Immunomodulation induced by central nervous system-related peptides as a therapeutic strategy for neurodegenerative disorders

Mostrar todas las versiones(2)

Abstract: Neurodegenerative diseases (NDD) are disorders characterized by the progressive loss of neurons affecting motor, sensory, and/or cognitive functions. The incidence of these diseases is increasing and has a great impact due to their high morbidity and mortality. Unfortunately, current th...

Descripción completa

Detalles Bibliográficos
Autores principales: Palumbo, María Laura, Moroni, Alejandro David, Quiroga, Sofia, Castro, María Micaela, Burgueño, Adriana, Genaro, Ana María
Formato: Artículo
Lenguaje:Inglés
Publicado: John Wiley & Sons Ltd British Pharmacological Society 2021
Materias:
NEURODEGENERACION
SISTEMA NERVIOSO CENTRAL
ENFERMEDADES NEURODEGENERATIVAS
SISTEMA INMUNOLOGICO
NEUROPROTECCION
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/12481
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-12481
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic NEURODEGENERACION
SISTEMA NERVIOSO CENTRAL
ENFERMEDADES NEURODEGENERATIVAS
SISTEMA INMUNOLOGICO
NEUROPROTECCION
spellingShingle NEURODEGENERACION
SISTEMA NERVIOSO CENTRAL
ENFERMEDADES NEURODEGENERATIVAS
SISTEMA INMUNOLOGICO
NEUROPROTECCION
Palumbo, María Laura
Moroni, Alejandro David
Quiroga, Sofia
Castro, María Micaela
Burgueño, Adriana
Genaro, Ana María
Immunomodulation induced by central nervous system-related peptides as a therapeutic strategy for neurodegenerative disorders
topic_facet NEURODEGENERACION
SISTEMA NERVIOSO CENTRAL
ENFERMEDADES NEURODEGENERATIVAS
SISTEMA INMUNOLOGICO
NEUROPROTECCION
description Abstract: Neurodegenerative diseases (NDD) are disorders characterized by the progressive loss of neurons affecting motor, sensory, and/or cognitive functions. The incidence of these diseases is increasing and has a great impact due to their high morbidity and mortality. Unfortunately, current therapeutic strategies only temporarily improve the patients’ quality of life but are insufficient for completely alleviating the symptoms. An interaction between the immune system and the central nervous system (CNS) is widely associated with neuronal damage in NDD. Usually, immune cell infiltration has been identified with inflammation and is considered harmful to the injured CNS. However, the immune system has a crucial role in the protection and regeneration of the injured CNS. Nowadays, there is a consensus that deregulation of immune homeostasis may represent one of the key initial steps in NDD. Dr. Michal Schwartz originally conceived the concept of “protective autoimmunity” (PA) as a well-controlled peripheral inflammatory reaction after injury, essential for neuroprotection and regeneration. Several studies suggested that immunizing with a weaker version of the neural self-antigen would generate PA without degenerative autoimmunity. The development of CNS-related peptides with immunomodulatory neuroprotective effect led to important research to evaluate their use in chronic and acute NDD. In this review, we refer to the role of PA and the potential applications of active immunization as a therapeutic option for NDD treatment. In particular, we focus on the experimental and clinical promissory findings for CNS-related peptides with beneficial immunomodulatory effects.
format Artículo
author Palumbo, María Laura
Moroni, Alejandro David
Quiroga, Sofia
Castro, María Micaela
Burgueño, Adriana
Genaro, Ana María
author_facet Palumbo, María Laura
Moroni, Alejandro David
Quiroga, Sofia
Castro, María Micaela
Burgueño, Adriana
Genaro, Ana María
author_sort Palumbo, María Laura
title Immunomodulation induced by central nervous system-related peptides as a therapeutic strategy for neurodegenerative disorders
title_short Immunomodulation induced by central nervous system-related peptides as a therapeutic strategy for neurodegenerative disorders
title_full Immunomodulation induced by central nervous system-related peptides as a therapeutic strategy for neurodegenerative disorders
title_fullStr Immunomodulation induced by central nervous system-related peptides as a therapeutic strategy for neurodegenerative disorders
title_full_unstemmed Immunomodulation induced by central nervous system-related peptides as a therapeutic strategy for neurodegenerative disorders
title_sort immunomodulation induced by central nervous system-related peptides as a therapeutic strategy for neurodegenerative disorders
publisher John Wiley & Sons Ltd British Pharmacological Society
publishDate 2021
url https://repositorio.uca.edu.ar/handle/123456789/12481
work_keys_str_mv AT palumbomarialaura immunomodulationinducedbycentralnervoussystemrelatedpeptidesasatherapeuticstrategyforneurodegenerativedisorders
AT moronialejandrodavid immunomodulationinducedbycentralnervoussystemrelatedpeptidesasatherapeuticstrategyforneurodegenerativedisorders
AT quirogasofia immunomodulationinducedbycentralnervoussystemrelatedpeptidesasatherapeuticstrategyforneurodegenerativedisorders
AT castromariamicaela immunomodulationinducedbycentralnervoussystemrelatedpeptidesasatherapeuticstrategyforneurodegenerativedisorders
AT burguenoadriana immunomodulationinducedbycentralnervoussystemrelatedpeptidesasatherapeuticstrategyforneurodegenerativedisorders
AT genaroanamaria immunomodulationinducedbycentralnervoussystemrelatedpeptidesasatherapeuticstrategyforneurodegenerativedisorders
bdutipo_str Repositorios
_version_ 1764820525925793793

Ejemplares similares