Cortical thickness, brain metabolic activity, and in vivo amyloid deposition in asymptomatic, middle-aged offspring of patients with late-onset Alzheimer's disease

Abstract: The natural history of preclinical late-onset Alzheimer's disease (LOAD) remains obscure and has received less attention than that of early-onset AD (EOAD), in spite of accounting for more than 99% of cases of AD. With the purpose of detecting early structural and functional traits as...

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Autores principales: Duarte-Abritta, Bárbara, Villareal, Mirta F., Abulafia, Carolina Andrea, Loewenstein, David A., Curiel-Cid, Rosie, Castro, Mariana N., Surace, Ezequiel, Sánchez, Stella M., Vigo, Daniel Eduardo, Vázquez, Silvia, Nemeroff, Charles B., Sevlever, Gustavo, Guinjoan, Salvador M.
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Elsevier 2019
Materias:
MEDICINA
ENFERMEDAD DE ALZHEIMER
CEREBRO
BIOMEDICINA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1461
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1461
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic MEDICINA
ENFERMEDAD DE ALZHEIMER
CEREBRO
BIOMEDICINA
spellingShingle MEDICINA
ENFERMEDAD DE ALZHEIMER
CEREBRO
BIOMEDICINA
Duarte-Abritta, Bárbara
Villareal, Mirta F.
Abulafia, Carolina Andrea
Loewenstein, David A.
Curiel-Cid, Rosie
Castro, Mariana N.
Surace, Ezequiel
Sánchez, Stella M.
Vigo, Daniel Eduardo
Vázquez, Silvia
Nemeroff, Charles B.
Sevlever, Gustavo
Guinjoan, Salvador M.
Cortical thickness, brain metabolic activity, and in vivo amyloid deposition in asymptomatic, middle-aged offspring of patients with late-onset Alzheimer's disease
topic_facet MEDICINA
ENFERMEDAD DE ALZHEIMER
CEREBRO
BIOMEDICINA
description Abstract: The natural history of preclinical late-onset Alzheimer's disease (LOAD) remains obscure and has received less attention than that of early-onset AD (EOAD), in spite of accounting for more than 99% of cases of AD. With the purpose of detecting early structural and functional traits associated with the disorder, we sought to characterize cortical thickness and subcortical grey matter volume, cerebral metabolism, and amyloid deposition in persons at risk for LOAD in comparison with a similar group without family history of AD. We obtained 3T T1 images for gray matter volume, FDG-PET to evaluate regional cerebral metabolism, and PET-PiB to detect fibrillar amyloid deposition in 30 middle-aged, asymptomatic, cognitively normal individuals with one parent diagnosed with LOAD (O-LOAD), and 25 comparable controls (CS) without family history of neurodegenerative disorders (CS). We observed isocortical thinning in AD-relevant areas including posterior cingulate, precuneus, and areas of the prefrontal and temporoparietal cortex in O-LOAD. Unexpectedly, this group displayed increased cerebral metabolism, in some cases overlapping with the areas of cortical thinning, and no differences in bilateral hippocampal volume and hippocampal metabolism. Given the importance of age in this sample of individuals potentially developing early AD-related changes, we controlled results for age and observed that most differences in cortical thickness and metabolism became nonsignificant; however, greater deposition of β-amyloid was observed in the right hemisphere including temporoparietal cortex, postcentral gyrus, fusiform inferior and middle temporal and lingual gyri. If replicated, the present observations of morphological, metabolic, and amyloid changes in cognitively normal persons with family history of LOAD may bear important implications for the definition of very early phenotypes of this disorder.
format Artículo
author Duarte-Abritta, Bárbara
Villareal, Mirta F.
Abulafia, Carolina Andrea
Loewenstein, David A.
Curiel-Cid, Rosie
Castro, Mariana N.
Surace, Ezequiel
Sánchez, Stella M.
Vigo, Daniel Eduardo
Vázquez, Silvia
Nemeroff, Charles B.
Sevlever, Gustavo
Guinjoan, Salvador M.
author_facet Duarte-Abritta, Bárbara
Villareal, Mirta F.
Abulafia, Carolina Andrea
Loewenstein, David A.
Curiel-Cid, Rosie
Castro, Mariana N.
Surace, Ezequiel
Sánchez, Stella M.
Vigo, Daniel Eduardo
Vázquez, Silvia
Nemeroff, Charles B.
Sevlever, Gustavo
Guinjoan, Salvador M.
author_sort Duarte-Abritta, Bárbara
title Cortical thickness, brain metabolic activity, and in vivo amyloid deposition in asymptomatic, middle-aged offspring of patients with late-onset Alzheimer's disease
title_short Cortical thickness, brain metabolic activity, and in vivo amyloid deposition in asymptomatic, middle-aged offspring of patients with late-onset Alzheimer's disease
title_full Cortical thickness, brain metabolic activity, and in vivo amyloid deposition in asymptomatic, middle-aged offspring of patients with late-onset Alzheimer's disease
title_fullStr Cortical thickness, brain metabolic activity, and in vivo amyloid deposition in asymptomatic, middle-aged offspring of patients with late-onset Alzheimer's disease
title_full_unstemmed Cortical thickness, brain metabolic activity, and in vivo amyloid deposition in asymptomatic, middle-aged offspring of patients with late-onset Alzheimer's disease
title_sort cortical thickness, brain metabolic activity, and in vivo amyloid deposition in asymptomatic, middle-aged offspring of patients with late-onset alzheimer's disease
publisher Elsevier
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1461
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