A preliminary study of low-dose angiotensin 1-7 plus the pineal hormone melatonin in the treatment of human systemic diseases other than cancer and autoimmune pathologies

Abstract: The recent advances of the psychoneuroimmunology have demonstrated the existence of a physiological anti-inflammatory antitumor neuroendocrine axis, mainly constituted by the pineal gland through its indole hormone melatonin (MLT) and the ACE2-angiotensin 1-7 (Ang 1-7) system. Moreover,...

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Autores principales: Lissoni, Paolo, Porta, Enrica, Rovelli, Franco, Messina, Giusy, Lissoni, Arianna, Porro, Giorgio, Porro, Davide, Di Fede, Giuseppe, Monzon, Alejandra, Sassola, Andrea, Cardinali, Daniel Pedro
Formato: Artículo
Lenguaje:Inglés
Publicado: Sryahwa 2022
Materias:
ANGIOTENSINA 1-7
ENZIMAS
ENFERMEDADES CEREBROVASCULARES
ENFERMEDADES NEURODEGENERATIVAS
GLANDULA PINEAL
SINDROME METABOLICO
CARDIOPATIAS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/13684
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-13684
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ANGIOTENSINA 1-7
ENZIMAS
ENFERMEDADES CEREBROVASCULARES
ENFERMEDADES NEURODEGENERATIVAS
GLANDULA PINEAL
SINDROME METABOLICO
CARDIOPATIAS
spellingShingle ANGIOTENSINA 1-7
ENZIMAS
ENFERMEDADES CEREBROVASCULARES
ENFERMEDADES NEURODEGENERATIVAS
GLANDULA PINEAL
SINDROME METABOLICO
CARDIOPATIAS
Lissoni, Paolo
Porta, Enrica
Rovelli, Franco
Messina, Giusy
Lissoni, Arianna
Porro, Giorgio
Porro, Davide
Di Fede, Giuseppe
Monzon, Alejandra
Sassola, Andrea
Cardinali, Daniel Pedro
A preliminary study of low-dose angiotensin 1-7 plus the pineal hormone melatonin in the treatment of human systemic diseases other than cancer and autoimmune pathologies
topic_facet ANGIOTENSINA 1-7
ENZIMAS
ENFERMEDADES CEREBROVASCULARES
ENFERMEDADES NEURODEGENERATIVAS
GLANDULA PINEAL
SINDROME METABOLICO
CARDIOPATIAS
description Abstract: The recent advances of the psychoneuroimmunology have demonstrated the existence of a physiological anti-inflammatory antitumor neuroendocrine axis, mainly constituted by the pineal gland through its indole hormone melatonin (MLT) and the ACE2-angiotensin 1-7 (Ang 1-7) system. Moreover, most human systemic diseases, including cancer, autoimmunity, metabolic, cardiovascular, and neurodegenerative pathologies, have appeared to be characterized by an endogenous deficiency in the functionless of the pineal gland and ACEACE2 system. Therefore, the exogenous correction of MLT and Ang 1-7 deficiency could improve the clinical control of human systemic diseases. On these bases, a preliminary study of MLT plus Ang 1-7 was planned in patients suffering from systemic alterations other than cancer and autoimmunity. The study included 33 consecutive patients, whose pathologies were, as follows: cardiovascular pathologies: 9; pulmonary diseases: 7; metabolic syndrome: 7; neurodegenerative pathologies: 10. Both Ang 1-7 and MLT were given orally, at a dose of 0.5 mg/day in the morning for Ang 1-7, and at a dose of 10 mg/day in the evening for MLT. The treatment was well tolerated in all patients, and no-therapy related toxicity occurred. On the contrary, most patients experienced a relief of anxiety and asthenia, and an improvement in both mood and quality of sleep. Moreover, most patients referred an increased diuresis. Blood pressure values progressively became within the normal range in hypertensive patients. On the same way, glucose and cholesterol levels progressively decrease on therapy in diabetic and hypercholesterolemic patients, respectively. Patients with pulmonary disturbance referred an important enhancement in the expectoration, with a following improvement in the respiratory symptomatology. Finally, an apparent improvement in cognitive and motor functions was achieved in patients with neurodegenerative pathologies. These preliminary results would suggest a future medical possibility to treat the human systemicdiseases by simply correcting their endogenous neuroendocrine deficiencies, mainly those involving the functions of the pineal gland and ACE2-Ang1-7 system.
format Artículo
author Lissoni, Paolo
Porta, Enrica
Rovelli, Franco
Messina, Giusy
Lissoni, Arianna
Porro, Giorgio
Porro, Davide
Di Fede, Giuseppe
Monzon, Alejandra
Sassola, Andrea
Cardinali, Daniel Pedro
author_facet Lissoni, Paolo
Porta, Enrica
Rovelli, Franco
Messina, Giusy
Lissoni, Arianna
Porro, Giorgio
Porro, Davide
Di Fede, Giuseppe
Monzon, Alejandra
Sassola, Andrea
Cardinali, Daniel Pedro
author_sort Lissoni, Paolo
title A preliminary study of low-dose angiotensin 1-7 plus the pineal hormone melatonin in the treatment of human systemic diseases other than cancer and autoimmune pathologies
title_short A preliminary study of low-dose angiotensin 1-7 plus the pineal hormone melatonin in the treatment of human systemic diseases other than cancer and autoimmune pathologies
title_full A preliminary study of low-dose angiotensin 1-7 plus the pineal hormone melatonin in the treatment of human systemic diseases other than cancer and autoimmune pathologies
title_fullStr A preliminary study of low-dose angiotensin 1-7 plus the pineal hormone melatonin in the treatment of human systemic diseases other than cancer and autoimmune pathologies
title_full_unstemmed A preliminary study of low-dose angiotensin 1-7 plus the pineal hormone melatonin in the treatment of human systemic diseases other than cancer and autoimmune pathologies
title_sort preliminary study of low-dose angiotensin 1-7 plus the pineal hormone melatonin in the treatment of human systemic diseases other than cancer and autoimmune pathologies
publisher Sryahwa
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/13684
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bdutipo_str Repositorios
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