Melatonin, mitochondria, and the metabolic syndrome

Abstract: A number of risk factors for cardiovascular disease including hyperinsulinemia, glucose intolerance, dyslipidemia, obesity, and elevated blood pressure are collectively known as metabolic syndrome (MS). Since mitochondrial activity is modulated by the availability of energy in cells, the d...

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Detalles Bibliográficos
Autores principales: Cardinali, Daniel Pedro, Vigo, Daniel Eduardo
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Springer International Publishing 2019
Materias:
MEDICINA
MELATONINA
DIABETES
OBESIDAD
SINDROME METABOLICO
MITOCONDRIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1458
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1458
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic MEDICINA
MELATONINA
DIABETES
OBESIDAD
SINDROME METABOLICO
MITOCONDRIA
spellingShingle MEDICINA
MELATONINA
DIABETES
OBESIDAD
SINDROME METABOLICO
MITOCONDRIA
Cardinali, Daniel Pedro
Vigo, Daniel Eduardo
Melatonin, mitochondria, and the metabolic syndrome
topic_facet MEDICINA
MELATONINA
DIABETES
OBESIDAD
SINDROME METABOLICO
MITOCONDRIA
description Abstract: A number of risk factors for cardiovascular disease including hyperinsulinemia, glucose intolerance, dyslipidemia, obesity, and elevated blood pressure are collectively known as metabolic syndrome (MS). Since mitochondrial activity is modulated by the availability of energy in cells, the disruption of key regulators of metabolism in MS not only affects the activity of mitochondria but also their dynamics and turnover. Therefore, a link of MS with mitochondrial dysfunction has been suspected since long. As a chronobiotic/cytoprotective agent, melatonin has a special place in prevention and treatment of MS. Melatonin levels are reduced in diseases associated with insulin resistance like MS. Melatonin improves sleep efficiency and has antioxidant and anti-inflammatory properties, partly for its role as a metabolic regulator and mitochondrial protector. We discuss in the present review the several cytoprotective melatonin actions that attenuate inflammatory responses in MS. The clinical data that support the potential therapeutical value of melatonin in human MS are reviewed.
format Artículo
author Cardinali, Daniel Pedro
Vigo, Daniel Eduardo
author_facet Cardinali, Daniel Pedro
Vigo, Daniel Eduardo
author_sort Cardinali, Daniel Pedro
title Melatonin, mitochondria, and the metabolic syndrome
title_short Melatonin, mitochondria, and the metabolic syndrome
title_full Melatonin, mitochondria, and the metabolic syndrome
title_fullStr Melatonin, mitochondria, and the metabolic syndrome
title_full_unstemmed Melatonin, mitochondria, and the metabolic syndrome
title_sort melatonin, mitochondria, and the metabolic syndrome
publisher Springer International Publishing
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1458
work_keys_str_mv AT cardinalidanielpedro melatoninmitochondriaandthemetabolicsyndrome
AT vigodanieleduardo melatoninmitochondriaandthemetabolicsyndrome
bdutipo_str Repositorios
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