Assessing the efficacy of melatonin to curtail benzodiazepine/Z drugabuse

Abstract: The abuse of benzodiazepine (BZP) and Z drugs has become, due to the tolerance and dependence theyproduce, a serious public health problem. Thirty years ago, we demonstrated in experimental animalsthe interaction of melatonin with central BZD receptors, and in 1997 we published the first s...

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Autores principales: Cardinali, Daniel Pedro, Golombek, Diego A., Rosenstein, Ruth E., Brusco, Luis I., Vigo, Daniel Eduardo
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Elsevier 2019
Materias:
MEDICINA
INSOMNIO
MELATONINA
SUEÑO
BIOMEDICINA
BENZODIACEPINAS
ABUSO DE DROGAS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1465
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1465
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic MEDICINA
INSOMNIO
MELATONINA
SUEÑO
BIOMEDICINA
BENZODIACEPINAS
ABUSO DE DROGAS
spellingShingle MEDICINA
INSOMNIO
MELATONINA
SUEÑO
BIOMEDICINA
BENZODIACEPINAS
ABUSO DE DROGAS
Cardinali, Daniel Pedro
Golombek, Diego A.
Rosenstein, Ruth E.
Brusco, Luis I.
Vigo, Daniel Eduardo
Assessing the efficacy of melatonin to curtail benzodiazepine/Z drugabuse
topic_facet MEDICINA
INSOMNIO
MELATONINA
SUEÑO
BIOMEDICINA
BENZODIACEPINAS
ABUSO DE DROGAS
description Abstract: The abuse of benzodiazepine (BZP) and Z drugs has become, due to the tolerance and dependence theyproduce, a serious public health problem. Thirty years ago, we demonstrated in experimental animalsthe interaction of melatonin with central BZD receptors, and in 1997 we published the first series ofelderly patients who reduced BZP consumption after melatonin treatment. Almost every single neuron inthe hypothalamic suprachiasmatic nuclei (SCN), the central pacemaker of the circadian system, contains-aminobutyric acid (GABA) and many results in animals point out to a melatonin interaction with GABA-containing neurons. In addition, central-type BZD antagonism, that obliterates GABAAreceptor function,blunted most behavioral effects of melatonin including sleep. Melatonin is involved in the regulation ofhuman sleep. This is supported by the temporal relationship between the rise of plasma melatonin levelsand sleep propensity as well as by the sleep-promoting effects of exogenously administered melatonin.Both meta-analyses and consensus agreements give support to the therapeutic use of melatonin in sleepdisorders. This action is attributed to MT1and MT2melatoninergic receptors localized in the SCN, as wellas in other brain areas. This review discusses available data on the efficacy of melatonin to curtail chronicBZD/Z drug use in insomnia patients. A major advantage is that melatonin has a very safe profile, it isusually remarkably well tolerated and, in some studies, it has been administered to patients at very largedoses and for long periods of time, without any potentiality of abuse. Further studies on this applicationof melatonin are warranted.
format Artículo
author Cardinali, Daniel Pedro
Golombek, Diego A.
Rosenstein, Ruth E.
Brusco, Luis I.
Vigo, Daniel Eduardo
author_facet Cardinali, Daniel Pedro
Golombek, Diego A.
Rosenstein, Ruth E.
Brusco, Luis I.
Vigo, Daniel Eduardo
author_sort Cardinali, Daniel Pedro
title Assessing the efficacy of melatonin to curtail benzodiazepine/Z drugabuse
title_short Assessing the efficacy of melatonin to curtail benzodiazepine/Z drugabuse
title_full Assessing the efficacy of melatonin to curtail benzodiazepine/Z drugabuse
title_fullStr Assessing the efficacy of melatonin to curtail benzodiazepine/Z drugabuse
title_full_unstemmed Assessing the efficacy of melatonin to curtail benzodiazepine/Z drugabuse
title_sort assessing the efficacy of melatonin to curtail benzodiazepine/z drugabuse
publisher Elsevier
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1465
work_keys_str_mv AT cardinalidanielpedro assessingtheefficacyofmelatonintocurtailbenzodiazepinezdrugabuse
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AT rosensteinruthe assessingtheefficacyofmelatonintocurtailbenzodiazepinezdrugabuse
AT bruscoluisi assessingtheefficacyofmelatonintocurtailbenzodiazepinezdrugabuse
AT vigodanieleduardo assessingtheefficacyofmelatonintocurtailbenzodiazepinezdrugabuse
bdutipo_str Repositorios
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