Coronavirus-19, monocyte/macrophage glycolysis and inhibition by melatonin

Abstract: Two highly relevant studies related to SARS-CoV-2 and coronavirus disease (COVID-19) and supporting the use of melatonin to prevent and treat this serious infection were published recently. Campos-Codo and colleagues [1] documented experimentally their claim that drugs which specifica...

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Autores principales: Reiter, R., Sharma, Ramaswamy, Castillo, Rafael, Marik, Paul E., Domínguez Rodriguez, Alberto, Cardinali, Daniel Pedro, Tesarik, Jan
Formato: Artículo
Lenguaje:Inglés
Publicado: Wright Academia 2022
Materias:
SARS-CoV-2
COVID-19
MELATONINA
FARMACOLOGIA
SISTEMA RESPIRATORIO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/13642
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-13642
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic SARS-CoV-2
COVID-19
MELATONINA
FARMACOLOGIA
SISTEMA RESPIRATORIO
spellingShingle SARS-CoV-2
COVID-19
MELATONINA
FARMACOLOGIA
SISTEMA RESPIRATORIO
Reiter, R.
Sharma, Ramaswamy
Castillo, Rafael
Marik, Paul E.
Domínguez Rodriguez, Alberto
Cardinali, Daniel Pedro
Tesarik, Jan
Coronavirus-19, monocyte/macrophage glycolysis and inhibition by melatonin
topic_facet SARS-CoV-2
COVID-19
MELATONINA
FARMACOLOGIA
SISTEMA RESPIRATORIO
description Abstract: Two highly relevant studies related to SARS-CoV-2 and coronavirus disease (COVID-19) and supporting the use of melatonin to prevent and treat this serious infection were published recently. Campos-Codo and colleagues [1] documented experimentally their claim that drugs which specifically target hypoxia inducible factor-1α (HIF-1α) would likely have great therapeutic value in treating COVID-19. The second report is a retrospective analysis based on the clinical experience at the Columbia University Irving Medical Center with the use of drugs to treat respiratory distress in COVID-19-infected patients who required endotracheal intubation [2]. Hyperinflammatory monocytes/macrophages accumulate in abundance in the lower respiratory tract where they play a key role in determining the severity of SARS-CoV-2 infections. Campos-Codo, et al. [1] found that monocytes/macrophages infected with the SARSCoV-2 virus reprogram their metabolism from the conventional mitochondrial oxidative phosphorylation (OXPHOS) to the (usually) pathological cytosolic glycolysis. This so-called Warburg-type metabolism is aided by the inadequately controlled elevated blood glucose levels of diabetic patients, which enhances cellular glycolysis, viral replication and hastens development of a severe respiratory infection resulting from the elevated cytokine release (“cytokine storm”).
format Artículo
author Reiter, R.
Sharma, Ramaswamy
Castillo, Rafael
Marik, Paul E.
Domínguez Rodriguez, Alberto
Cardinali, Daniel Pedro
Tesarik, Jan
author_facet Reiter, R.
Sharma, Ramaswamy
Castillo, Rafael
Marik, Paul E.
Domínguez Rodriguez, Alberto
Cardinali, Daniel Pedro
Tesarik, Jan
author_sort Reiter, R.
title Coronavirus-19, monocyte/macrophage glycolysis and inhibition by melatonin
title_short Coronavirus-19, monocyte/macrophage glycolysis and inhibition by melatonin
title_full Coronavirus-19, monocyte/macrophage glycolysis and inhibition by melatonin
title_fullStr Coronavirus-19, monocyte/macrophage glycolysis and inhibition by melatonin
title_full_unstemmed Coronavirus-19, monocyte/macrophage glycolysis and inhibition by melatonin
title_sort coronavirus-19, monocyte/macrophage glycolysis and inhibition by melatonin
publisher Wright Academia
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/13642
work_keys_str_mv AT reiterr coronavirus19monocytemacrophageglycolysisandinhibitionbymelatonin
AT sharmaramaswamy coronavirus19monocytemacrophageglycolysisandinhibitionbymelatonin
AT castillorafael coronavirus19monocytemacrophageglycolysisandinhibitionbymelatonin
AT marikpaule coronavirus19monocytemacrophageglycolysisandinhibitionbymelatonin
AT dominguezrodriguezalberto coronavirus19monocytemacrophageglycolysisandinhibitionbymelatonin
AT cardinalidanielpedro coronavirus19monocytemacrophageglycolysisandinhibitionbymelatonin
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bdutipo_str Repositorios
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