Low melatonin as a contributor to SARS-CoV-2 disease

Abstract: That the pineal gland is a source of melatonin is widely known; however, by comparison, few know of the much larger pool of extrapineal melatonin. That pool is widely distributed in all animals, including those that do not have a pineal gland, e.g., insects. Extrapineal melatonin is not...

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Autores principales: Pandi Perumal, Seithikurippu R., Cardinali, Daniel Pedro, Reiter, R., Brown, Gregory M.
Formato: Artículo
Lenguaje:Inglés
Publicado: 2022
Materias:
COVID-19
SARS-CoV-2
CORONAVIRUS
MELATONINA
MITOCONDRIAS
CITOQUINAS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/13680
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-13680
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic COVID-19
SARS-CoV-2
CORONAVIRUS
MELATONINA
MITOCONDRIAS
CITOQUINAS
spellingShingle COVID-19
SARS-CoV-2
CORONAVIRUS
MELATONINA
MITOCONDRIAS
CITOQUINAS
Pandi Perumal, Seithikurippu R.
Cardinali, Daniel Pedro
Reiter, R.
Brown, Gregory M.
Low melatonin as a contributor to SARS-CoV-2 disease
topic_facet COVID-19
SARS-CoV-2
CORONAVIRUS
MELATONINA
MITOCONDRIAS
CITOQUINAS
description Abstract: That the pineal gland is a source of melatonin is widely known; however, by comparison, few know of the much larger pool of extrapineal melatonin. That pool is widely distributed in all animals, including those that do not have a pineal gland, e.g., insects. Extrapineal melatonin is not released into the blood but is used locally to function as an antioxidant, anti-inflammatory agent, etc. A major site of action of peripherally-produced melatonin is the mitochondria where it neutralizes reactive oxygen species (ROS) that are generated during oxidative phosphorylation. Its role also includes major actions as an immune modulator reducing overreactions to foreign agents while simultaneously boosting immune processes. During a pandemic such as coronavirus disease 2019 (COVID-19), caused by the virus SARS-CoV-2, melatonin is capable of suppressing the damage inflicted by the cytokine storm. The implications of melatonin in susceptibility and treatment of COVID-19 disease are discussed.
format Artículo
author Pandi Perumal, Seithikurippu R.
Cardinali, Daniel Pedro
Reiter, R.
Brown, Gregory M.
author_facet Pandi Perumal, Seithikurippu R.
Cardinali, Daniel Pedro
Reiter, R.
Brown, Gregory M.
author_sort Pandi Perumal, Seithikurippu R.
title Low melatonin as a contributor to SARS-CoV-2 disease
title_short Low melatonin as a contributor to SARS-CoV-2 disease
title_full Low melatonin as a contributor to SARS-CoV-2 disease
title_fullStr Low melatonin as a contributor to SARS-CoV-2 disease
title_full_unstemmed Low melatonin as a contributor to SARS-CoV-2 disease
title_sort low melatonin as a contributor to sars-cov-2 disease
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/13680
work_keys_str_mv AT pandiperumalseithikurippur lowmelatoninasacontributortosarscov2disease
AT cardinalidanielpedro lowmelatoninasacontributortosarscov2disease
AT reiterr lowmelatoninasacontributortosarscov2disease
AT browngregorym lowmelatoninasacontributortosarscov2disease
bdutipo_str Repositorios
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