: Mild cognitive impairment (MCI) is an etiologically heterogeneous syndrome defined by cognitive impairment in advance of dementia. We previously reported in a retrospective analysis that daily 3 - 9 mg of a fast-release melatonin preparation given p. o. at bedtime for up to 3 years significantly improved cognitive and emotional performance and daily sleep/wake cycle in MCI patients. In a follow up of that study we now report data from another series of 96 MCI outpatients, 61 of who had received daily 3 - 24 mg of a fast-release melatonin preparation p. o. at bedtime for 15 to 60 months. Melatonin was given in addition to the standard medication prescribed by the attending psychiatrist. Patients treated with melatonin exhibited significantly better performance in Mini–Mental State Examination and the cognitive subscale of the Alzheimer’s disease Assessment Scale. After application of a neuropsychological battery comprising a Mattis´ test, Digit-symbol test, Trail A and B tasks and the Rey´s verbal test, better performance was found in melatonin-treated patients for every parameter tested. Abnormally high Beck Depression Inventory scores decreased in melatonin-treated patients, concomitantly with the improvement in the quality of sleep and wakefulness. The comparison of the medication profile in both groups of MCI patients indicated that 9.8% in the melatonin group received benzodiazepines vs. 62.8% in the non-melatonin group. The results further support that melatonin can be a useful add-on drug for treating MCI in a clinic environment
format Artículo
author Cardinali, Daniel Pedro
Vigo, Daniel Eduardo
Olivar, Natividad
Vidal, María Florencia
Furio, Analía M.
Brusco, Luis I.
author_facet Cardinali, Daniel Pedro
Vigo, Daniel Eduardo
Olivar, Natividad
Vidal, María Florencia
Furio, Analía M.
Brusco, Luis I.
author_sort Cardinali, Daniel Pedro
title Therapeutic application of melatonin in mild cognitive impairment
title_short Therapeutic application of melatonin in mild cognitive impairment
title_full Therapeutic application of melatonin in mild cognitive impairment
title_fullStr Therapeutic application of melatonin in mild cognitive impairment
title_full_unstemmed Therapeutic application of melatonin in mild cognitive impairment
title_sort therapeutic application of melatonin in mild cognitive impairment
publisher e-Century Publishing
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1608
work_keys_str_mv AT cardinalidanielpedro therapeuticapplicationofmelatonininmildcognitiveimpairment
AT vigodanieleduardo therapeuticapplicationofmelatonininmildcognitiveimpairment
AT olivarnatividad therapeuticapplicationofmelatonininmildcognitiveimpairment
AT vidalmariaflorencia therapeuticapplicationofmelatonininmildcognitiveimpairment
AT furioanaliam therapeuticapplicationofmelatonininmildcognitiveimpairment
AT bruscoluisi therapeuticapplicationofmelatonininmildcognitiveimpairment
bdutipo_str Repositorios
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