Efficacy of melatonin in non-intensive care unit patients with COVID-19 pneumonia and sleep dysregulation

Abstract: The association of sleep disruption with a higher vulnerability to COVID-19 infection is a subject of major clinical importance. In patients with pneumonia associated with COVID-19 admitted to non-intensive care unit (NICU) several factors, like the disrupting influence of respiratory dist...

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Detalles Bibliográficos
Autores principales: Brusco, Luis I., Cruz, Pablo, Cangas, Alicia V., González Rojas, Carmen, Vigo, Daniel Eduardo, Cardinali, Daniel Pedro
Formato: Artículo
Lenguaje:Inglés
Publicado: Biolife LLC 2022
Materias:
CRONOBIOLOGIA
MELATONINA
COVID-19
PANDEMIA
NEUMONIA
SUEÑO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/13637
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-13637
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic CRONOBIOLOGIA
MELATONINA
COVID-19
PANDEMIA
NEUMONIA
SUEÑO
spellingShingle CRONOBIOLOGIA
MELATONINA
COVID-19
PANDEMIA
NEUMONIA
SUEÑO
Brusco, Luis I.
Cruz, Pablo
Cangas, Alicia V.
González Rojas, Carmen
Vigo, Daniel Eduardo
Cardinali, Daniel Pedro
Efficacy of melatonin in non-intensive care unit patients with COVID-19 pneumonia and sleep dysregulation
topic_facet CRONOBIOLOGIA
MELATONINA
COVID-19
PANDEMIA
NEUMONIA
SUEÑO
description Abstract: The association of sleep disruption with a higher vulnerability to COVID-19 infection is a subject of major clinical importance. In patients with pneumonia associated with COVID-19 admitted to non-intensive care unit (NICU) several factors, like the disrupting influence of respiratory distress, medication, greater stress due to social isolation, and lack of appropriate exposure to environmental light can be instrumental to disrupt sleep/wake cycle. The therapeutic potential of melatonin to counteract the consequences of COVID-19 infection has been advocated. Because of its wide-ranging effects as an antioxidant, anti-inflammatory, and immunomodulatory compound, melatonin could be unique in impairing the consequences of SARS-CoV-2 infection. Melatonin is also an effective chronobiotic agent to reverse the circadian disruption of social isolation and to control delirium in severely affected patients. Properly administered, melatonin may restore the optimal circadian pattern of the sleep-wake cycle and improve clinical condition in pneumonia associated with COVID-19 patients. The present review article discusses the importance of maintaining normal sleep and circadian rhythmicity in NICU patients and provides preliminary data suggesting the efficacy of melatonin (9 mg/day) to reduce length of stay of pneumonia patients associated with COVID-19 in NICU.
format Artículo
author Brusco, Luis I.
Cruz, Pablo
Cangas, Alicia V.
González Rojas, Carmen
Vigo, Daniel Eduardo
Cardinali, Daniel Pedro
author_facet Brusco, Luis I.
Cruz, Pablo
Cangas, Alicia V.
González Rojas, Carmen
Vigo, Daniel Eduardo
Cardinali, Daniel Pedro
author_sort Brusco, Luis I.
title Efficacy of melatonin in non-intensive care unit patients with COVID-19 pneumonia and sleep dysregulation
title_short Efficacy of melatonin in non-intensive care unit patients with COVID-19 pneumonia and sleep dysregulation
title_full Efficacy of melatonin in non-intensive care unit patients with COVID-19 pneumonia and sleep dysregulation
title_fullStr Efficacy of melatonin in non-intensive care unit patients with COVID-19 pneumonia and sleep dysregulation
title_full_unstemmed Efficacy of melatonin in non-intensive care unit patients with COVID-19 pneumonia and sleep dysregulation
title_sort efficacy of melatonin in non-intensive care unit patients with covid-19 pneumonia and sleep dysregulation
publisher Biolife LLC
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/13637
work_keys_str_mv AT bruscoluisi efficacyofmelatonininnonintensivecareunitpatientswithcovid19pneumoniaandsleepdysregulation
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