How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach
Abstract: Recent advances in the area of the psycho-neuroendocrine-immunology have demonstrated that the inflammatory and immune reactions depend not only on immune factors, but also, they are under an intricate neuroendocrine regulation. In turn, the activity of the nervous and endocrine systems...
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| Formato: | Artículo |
| Lenguaje: | Inglés |
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Crimson
2022
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| Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/13679 |
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I33-R139123456789-13679 |
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dspace |
| institution |
Universidad Católica Argentina |
| institution_str |
I-33 |
| repository_str |
R-139 |
| collection |
Repositorio Institucional de la Universidad Católica Argentina (UCA) |
| language |
Inglés |
| topic |
CANNABINOIDES CANCER COVID-19 CITOQUINAS MELATONINA NEUROPROTECCION INMUNOLOGIA SISTEMA INMUNOLOGICO |
| spellingShingle |
CANNABINOIDES CANCER COVID-19 CITOQUINAS MELATONINA NEUROPROTECCION INMUNOLOGIA SISTEMA INMUNOLOGICO Lissoni, Paolo Brivio, Fernando Fumagalli, Luca Rovelli, Franco Colciago, Massimo Messina, Giusy Monzon, Alejandra Pelizzoni, Francesco Lissoni, Arianna Porro, Giorgio Di Fede, Giuseppe Cardinali, Daniel Pedro How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach |
| topic_facet |
CANNABINOIDES CANCER COVID-19 CITOQUINAS MELATONINA NEUROPROTECCION INMUNOLOGIA SISTEMA INMUNOLOGICO |
| description |
Abstract: Recent advances in the area of the psycho-neuroendocrine-immunology have demonstrated that the
inflammatory and immune reactions depend not only on immune factors, but also, they are under an
intricate neuroendocrine regulation. In turn, the activity of the nervous and endocrine systems is affected
by immune-inflammatory signals. Although most hormones and neuromodulators can potentially
influence the immune function, main immunomodulatory properties seem to be exerted by opioid and
cannabinoid systems. Brain opioid and cannabinoid systems are endocrinologically connected to the
adrenal, and to the pineal gland, respectively. In addition, the neurohypophysis is also important for
the neuroimmunomodulation through the release of vasopressin and oxytocin. Experimental evidence
supports the conclusion that two fundamental functional circuits occur, including a brain opioid
system-vasopressin-adrenal axis, characterized by a prevalent immunosuppressive activity, and a brain
cannabinoid-oxytocin-pineal axis, which exerts an immunostimulatory role. The latter is relevant mainly
for anticancer immunity. The opioid-adrenal functional axis is active in stress and depressive conditions,
while the cannabinoid-pineal axis has been proven to be involved in pleasure perception and spiritual
expansion of mind. The findings could explain the predisposition to severe systemic diseases played by
stress and depression, and on the other hand the protective action of pleasure and spirituality in the onset
of important pathologies. The clinical and therapeutic applications of these concepts may constitute a
landmark for future Medicine. |
| format |
Artículo |
| author |
Lissoni, Paolo Brivio, Fernando Fumagalli, Luca Rovelli, Franco Colciago, Massimo Messina, Giusy Monzon, Alejandra Pelizzoni, Francesco Lissoni, Arianna Porro, Giorgio Di Fede, Giuseppe Cardinali, Daniel Pedro |
| author_facet |
Lissoni, Paolo Brivio, Fernando Fumagalli, Luca Rovelli, Franco Colciago, Massimo Messina, Giusy Monzon, Alejandra Pelizzoni, Francesco Lissoni, Arianna Porro, Giorgio Di Fede, Giuseppe Cardinali, Daniel Pedro |
| author_sort |
Lissoni, Paolo |
| title |
How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach |
| title_short |
How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach |
| title_full |
How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach |
| title_fullStr |
How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach |
| title_full_unstemmed |
How to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach |
| title_sort |
how to modulate the immunoinflammatory biological response in cancer, autoimmunity and viral infections by a psychoneuroimmune approach |
| publisher |
Crimson |
| publishDate |
2022 |
| url |
https://repositorio.uca.edu.ar/handle/123456789/13679 |
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