Structural biology of coronavirus ion channels

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Abstract: Viral infection compromises specific organelles of the cell and readdresses its functional resources to satisfy the needs of the invading body. Around 70% of the coronavirus positive-sense single-stranded RNA encodes proteins involved in replication, and these viruses essentially take o...

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Autor principal: Barrantes, Francisco José
Formato: Artículo
Lenguaje:Inglés
Publicado: C. S. Bond, University of Western Australia, Crawley, Australia 2021
Materias:
MEDICINA
BIOLOGIA
CORONAVIRUS
COVID-19
SARS-CoV-2
CANALES IONICOS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/11364
https://doi.org/10.1107/S2059798321001431
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-11364
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic MEDICINA
BIOLOGIA
CORONAVIRUS
COVID-19
SARS-CoV-2
CANALES IONICOS
spellingShingle MEDICINA
BIOLOGIA
CORONAVIRUS
COVID-19
SARS-CoV-2
CANALES IONICOS
Barrantes, Francisco José
Structural biology of coronavirus ion channels
topic_facet MEDICINA
BIOLOGIA
CORONAVIRUS
COVID-19
SARS-CoV-2
CANALES IONICOS
description Abstract: Viral infection compromises specific organelles of the cell and readdresses its functional resources to satisfy the needs of the invading body. Around 70% of the coronavirus positive-sense single-stranded RNA encodes proteins involved in replication, and these viruses essentially take over the biosynthetic and transport mechanisms to ensure the efficient replication of their genome and trafficking of their virions. Some coronaviruses encode genes for ion-channel proteins – the envelope protein E (orf4a), orf3a and orf8 – which they successfully employ to take control of the endoplasmic reticulum–Golgi complex intermediate compartment or ERGIC. The E protein, which is one of the four structural proteins of SARS-CoV-2 and other coronaviruses, assembles its transmembrane protomers into homopentameric channels with mild cationic selectivity. Orf3a forms homodimers and homotetramers. Both carry a PDZ-binding domain, lending them the versatility to interact with more than 400 target proteins in infected host cells. Orf8 is a very short 29-amino-acid single-passage transmembrane peptide that forms cation-selective channels when assembled in lipid bilayers. This review addresses the contribution of biophysical and structural biology approaches that unravel different facets of coronavirus ion channels, their effects on the cellular machinery of infected cells and some structure–functional correlations with ion channels of higher organisms.
format Artículo
author Barrantes, Francisco José
author_facet Barrantes, Francisco José
author_sort Barrantes, Francisco José
title Structural biology of coronavirus ion channels
title_short Structural biology of coronavirus ion channels
title_full Structural biology of coronavirus ion channels
title_fullStr Structural biology of coronavirus ion channels
title_full_unstemmed Structural biology of coronavirus ion channels
title_sort structural biology of coronavirus ion channels
publisher C. S. Bond, University of Western Australia, Crawley, Australia
publishDate 2021
url https://repositorio.uca.edu.ar/handle/123456789/11364
https://doi.org/10.1107/S2059798321001431
work_keys_str_mv AT barrantesfranciscojose structuralbiologyofcoronavirusionchannels
bdutipo_str Repositorios
_version_ 1764820524689522688

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