The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies

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Abstract: In spite of considerable evidence on the regulation of immunity by thyroid hormones, the impact of the thyroid status in tumor immunity is poorly understood. Here, we evaluated the antitumor immune responses evoked in mice with different thyroid status (euthyroid, hyperthyroid, and hypothy...

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Autores principales: Sterle, Helena Andrea, Barreiro Arcos, María Laura, Valli, Eduardo, Paulazo, Maria Alejandra, Méndez Huergo, Santiago Patricio, Blidner, Ada Gabriela, Cayrol, María Florencia, Díaz Flaqué, María Celeste, Klecha, Alicia Juana, Medina, Vanina Araceli, Colombo, Lucas Luis, Rabinovich, Gabriel Adrián, Cremaschi, Graciela A.
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Springer 2019
Materias:
MEDICINA
GLANDULA TIROIDES
HORMONAS
INMUNOLOGIA
TUMORES
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1449
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1449
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic MEDICINA
GLANDULA TIROIDES
HORMONAS
INMUNOLOGIA
TUMORES
spellingShingle MEDICINA
GLANDULA TIROIDES
HORMONAS
INMUNOLOGIA
TUMORES
Sterle, Helena Andrea
Barreiro Arcos, María Laura
Valli, Eduardo
Paulazo, Maria Alejandra
Méndez Huergo, Santiago Patricio
Blidner, Ada Gabriela
Cayrol, María Florencia
Díaz Flaqué, María Celeste
Klecha, Alicia Juana
Medina, Vanina Araceli
Colombo, Lucas Luis
Rabinovich, Gabriel Adrián
Cremaschi, Graciela A.
The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies
topic_facet MEDICINA
GLANDULA TIROIDES
HORMONAS
INMUNOLOGIA
TUMORES
description Abstract: In spite of considerable evidence on the regulation of immunity by thyroid hormones, the impact of the thyroid status in tumor immunity is poorly understood. Here, we evaluated the antitumor immune responses evoked in mice with different thyroid status (euthyroid, hyperthyroid, and hypothyroid) that developed solid tumors or metastases after inoculation of syngeneic T lymphoma cells. Hyperthyroid mice showed increased tumor growth along with increased expression of cell cycle regulators compared to hypothyroid and control tumor-bearing mice. However, hypothyroid mice showed a higher frequency of metastases than the other groups. Hyperthyroid mice bearing tumors displayed a lower number of tumor-infiltrating T lymphocytes, lower percentage of functional IFN-γ-producing CD8+ T cells, and higher percentage of CD19+ B cells than euthyroid tumor-bearing mice. However, no differences were found in the distribution of lymphocyte subpopulations in tumor-draining lymph nodes (TDLNs) or spleens among different experimental groups. Interestingly, hypothyroid TDLN showed an increased percentage of regulatory T (Treg) cells, while hyperthyroid mice displayed increased number and activity of splenic NK cells, which frequency declined in spleens from hypothyroid mice. Moreover, a decreased number of splenic myeloid-derived suppressor cells (MDSCs) were found in tumor-bearing hyperthyroid mice as compared to hypothyroid or euthyroid mice. Additionally, hyperthyroid mice showed increased cytotoxic activity, which declined in hypothyroid mice. Thus, low levels of intratumoral cytotoxic activity would favor tumor local growth in hyperthyroid mice, while regional and systemic antitumor response may contribute to tumor dissemination in hypothyroid animals. Our results highlight the importance of monitoring the thyroid status in patients with T cell lymphomas.
format Artículo
author Sterle, Helena Andrea
Barreiro Arcos, María Laura
Valli, Eduardo
Paulazo, Maria Alejandra
Méndez Huergo, Santiago Patricio
Blidner, Ada Gabriela
Cayrol, María Florencia
Díaz Flaqué, María Celeste
Klecha, Alicia Juana
Medina, Vanina Araceli
Colombo, Lucas Luis
Rabinovich, Gabriel Adrián
Cremaschi, Graciela A.
author_facet Sterle, Helena Andrea
Barreiro Arcos, María Laura
Valli, Eduardo
Paulazo, Maria Alejandra
Méndez Huergo, Santiago Patricio
Blidner, Ada Gabriela
Cayrol, María Florencia
Díaz Flaqué, María Celeste
Klecha, Alicia Juana
Medina, Vanina Araceli
Colombo, Lucas Luis
Rabinovich, Gabriel Adrián
Cremaschi, Graciela A.
author_sort Sterle, Helena Andrea
title The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies
title_short The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies
title_full The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies
title_fullStr The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies
title_full_unstemmed The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies
title_sort thyroid status reprograms t cell lymphoma growth and modulates immune cell frequencies
publisher Springer
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1449
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