Can melatonin be a potential “silver bullet” in treating covid-19 patients?

Abstract: The therapeutic potential of melatonin as a chronobiotic cytoprotective agent to counteract the consequences of COVID-19 infections has been advocated. Because of its wide-ranging effects as an antioxidant, anti-inflammatory, and immunomodulatory compound, melatonin could be unique in imp...

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Autores principales: Cardinali, Daniel Pedro, Brown, Gregory M., Pandi Perumal, Seithikurippu R.
Formato: Artículo
Lenguaje:Inglés
Publicado: Multidisciplinary Digital Publishing Institute 2022
Materias:
ENVEJECIMIENTO
VACUNACION
COVID-19
SARS-CoV-2
DIABETES
INFLAMACION
SINDROME METABOLICO
MELATONINA
DETERIORO COGNITIVO
NEURODEGENERACION
ESTRES OXIDATIVO
SISTEMA RENINA-ANGIOTENSINA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/13665
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-13665
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ENVEJECIMIENTO
VACUNACION
COVID-19
SARS-CoV-2
DIABETES
INFLAMACION
SINDROME METABOLICO
MELATONINA
DETERIORO COGNITIVO
NEURODEGENERACION
ESTRES OXIDATIVO
SISTEMA RENINA-ANGIOTENSINA
spellingShingle ENVEJECIMIENTO
VACUNACION
COVID-19
SARS-CoV-2
DIABETES
INFLAMACION
SINDROME METABOLICO
MELATONINA
DETERIORO COGNITIVO
NEURODEGENERACION
ESTRES OXIDATIVO
SISTEMA RENINA-ANGIOTENSINA
Cardinali, Daniel Pedro
Brown, Gregory M.
Pandi Perumal, Seithikurippu R.
Can melatonin be a potential “silver bullet” in treating covid-19 patients?
topic_facet ENVEJECIMIENTO
VACUNACION
COVID-19
SARS-CoV-2
DIABETES
INFLAMACION
SINDROME METABOLICO
MELATONINA
DETERIORO COGNITIVO
NEURODEGENERACION
ESTRES OXIDATIVO
SISTEMA RENINA-ANGIOTENSINA
description Abstract: The therapeutic potential of melatonin as a chronobiotic cytoprotective agent to counteract the consequences of COVID-19 infections has been advocated. Because of its wide-ranging effects as an antioxidant, anti-inflammatory, and immunomodulatory compound, melatonin could be unique in impairing the consequences of SARS-CoV-2 infection. Moreover, indirect evidence points out to a possible antiviral action of melatonin by interfering with SARS-CoV-2/angiotensin-converting enzyme 2 association. Melatonin is also an effective chronobiotic agent to reverse the circadian disruption of social isolation and to control delirium in severely affected patients. As a cytoprotector, melatonin serves to combat several comorbidities such as diabetes, metabolic syndrome, and ischemic and non-ischemic cardiovascular diseases, which aggravate COVID-19 disease. In view of evidence on the occurrence of neurological sequels in COVID-19-infected patients, another putative application of melatonin emerges based on its neuroprotective properties. Since melatonin is an effective means to control cognitive decay in minimal cognitive impairment, its therapeutic significance for the neurological sequels of SARS-CoV-2 infection should be considered. Finally, yet importantly, exogenous melatonin can be an adjuvant capable of augmenting the efficacy of anti-SARS-CoV-2 vaccines. We discuss in this review the experimental evidence suggesting that melatonin is a potential “silver bullet” in the COVID 19 pandemic.
format Artículo
author Cardinali, Daniel Pedro
Brown, Gregory M.
Pandi Perumal, Seithikurippu R.
author_facet Cardinali, Daniel Pedro
Brown, Gregory M.
Pandi Perumal, Seithikurippu R.
author_sort Cardinali, Daniel Pedro
title Can melatonin be a potential “silver bullet” in treating covid-19 patients?
title_short Can melatonin be a potential “silver bullet” in treating covid-19 patients?
title_full Can melatonin be a potential “silver bullet” in treating covid-19 patients?
title_fullStr Can melatonin be a potential “silver bullet” in treating covid-19 patients?
title_full_unstemmed Can melatonin be a potential “silver bullet” in treating covid-19 patients?
title_sort can melatonin be a potential “silver bullet” in treating covid-19 patients?
publisher Multidisciplinary Digital Publishing Institute
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/13665
work_keys_str_mv AT cardinalidanielpedro canmelatoninbeapotentialsilverbulletintreatingcovid19patients
AT browngregorym canmelatoninbeapotentialsilverbulletintreatingcovid19patients
AT pandiperumalseithikurippur canmelatoninbeapotentialsilverbulletintreatingcovid19patients
bdutipo_str Repositorios
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