Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without gamily history of late-onset Alzheimer's disease

Abstract: Failure to recover from proactive semantic interference (frPSI) has been shown to be more sensitive than traditional cognitive measures in different populations with preclinical Alzheimer’s disease. The authors sought to characterize the structural and amyloid in vivo correlates of frPSI i...

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Autores principales: Abulafia, Carolina Andrea, Loewenstein, David A., Curiel-Cid, Rosie, Duarte-Abritta, Bárbara, Sánchez, Stella M., Vigo, Daniel Eduardo, Castro, Mariana N., Drucaroff, Lucas J., Vázquez, Silvia, Sevlever, Gustavo, Nemeroff, Charles B., Guinjoan, Salvador M., Villareal, Mirta F.
Formato: Artículo
Lenguaje:Inglés
Inglés
Publicado: American Psychiatric Association 2019
Materias:
MEDICINA
ENFERMEDAD DE ALZHEIMER
MEMORIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/1437
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-1437
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
Inglés
topic MEDICINA
ENFERMEDAD DE ALZHEIMER
MEMORIA
spellingShingle MEDICINA
ENFERMEDAD DE ALZHEIMER
MEMORIA
Abulafia, Carolina Andrea
Loewenstein, David A.
Curiel-Cid, Rosie
Duarte-Abritta, Bárbara
Sánchez, Stella M.
Vigo, Daniel Eduardo
Castro, Mariana N.
Drucaroff, Lucas J.
Vázquez, Silvia
Sevlever, Gustavo
Nemeroff, Charles B.
Guinjoan, Salvador M.
Villareal, Mirta F.
Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without gamily history of late-onset Alzheimer's disease
topic_facet MEDICINA
ENFERMEDAD DE ALZHEIMER
MEMORIA
description Abstract: Failure to recover from proactive semantic interference (frPSI) has been shown to be more sensitive than traditional cognitive measures in different populations with preclinical Alzheimer’s disease. The authors sought to characterize the structural and amyloid in vivo correlates of frPSI in cognitively normal offspring of patients with late-onset Alzheimer’s disease (O-LOAD), compared with individuals without a family history of neurodegenerative disorders (CS). The authors evaluated the LASSI-L, a test tapping frPSI and other types of semantic interference and delayed recall on the RAVLT, along with 3-T MRI volumetry and positron emission tomography Pittsburgh compound B, in 27 O-LOAD and 18 CS with equivalent age, sex, years of education, ethnicity, premorbid intelligence, and mood symptoms. Recovery from proactive semantic interference (frPSI) and RAVLT delayed recall were lower in O-LOAD cases. Structural correlates of both cognitive dimensions were different in CS and O-LOAD, involving brain regions concerned with autonomic, motor, and motivational control in the former, and regions traditionally implicated in Alzheimer’s disease in the latter. Better recovery from retroactive semantic interference was associated with less amyloid load in the left temporal lobe in O-LOAD but not CS. In middle-aged cognitively normal individuals with one parent affected with LOAD, frPSI was impaired compared with persons without a family history of LOAD. The neuroimaging correlates of such cognitive measure in those with one parent with LOAD involve Alzheimer’s-relevant brain regions even at a relatively young age.
format Artículo
author Abulafia, Carolina Andrea
Loewenstein, David A.
Curiel-Cid, Rosie
Duarte-Abritta, Bárbara
Sánchez, Stella M.
Vigo, Daniel Eduardo
Castro, Mariana N.
Drucaroff, Lucas J.
Vázquez, Silvia
Sevlever, Gustavo
Nemeroff, Charles B.
Guinjoan, Salvador M.
Villareal, Mirta F.
author_facet Abulafia, Carolina Andrea
Loewenstein, David A.
Curiel-Cid, Rosie
Duarte-Abritta, Bárbara
Sánchez, Stella M.
Vigo, Daniel Eduardo
Castro, Mariana N.
Drucaroff, Lucas J.
Vázquez, Silvia
Sevlever, Gustavo
Nemeroff, Charles B.
Guinjoan, Salvador M.
Villareal, Mirta F.
author_sort Abulafia, Carolina Andrea
title Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without gamily history of late-onset Alzheimer's disease
title_short Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without gamily history of late-onset Alzheimer's disease
title_full Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without gamily history of late-onset Alzheimer's disease
title_fullStr Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without gamily history of late-onset Alzheimer's disease
title_full_unstemmed Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without gamily history of late-onset Alzheimer's disease
title_sort brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without gamily history of late-onset alzheimer's disease
publisher American Psychiatric Association
publishDate 2019
url https://repositorio.uca.edu.ar/handle/123456789/1437
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