Structural and functional motor-network disruptions predict selective action-concept deficits: Evidence from frontal lobe epilepsy

Abstract: Built on neurodegenerative lesions models, the disrupted motor grounding hypothesis (DMGH) posits that motor-system alterations selectively impair action comprehension. However, major doubts remain concerning the dissociability, neural signatures, and etiological generalizability of suc...

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Autores principales: Moguilner, Sebastian, Birba, Agustina, Fino, Daniel, Huetagoyena, Celeste, Otoya, Raúl, Tirapu, Viviana, Cremaschi, Fabián, Sedeño, Lucas, Ibáñez, Agustín, García, Adolfo M., Isoardi, Roberto
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier 2022
Materias:
EPILEPSIA
MACHINE LEARNING
CONDUCTA
FUNCIONES MOTORAS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/13411
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-13411
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic EPILEPSIA
MACHINE LEARNING
CONDUCTA
FUNCIONES MOTORAS
spellingShingle EPILEPSIA
MACHINE LEARNING
CONDUCTA
FUNCIONES MOTORAS
Moguilner, Sebastian
Birba, Agustina
Fino, Daniel
Huetagoyena, Celeste
Otoya, Raúl
Tirapu, Viviana
Cremaschi, Fabián
Sedeño, Lucas
Ibáñez, Agustín
García, Adolfo M.
Isoardi, Roberto
Structural and functional motor-network disruptions predict selective action-concept deficits: Evidence from frontal lobe epilepsy
topic_facet EPILEPSIA
MACHINE LEARNING
CONDUCTA
FUNCIONES MOTORAS
description Abstract: Built on neurodegenerative lesions models, the disrupted motor grounding hypothesis (DMGH) posits that motor-system alterations selectively impair action comprehension. However, major doubts remain concerning the dissociability, neural signatures, and etiological generalizability of such deficits. Few studies have compared action-concept outcomes between disorders affecting and sparing motor circuitry, and none has examined their multimodal network predictors via data-driven approaches. Here, we first assessed action- and object-concept processing in patients with frontal lobe epilepsy (FLE), patients with posterior cortex epilepsy (PCE), and healthy controls. Then, we examined structural and functional network signatures via diffusion tensor imaging and resting-state connectivity measures. Finally, we used these measures to predict behavioral performance with an XGBoost machine learning regression algorithm. Relative to controls, FLE (but not PCE) patients exhibited selective action-concept deficits together with structural and functional abnormalities along motor networks. The XGBoost model reached a significantly large effect size only for action-concept outcomes in FLE, mainly predicted by structural (cortico-spinal tract, anterior thalamic radiation, uncinate fasciculus) and functional (M1- parietal/supramarginal connectivity) motor networks. These results extend the DMGH, suggesting that action-concept deficits are dissociable markers of frontal/motor (relative to posterior) disruptions, directly related to the structural and functional integrity of motor networks, and traceable beyond canonical movement disorders.
format Artículo
author Moguilner, Sebastian
Birba, Agustina
Fino, Daniel
Huetagoyena, Celeste
Otoya, Raúl
Tirapu, Viviana
Cremaschi, Fabián
Sedeño, Lucas
Ibáñez, Agustín
García, Adolfo M.
Isoardi, Roberto
author_facet Moguilner, Sebastian
Birba, Agustina
Fino, Daniel
Huetagoyena, Celeste
Otoya, Raúl
Tirapu, Viviana
Cremaschi, Fabián
Sedeño, Lucas
Ibáñez, Agustín
García, Adolfo M.
Isoardi, Roberto
author_sort Moguilner, Sebastian
title Structural and functional motor-network disruptions predict selective action-concept deficits: Evidence from frontal lobe epilepsy
title_short Structural and functional motor-network disruptions predict selective action-concept deficits: Evidence from frontal lobe epilepsy
title_full Structural and functional motor-network disruptions predict selective action-concept deficits: Evidence from frontal lobe epilepsy
title_fullStr Structural and functional motor-network disruptions predict selective action-concept deficits: Evidence from frontal lobe epilepsy
title_full_unstemmed Structural and functional motor-network disruptions predict selective action-concept deficits: Evidence from frontal lobe epilepsy
title_sort structural and functional motor-network disruptions predict selective action-concept deficits: evidence from frontal lobe epilepsy
publisher Elsevier
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/13411
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