Inflammaging, metabolic syndrome and melatonin : a call for treatment studies

Abstract: The metabolic syndrome (MS) is a collection of risk factors for cardiovascular disease, including obesity, hypertension, hyperinsulinemia, glucose intolerance and dyslipidemia. MS is associated with low-grade inflammation of the white adipose tissue, which can subsequently lead to insulin...

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Autores principales: Cardinali, Daniel Pedro, Hardeland, Rüdiger
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Karger Publishers 2019
Materias:
MEDICINA
MELATONINA
SINDROME METABOLICO
BIOMEDICINA
ESCLEROSIS MULTIPLE
ENVEJECIMIENTO
INFLAMACION
OBESIDAD
DIABETES
INSULINA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1450
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1450
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic MEDICINA
MELATONINA
SINDROME METABOLICO
BIOMEDICINA
ESCLEROSIS MULTIPLE
ENVEJECIMIENTO
INFLAMACION
OBESIDAD
DIABETES
INSULINA
spellingShingle MEDICINA
MELATONINA
SINDROME METABOLICO
BIOMEDICINA
ESCLEROSIS MULTIPLE
ENVEJECIMIENTO
INFLAMACION
OBESIDAD
DIABETES
INSULINA
Cardinali, Daniel Pedro
Hardeland, Rüdiger
Inflammaging, metabolic syndrome and melatonin : a call for treatment studies
topic_facet MEDICINA
MELATONINA
SINDROME METABOLICO
BIOMEDICINA
ESCLEROSIS MULTIPLE
ENVEJECIMIENTO
INFLAMACION
OBESIDAD
DIABETES
INSULINA
description Abstract: The metabolic syndrome (MS) is a collection of risk factors for cardiovascular disease, including obesity, hypertension, hyperinsulinemia, glucose intolerance and dyslipidemia. MS is associated with low-grade inflammation of the white adipose tissue, which can subsequently lead to insulin resistance, impaired glucose tolerance and diabetes. Adipocytes secrete proinflammatory cytokines as well as leptin and trigger a vicious circle which leads to additional weight gain largely as fat. The imbalance between inflammatory and anti-inflammatory signals is crucial to aging. Healthy aging can benefit from melatonin, a compound known to possess direct and indirect antioxidant properties, to have a significant protective effect on mitochondrial function, to enhance circadian rhythm amplitudes, to modulate the immune system and to exhibit neuroprotective actions. Melatonin levels decrease in the course of senescence and are more strongly reduced in diseases related to insulin resistance. This short review article analyzes the multiple protective actions of melatonin that are relevant to the attenuation of inflammatory responses and progression of inflammaging and how melatonin is effective to curtail MS in animal models of hyperadiposity. The clinical data supporting the possible therapeutical use of melatonin in human MS are also reviewed. Since attention has been focused on the development of potent melatonin analogs with prolonged effects (ramelteon, agomelatine, tasimelteon, piromelatine) and in clinical trials these analogs were administered in doses considerably higher than those usually employed for melatonin, clinical trials on melatonin in the range of 50-100 mg/day are needed to further assess its therapeutic value in MS.
format Artículo
author Cardinali, Daniel Pedro
Hardeland, Rüdiger
author_facet Cardinali, Daniel Pedro
Hardeland, Rüdiger
author_sort Cardinali, Daniel Pedro
title Inflammaging, metabolic syndrome and melatonin : a call for treatment studies
title_short Inflammaging, metabolic syndrome and melatonin : a call for treatment studies
title_full Inflammaging, metabolic syndrome and melatonin : a call for treatment studies
title_fullStr Inflammaging, metabolic syndrome and melatonin : a call for treatment studies
title_full_unstemmed Inflammaging, metabolic syndrome and melatonin : a call for treatment studies
title_sort inflammaging, metabolic syndrome and melatonin : a call for treatment studies
publisher Karger Publishers
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1450
work_keys_str_mv AT cardinalidanielpedro inflammagingmetabolicsyndromeandmelatoninacallfortreatmentstudies
AT hardelandrudiger inflammagingmetabolicsyndromeandmelatoninacallfortreatmentstudies
bdutipo_str Repositorios
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