Interleukin-1 links autoimmune and autoinflammatory pathophysiology in mixed-pattern psoriasis

Abstract: Autoinflammatory and autoimmune diseases are characterized by an oversensitive immune system with loss of the physiological endogenous regulation, involving multifactorial self-reactive pathological mechanisms of mono- or polygenic nature. Failure in regulatory mechanisms triggers a comp...

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Detalles Bibliográficos
Autores principales: Kölliker Frers, Rodolfo, Otero Losada, Matilde, Kobiec, Tamara, Herrera, María Inés, Udovin, Lucas Daniel, Kusnier, Carlos Federico, Capani, Francisco
Formato: Artículo
Lenguaje:Inglés
Publicado: Hidawi 2021
Materias:
PSORIASIS
ENFERMEDADES AUTOINMUNES
INTERLEUKIN-1
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/12546
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-12546
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic PSORIASIS
ENFERMEDADES AUTOINMUNES
INTERLEUKIN-1
spellingShingle PSORIASIS
ENFERMEDADES AUTOINMUNES
INTERLEUKIN-1
Kölliker Frers, Rodolfo
Otero Losada, Matilde
Kobiec, Tamara
Herrera, María Inés
Udovin, Lucas Daniel
Kusnier, Carlos Federico
Capani, Francisco
Interleukin-1 links autoimmune and autoinflammatory pathophysiology in mixed-pattern psoriasis
topic_facet PSORIASIS
ENFERMEDADES AUTOINMUNES
INTERLEUKIN-1
description Abstract: Autoinflammatory and autoimmune diseases are characterized by an oversensitive immune system with loss of the physiological endogenous regulation, involving multifactorial self-reactive pathological mechanisms of mono- or polygenic nature. Failure in regulatory mechanisms triggers a complex network of dynamic relationships between innate and adaptive immunity, leading to coexistent autoinflammatory and autoimmune processes. Sustained exposure to a trigger or a genetic alteration at the level of the receptors of the natural immune system may lead to abnormal activation of the innate immune system, adaptive system activation, loss of self-tolerance, and systemic inflammation. The IL-1 family members critically activate and regulate innate and adaptive immune responses’ diversity and plasticity in autoimmune and/or autoinflammatory conditions. The IL-23/IL-17 axis is key in the communication between innate immunity (IL-23-producing myeloid cells) and adaptive immunity (Th17- and IL-17-expressing CD8+ T cells). In psoriasis, these cytokines are decisive to the different clinical presentations, whether as plaque psoriasis (psoriasis vulgaris), generalized pustular psoriasis (pustular psoriasis), or mixed forms. These forms reflect a gradient between autoimmune pathophysiology with predominant adaptive immune response and autoinflammatory pathophysiology with predominant innate immune response.
format Artículo
author Kölliker Frers, Rodolfo
Otero Losada, Matilde
Kobiec, Tamara
Herrera, María Inés
Udovin, Lucas Daniel
Kusnier, Carlos Federico
Capani, Francisco
author_facet Kölliker Frers, Rodolfo
Otero Losada, Matilde
Kobiec, Tamara
Herrera, María Inés
Udovin, Lucas Daniel
Kusnier, Carlos Federico
Capani, Francisco
author_sort Kölliker Frers, Rodolfo
title Interleukin-1 links autoimmune and autoinflammatory pathophysiology in mixed-pattern psoriasis
title_short Interleukin-1 links autoimmune and autoinflammatory pathophysiology in mixed-pattern psoriasis
title_full Interleukin-1 links autoimmune and autoinflammatory pathophysiology in mixed-pattern psoriasis
title_fullStr Interleukin-1 links autoimmune and autoinflammatory pathophysiology in mixed-pattern psoriasis
title_full_unstemmed Interleukin-1 links autoimmune and autoinflammatory pathophysiology in mixed-pattern psoriasis
title_sort interleukin-1 links autoimmune and autoinflammatory pathophysiology in mixed-pattern psoriasis
publisher Hidawi
publishDate 2021
url https://repositorio.uca.edu.ar/handle/123456789/12546
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bdutipo_str Repositorios
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