Contribution of TRPC channels in neuronal excitotoxicity associated with neurodegenerative disease and ischemic stroke
Abstract: The seven canonical members of transient receptor potential (TRPC) proteins form cation channels that evoke membrane depolarization and intracellular calcium concentration ([Ca2C]i) rise, which are not only important for regulating cell function but their deregulation can also lead to c...
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| Formato: | Artículo |
| Lenguaje: | Inglés |
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Lausanne: Frontiers Media
2021
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| Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/11624 |
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I33-R139123456789-11624 |
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dspace |
| institution |
Universidad Católica Argentina |
| institution_str |
I-33 |
| repository_str |
R-139 |
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Repositorio Institucional de la Universidad Católica Argentina (UCA) |
| language |
Inglés |
| topic |
TRCP FISIOPATOLOGÍA ENFERMEDADES NEURODEGENERATIVAS ACCIDENTE CEREBROVASCULAR LESION CEREBRAL |
| spellingShingle |
TRCP FISIOPATOLOGÍA ENFERMEDADES NEURODEGENERATIVAS ACCIDENTE CEREBROVASCULAR LESION CEREBRAL Jeon, Jaepyo Bu, Fan Sun, Guanghua Tian, Jin-Bin Ting, Shun-Ming Li, Jun Aronowski, Jaroslaw Birnbaumer, Lutz Freichel, Marc Zhu, Michael X. Contribution of TRPC channels in neuronal excitotoxicity associated with neurodegenerative disease and ischemic stroke |
| topic_facet |
TRCP FISIOPATOLOGÍA ENFERMEDADES NEURODEGENERATIVAS ACCIDENTE CEREBROVASCULAR LESION CEREBRAL |
| description |
Abstract: The seven canonical members of transient receptor potential (TRPC) proteins
form cation channels that evoke membrane depolarization and intracellular calcium
concentration ([Ca2C]i) rise, which are not only important for regulating cell function
but their deregulation can also lead to cell damage. Recent studies have implicated
complex roles of TRPC channels in neurodegenerative diseases including ischemic
stroke. Brain ischemia reduces oxygen and glucose supply to neurons, i.e., Oxygen
and Glucose Deprivation (OGD), resulting in [Ca2C]i elevation, ion dyshomeostasis, and
excitotoxicity, which are also common in many forms of neurodegenerative diseases.
Although ionotropic glutamate receptors, e.g., N-methyl-D-aspartate receptors, are
well established to play roles in excitotoxicity, the contribution of metabotropic
glutamate receptors and their downstream effectors, i.e., TRPC channels, should
not be neglected. Here, we summarize the current findings about contributions of
TRPC channels in neurodegenerative diseases, with a focus on OGD-induced neuronal
death and rodent models of cerebral ischemia/reperfusion. TRPC channels play both
detrimental and protective roles to neurodegeneration depending on the TRPC subtype
and specific pathological conditions involved. When illustrated the mechanisms by
which TRPC channels are involved in neuronal survival or death seem differ greatly,
implicating diverse and complex regulation. We provide our own data showing that
TRPC1/C4/C5, especially TRPC4, may be generally detrimental in OGD and cerebral
ischemia/reperfusion. We propose that although TRPC channels significantly contribute
to ischemic neuronal death, detailed mechanisms and specific roles of TRPC subtypes
in brain injury at different stages of ischemia/reperfusion and in different brain regions
need to be carefully and systematically investigated. |
| format |
Artículo |
| author |
Jeon, Jaepyo Bu, Fan Sun, Guanghua Tian, Jin-Bin Ting, Shun-Ming Li, Jun Aronowski, Jaroslaw Birnbaumer, Lutz Freichel, Marc Zhu, Michael X. |
| author_facet |
Jeon, Jaepyo Bu, Fan Sun, Guanghua Tian, Jin-Bin Ting, Shun-Ming Li, Jun Aronowski, Jaroslaw Birnbaumer, Lutz Freichel, Marc Zhu, Michael X. |
| author_sort |
Jeon, Jaepyo |
| title |
Contribution of TRPC channels in neuronal excitotoxicity associated with neurodegenerative disease and ischemic stroke |
| title_short |
Contribution of TRPC channels in neuronal excitotoxicity associated with neurodegenerative disease and ischemic stroke |
| title_full |
Contribution of TRPC channels in neuronal excitotoxicity associated with neurodegenerative disease and ischemic stroke |
| title_fullStr |
Contribution of TRPC channels in neuronal excitotoxicity associated with neurodegenerative disease and ischemic stroke |
| title_full_unstemmed |
Contribution of TRPC channels in neuronal excitotoxicity associated with neurodegenerative disease and ischemic stroke |
| title_sort |
contribution of trpc channels in neuronal excitotoxicity associated with neurodegenerative disease and ischemic stroke |
| publisher |
Lausanne: Frontiers Media |
| publishDate |
2021 |
| url |
https://repositorio.uca.edu.ar/handle/123456789/11624 |
| work_keys_str_mv |
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Repositorios |
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