Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease

Abstract: Early neuropathological changes characteristic of late-onset Alzheimer’s disease (LOAD) involve brain stem and limbic structures that regulate neurovegetative functions, including sleep–wake rhythm. Indeed, sleep pattern is an emerging biomarker and a potential pathophysiological mechanism...

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Autores principales: Abulafia, Carolina Andrea, Duarte-Abritta, Bárbara, Villareal, Mirta F., Ladrón-de-Guevara, María S., García, Celeste, Sequeyra, Geraldine, Sevlever, Gustavo, Fiorentini, Leticia, Bär, Karl-Jürgen, Gustafson, Deborah R., Vigo, Daniel Eduardo, Guinjoan, Salvador M.
Formato: Artículo
Lenguaje:Español
Inglés
Publicado: Frontiers Media 2019
Materias:
ENFERMEDAD DE ALZHEIMER
PROCESO COGNITIVO
SUEÑO
RITMO CIRCADIANO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1463
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1463
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Español
Inglés
topic ENFERMEDAD DE ALZHEIMER
PROCESO COGNITIVO
SUEÑO
RITMO CIRCADIANO
spellingShingle ENFERMEDAD DE ALZHEIMER
PROCESO COGNITIVO
SUEÑO
RITMO CIRCADIANO
Abulafia, Carolina Andrea
Duarte-Abritta, Bárbara
Villareal, Mirta F.
Ladrón-de-Guevara, María S.
García, Celeste
Sequeyra, Geraldine
Sevlever, Gustavo
Fiorentini, Leticia
Bär, Karl-Jürgen
Gustafson, Deborah R.
Vigo, Daniel Eduardo
Guinjoan, Salvador M.
Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease
topic_facet ENFERMEDAD DE ALZHEIMER
PROCESO COGNITIVO
SUEÑO
RITMO CIRCADIANO
description Abstract: Early neuropathological changes characteristic of late-onset Alzheimer’s disease (LOAD) involve brain stem and limbic structures that regulate neurovegetative functions, including sleep–wake rhythm. Indeed, sleep pattern is an emerging biomarker and a potential pathophysiological mechanism in LOAD. We hypothesized that cognitively asymptomatic, middle-aged offspring of patients with LOAD (O-LOAD) would display a series of circadian rhythm abnormalities prior to the onset of objective cognitive alterations. We tested 31 children of patients with LOAD (O-LOAD) and 19 healthy individuals without family history of Alzheimer’s disease (control subjects, CS) with basic tests of cognitive function, as well as actigraphy measures of sleep–wake rhythm, cardiac autonomic function, and bodily temperature. Unexpectedly, O-LOAD displayed subtle but significant deficits in verbal episodic memory (Rey Auditory Verbal Learning Test delayed recall 10.6 ± 0.4 vs. 8.6 ± 0.6, t D 4.97, df D 49, p < 0.01) and language (Weschler’s vocabulary 51.4 ± 1.3 vs. 44.3 ± 1.5, t D 2.49, df D 49, p < 0.001) compared to CS, even though all participants had results within the clinically normal range. O-LOAD showed a phase-delayed rhythm of body temperature (2.56 ± 0.47 h vs. 3.8 ± 0.26 h, t D 2.48, df D 40, p D 0.031). Cognitive performance in O-LOAD was associated with a series of cardiac autonomic sleep–wake variables; specifically indicators of greater sympathetic activity at night were related to poorer cognition. The present results suggest sleep pattern deserves further study as a potential neurobiological signature in LOAD, even in middle-aged, at risk individuals.
format Artículo
author Abulafia, Carolina Andrea
Duarte-Abritta, Bárbara
Villareal, Mirta F.
Ladrón-de-Guevara, María S.
García, Celeste
Sequeyra, Geraldine
Sevlever, Gustavo
Fiorentini, Leticia
Bär, Karl-Jürgen
Gustafson, Deborah R.
Vigo, Daniel Eduardo
Guinjoan, Salvador M.
author_facet Abulafia, Carolina Andrea
Duarte-Abritta, Bárbara
Villareal, Mirta F.
Ladrón-de-Guevara, María S.
García, Celeste
Sequeyra, Geraldine
Sevlever, Gustavo
Fiorentini, Leticia
Bär, Karl-Jürgen
Gustafson, Deborah R.
Vigo, Daniel Eduardo
Guinjoan, Salvador M.
author_sort Abulafia, Carolina Andrea
title Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease
title_short Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease
title_full Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease
title_fullStr Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease
title_full_unstemmed Relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease
title_sort relationship between cognitive and sleep–wake variables in asymptomatic offspring of patients with late-onset alzheimer’s disease
publisher Frontiers Media
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1463
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