Influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in BALB/c mice

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Abstract: Prenatal insults during fetal development result in increased likelihood of developing chronic disease. Obesity, the biggest risk factor for the development of metabolic disease, is affected by several genetic and environmental factors. High-fat diet (HFD) consumption is usually linked...

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Autores principales: Juárez, Yamila R., Quiroga, Sofía, Prochnik, Andrés, Wald, Miriam Ruth, Tellechea, Mariana L., Genaro, Ana María, Burgueño, Adriana
Formato: Artículo
Lenguaje:Inglés
Publicado: Cambridge University Press 2021
Materias:
STRESS PRENATAL
OBESIDAD
METABOLISMO
GENES
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/11564
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-11564
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic STRESS PRENATAL
OBESIDAD
METABOLISMO
GENES
spellingShingle STRESS PRENATAL
OBESIDAD
METABOLISMO
GENES
Juárez, Yamila R.
Quiroga, Sofía
Prochnik, Andrés
Wald, Miriam Ruth
Tellechea, Mariana L.
Genaro, Ana María
Burgueño, Adriana
Influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in BALB/c mice
topic_facet STRESS PRENATAL
OBESIDAD
METABOLISMO
GENES
description Abstract: Prenatal insults during fetal development result in increased likelihood of developing chronic disease. Obesity, the biggest risk factor for the development of metabolic disease, is affected by several genetic and environmental factors. High-fat diet (HFD) consumption is usually linked with the development of obesity. The main goal of this study was to analyze the impact of the exposure to a HFD in prenatally stressed animals. For this purpose, we subjected pregnant BALB/c mice to restraint stress for 2 h a day between gestational day (GD) 14 and GD 21. Prenatally stressed and control offspring of both sexes were postnatally exposed to a HFD for 24 weeks. We found that prenatal stress (PS) per se produced disturbances in males such as increased total blood cholesterol and triglycerides, with a decrease in mRNA expression of sirtuin-1.When these animals were fed a HFD, we observed a rise in glucose and insulin levels and an increase in visceral adipose tissue gene expression of leptin, resistin, and interleukin-1 beta. Although females proved to be more resilient to PS consequences, when they were fed a HFD, they showed significant metabolic impairment. In addition to the changes observed in males, females also presented an increase in body weight and adiposity and a rise in cholesterol levels.
format Artículo
author Juárez, Yamila R.
Quiroga, Sofía
Prochnik, Andrés
Wald, Miriam Ruth
Tellechea, Mariana L.
Genaro, Ana María
Burgueño, Adriana
author_facet Juárez, Yamila R.
Quiroga, Sofía
Prochnik, Andrés
Wald, Miriam Ruth
Tellechea, Mariana L.
Genaro, Ana María
Burgueño, Adriana
author_sort Juárez, Yamila R.
title Influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in BALB/c mice
title_short Influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in BALB/c mice
title_full Influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in BALB/c mice
title_fullStr Influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in BALB/c mice
title_full_unstemmed Influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in BALB/c mice
title_sort influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in balb/c mice
publisher Cambridge University Press
publishDate 2021
url https://repositorio.uca.edu.ar/handle/123456789/11564
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