Alterations in metabolism and diurnal rhythms following bilateral surgical removal of the superior cervical ganglia in rats

Abstract: Mammalian circadian rhythms are controlled by a master pacemaker located in the suprachiasmatic nuclei (SCN), which is synchronized to the environment by photic and nonphotic stimuli. One of the main functions of the SCN is to regulate peripheral oscillators to set temporal variations in t...

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Detalles Bibliográficos
Autores principales: Mul Fedele, Malena L., Galiana, María D., Golombek, Diego A., Muñoz, Estela M., Plano, Santiago Andrés
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Frontiers Media 2019
Materias:
MELATONINA
RITMO CIRCADIANO
METABOLISMO
HOMEOSTASIS
FISIOLOGIA
ENDOCRINOLOGIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1466
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1466
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic MELATONINA
RITMO CIRCADIANO
METABOLISMO
HOMEOSTASIS
FISIOLOGIA
ENDOCRINOLOGIA
spellingShingle MELATONINA
RITMO CIRCADIANO
METABOLISMO
HOMEOSTASIS
FISIOLOGIA
ENDOCRINOLOGIA
Mul Fedele, Malena L.
Galiana, María D.
Golombek, Diego A.
Muñoz, Estela M.
Plano, Santiago Andrés
Alterations in metabolism and diurnal rhythms following bilateral surgical removal of the superior cervical ganglia in rats
topic_facet MELATONINA
RITMO CIRCADIANO
METABOLISMO
HOMEOSTASIS
FISIOLOGIA
ENDOCRINOLOGIA
description Abstract: Mammalian circadian rhythms are controlled by a master pacemaker located in the suprachiasmatic nuclei (SCN), which is synchronized to the environment by photic and nonphotic stimuli. One of the main functions of the SCN is to regulate peripheral oscillators to set temporal variations in the homeostatic control of physiology and metabolism. In this sense, the SCN coordinate the activity/rest and feeding/fasting rhythms setting the timing of food intake, energy expenditure, thermogenesis, and active and basal metabolism. One of the major time cues to the periphery is the nocturnal melatonin, which is synthesized and secreted by the pineal gland. Under SCN control, arylalkylamine N-acetyltransferase (AA-NAT)—the main enzyme regulating melatonin synthesis in vertebrates—is activated at night by sympathetic innervation that includes the superior cervical ganglia (SCG). Bilateral surgical removal of the superior cervical ganglia (SCGx) is considered a reliable procedure to completely prevent the nocturnal AA-NAT activation, irreversibly suppressing melatonin rhythmicity. In the present work, we studied the effects of SCGx on rat metabolic parameters and diurnal rhythms of feeding and locomotor activity. We found a significant difference between SCGx and sham-operated rats in metabolic variables such as an increased body weight/food intake ratio, increased adipose tissue, and decreased glycemia with a normal glucose tolerance. An analysis of locomotor activity and feeding rhythms showed an increased daytime (lights on) activity (including food consumption) in the SCGx group. These alterations suggest that superior cervical ganglia-related feedback mechanisms play a role in SCN-periphery phase coordination and that SCGx is a valid model without brain-invasive surgery to explore how sympathetic innervation affects daily (24 h) patterns of activity, food consumption and, ultimately, its role in metabolism homeostasis.
format Artículo
author Mul Fedele, Malena L.
Galiana, María D.
Golombek, Diego A.
Muñoz, Estela M.
Plano, Santiago Andrés
author_facet Mul Fedele, Malena L.
Galiana, María D.
Golombek, Diego A.
Muñoz, Estela M.
Plano, Santiago Andrés
author_sort Mul Fedele, Malena L.
title Alterations in metabolism and diurnal rhythms following bilateral surgical removal of the superior cervical ganglia in rats
title_short Alterations in metabolism and diurnal rhythms following bilateral surgical removal of the superior cervical ganglia in rats
title_full Alterations in metabolism and diurnal rhythms following bilateral surgical removal of the superior cervical ganglia in rats
title_fullStr Alterations in metabolism and diurnal rhythms following bilateral surgical removal of the superior cervical ganglia in rats
title_full_unstemmed Alterations in metabolism and diurnal rhythms following bilateral surgical removal of the superior cervical ganglia in rats
title_sort alterations in metabolism and diurnal rhythms following bilateral surgical removal of the superior cervical ganglia in rats
publisher Frontiers Media
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1466
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