Thyroid hormones and their membrane receptors as therapeutic targets for T cell lymphomas

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Abstract: Thyroid hormones (THs) are important regulators of metabolism, differentiation and cell proliferation.They can modify the physiology of human and murine T cell lymphomas (TCL). These effects involvegenomic mechanisms, mediated by specific nuclear receptors (TR), as well as nongenomic mecha...

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Detalles Bibliográficos
Autores principales: Cremaschi, Graciela A., Cayrol, María Florencia, Sterle, Helena Andrea, Díaz Flaqué, María Celeste, Barreiro Arcos, María Laura
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: Elsevier 2019
Materias:
MEDICINA
INMUNOLOGIA
GLANDULA TIROIDES
HORMONAS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1445
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1445
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic MEDICINA
INMUNOLOGIA
GLANDULA TIROIDES
HORMONAS
spellingShingle MEDICINA
INMUNOLOGIA
GLANDULA TIROIDES
HORMONAS
Cremaschi, Graciela A.
Cayrol, María Florencia
Sterle, Helena Andrea
Díaz Flaqué, María Celeste
Barreiro Arcos, María Laura
Thyroid hormones and their membrane receptors as therapeutic targets for T cell lymphomas
topic_facet MEDICINA
INMUNOLOGIA
GLANDULA TIROIDES
HORMONAS
description Abstract: Thyroid hormones (THs) are important regulators of metabolism, differentiation and cell proliferation.They can modify the physiology of human and murine T cell lymphomas (TCL). These effects involvegenomic mechanisms, mediated by specific nuclear receptors (TR), as well as nongenomic mechanisms,that lead to the activation of different signaling pathways through the activation of a membrane recep-tor, the integrin v3. Therefore, THs are able to induce the survival and growth of TCL. Specifically, thesignaling induced by THs through the integrin v3 activates proliferative and angiogenic programs,mediated by the regulation of the vascular endothelial growth factor (VEGF). The genomic or pharmaco-logic inhibition of integrin v3 reduces the production of VEGF and induces cell death both in vitro andin xenograft models of human TCL.Here we review the mechanisms involved in the modulation of the physiology of TCL induced by THs,the analysis of the interaction between genomic and nongenomic actions of THs and their contribution toT cell lymphomagenesis. These actions of THs suggest a novel mechanism for the endocrine modulationof the physiopathology of TCL and they provide a potential molecular target for its treatment.
format Artículo
author Cremaschi, Graciela A.
Cayrol, María Florencia
Sterle, Helena Andrea
Díaz Flaqué, María Celeste
Barreiro Arcos, María Laura
author_facet Cremaschi, Graciela A.
Cayrol, María Florencia
Sterle, Helena Andrea
Díaz Flaqué, María Celeste
Barreiro Arcos, María Laura
author_sort Cremaschi, Graciela A.
title Thyroid hormones and their membrane receptors as therapeutic targets for T cell lymphomas
title_short Thyroid hormones and their membrane receptors as therapeutic targets for T cell lymphomas
title_full Thyroid hormones and their membrane receptors as therapeutic targets for T cell lymphomas
title_fullStr Thyroid hormones and their membrane receptors as therapeutic targets for T cell lymphomas
title_full_unstemmed Thyroid hormones and their membrane receptors as therapeutic targets for T cell lymphomas
title_sort thyroid hormones and their membrane receptors as therapeutic targets for t cell lymphomas
publisher Elsevier
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1445
work_keys_str_mv AT cremaschigracielaa thyroidhormonesandtheirmembranereceptorsastherapeutictargetsfortcelllymphomas
AT cayrolmariaflorencia thyroidhormonesandtheirmembranereceptorsastherapeutictargetsfortcelllymphomas
AT sterlehelenaandrea thyroidhormonesandtheirmembranereceptorsastherapeutictargetsfortcelllymphomas
AT diazflaquemariaceleste thyroidhormonesandtheirmembranereceptorsastherapeutictargetsfortcelllymphomas
AT barreiroarcosmarialaura thyroidhormonesandtheirmembranereceptorsastherapeutictargetsfortcelllymphomas
bdutipo_str Repositorios
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