Failure to recover from proactive semantic interference and abnormal limbic connectivity in asymptomatic, middle-aged offspring of patients with late-onset Alzheimer’s disease

Background: We have obtained previous evidence of limbic dysfunction in middle-aged, asymptomatic offspring of lateonset Alzheimer’s disease (LOAD) patients, and failure to recover from proactive semantic interference has been shown to be a sensitive cognitive test in other groups at risk for LOAD....

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Autores principales: Sánchez, Stella M., Abulafia, Carolina Andrea, Duarte-Abritta, Bárbara, Ladrón de Guevara, M. Soledad, Castro, Mariana N., Drucaroff, Lucas J., Sevlever, Gustavo, Nemeroff, Charles B., Vigo, Daniel Eduardo, Loewenstein, David A., Villarreal, Mirta F., Guinjoan, Salvador M.
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: IOS Press 2019
Materias:
ENFERMEDAD DE ALZHEIMER
DETERIORO COGNITIVO
SISTEMA LIMBICO
INMUNOLOGIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1452
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1452
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic ENFERMEDAD DE ALZHEIMER
DETERIORO COGNITIVO
SISTEMA LIMBICO
INMUNOLOGIA
spellingShingle ENFERMEDAD DE ALZHEIMER
DETERIORO COGNITIVO
SISTEMA LIMBICO
INMUNOLOGIA
Sánchez, Stella M.
Abulafia, Carolina Andrea
Duarte-Abritta, Bárbara
Ladrón de Guevara, M. Soledad
Castro, Mariana N.
Drucaroff, Lucas J.
Sevlever, Gustavo
Nemeroff, Charles B.
Vigo, Daniel Eduardo
Loewenstein, David A.
Villarreal, Mirta F.
Guinjoan, Salvador M.
Failure to recover from proactive semantic interference and abnormal limbic connectivity in asymptomatic, middle-aged offspring of patients with late-onset Alzheimer’s disease
topic_facet ENFERMEDAD DE ALZHEIMER
DETERIORO COGNITIVO
SISTEMA LIMBICO
INMUNOLOGIA
description Background: We have obtained previous evidence of limbic dysfunction in middle-aged, asymptomatic offspring of lateonset Alzheimer’s disease (LOAD) patients, and failure to recover from proactive semantic interference has been shown to be a sensitive cognitive test in other groups at risk for LOAD. Objective: To assess the effects of specific proactive semantic interference deficits as they relate to functional magnetic resonance imaging (fMRI) neocortical and limbic functional connectivity in middle aged offspring of individuals with LOAD (O-LOAD) and age-equivalent controls. Methods:We examined 21O-LOADand 20 controls without family history of neurodegenerative disorders (CS) on traditional measures of cognitive functioning and the LASSI-L, a novel semantic interference test uniquely sensitive to the failure to recover from proactive interference (frPSI). Cognitive tests then were correlated to fMRI connectivity of seeds located in entorhinal cortex and anterodorsal thalamic nuclei among O-LOAD and CS participants. Results: Relative to CS, O-LOAD participants evidenced lower connectivity between entorhinal cortex and orbitofrontal, anterior cingulate, and anterior temporal cortex. In the offspring of LOAD patients, LASSI-L measures of frPSI were inversely associated with connectivity between anterodorsal thalamus and contralateral posterior cingulate. Intrusions on the task related to frPSI were inversely correlated with a widespread connectivity network involving hippocampal, insular, posterior cingulate, and dorsolateral prefrontal cortices, along with precunei and anterior thalamus in this group. Different patterns of connectivity associated with frPSI were observed among controls. Conclusion: The present results suggest that both semantic interference deficits and connectivity abnormalities might reflect limbic circuit dysfunction as a very early clinical signature of LOAD pathology, as previously demonstrated for other limbic phenotypes, such as sleep and circadian alterations.
format Artículo
author Sánchez, Stella M.
Abulafia, Carolina Andrea
Duarte-Abritta, Bárbara
Ladrón de Guevara, M. Soledad
Castro, Mariana N.
Drucaroff, Lucas J.
Sevlever, Gustavo
Nemeroff, Charles B.
Vigo, Daniel Eduardo
Loewenstein, David A.
Villarreal, Mirta F.
Guinjoan, Salvador M.
author_facet Sánchez, Stella M.
Abulafia, Carolina Andrea
Duarte-Abritta, Bárbara
Ladrón de Guevara, M. Soledad
Castro, Mariana N.
Drucaroff, Lucas J.
Sevlever, Gustavo
Nemeroff, Charles B.
Vigo, Daniel Eduardo
Loewenstein, David A.
Villarreal, Mirta F.
Guinjoan, Salvador M.
author_sort Sánchez, Stella M.
title Failure to recover from proactive semantic interference and abnormal limbic connectivity in asymptomatic, middle-aged offspring of patients with late-onset Alzheimer’s disease
title_short Failure to recover from proactive semantic interference and abnormal limbic connectivity in asymptomatic, middle-aged offspring of patients with late-onset Alzheimer’s disease
title_full Failure to recover from proactive semantic interference and abnormal limbic connectivity in asymptomatic, middle-aged offspring of patients with late-onset Alzheimer’s disease
title_fullStr Failure to recover from proactive semantic interference and abnormal limbic connectivity in asymptomatic, middle-aged offspring of patients with late-onset Alzheimer’s disease
title_full_unstemmed Failure to recover from proactive semantic interference and abnormal limbic connectivity in asymptomatic, middle-aged offspring of patients with late-onset Alzheimer’s disease
title_sort failure to recover from proactive semantic interference and abnormal limbic connectivity in asymptomatic, middle-aged offspring of patients with late-onset alzheimer’s disease
publisher IOS Press
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1452
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