Long-term effects of hypoxia-reoxygenation on thioredoxins in rat central nervous system

Abstract: Oxidative stress induced by the oxidative pathway dysregulation following ischemia/reperfusion has been proposed as an important cause of neuronal death and brain damage. The proteins of the thioredoxin (Trx) family are crucial mediators of protein function regulating the intracellular h...

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Detalles Bibliográficos
Autores principales: Otero Losada, Matilde, Canepa, Leonardo, Udovin, Lucas Daniel, Kobiec, Tamara, Toro-Urrego, Nicolás, Kölliker Frers, Rodolfo, Capani, Francisco
Formato: Artículo
Lenguaje:Inglés
Publicado: Bentham Science Publisher 2021
Materias:
HIPOXIA
ISQUEMIA
SISTEMA NERVIOSO CENTRAL
PROTEINAS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/11346
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-11346
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic HIPOXIA
ISQUEMIA
SISTEMA NERVIOSO CENTRAL
PROTEINAS
spellingShingle HIPOXIA
ISQUEMIA
SISTEMA NERVIOSO CENTRAL
PROTEINAS
Otero Losada, Matilde
Canepa, Leonardo
Udovin, Lucas Daniel
Kobiec, Tamara
Toro-Urrego, Nicolás
Kölliker Frers, Rodolfo
Capani, Francisco
Long-term effects of hypoxia-reoxygenation on thioredoxins in rat central nervous system
topic_facet HIPOXIA
ISQUEMIA
SISTEMA NERVIOSO CENTRAL
PROTEINAS
description Abstract: Oxidative stress induced by the oxidative pathway dysregulation following ischemia/reperfusion has been proposed as an important cause of neuronal death and brain damage. The proteins of the thioredoxin (Trx) family are crucial mediators of protein function regulating the intracellular hydrogen peroxide levels and redoxsensitive post-translational protein changes. This study evaluates the long-term effects of common carotid artery ligation-induced ischemia/reperfusion on the protein expression and distribution of fourteen members of the Trx family and related proteins (Grx1, Grx2, Grx3, Grx5, Prx1, Prx2, Prx3, Prx4, Prx5, Prx6, Trx1, Trx2, TrxR1, TrxR2) in the most hypoxia susceptible rat brain areas, namely, cerebellum, corpus striatum, and the hippocampus. The thioredoxin proteins displayed a complex, cell-type, and tissue-specific expression pattern following ischemia/reperfusion.
format Artículo
author Otero Losada, Matilde
Canepa, Leonardo
Udovin, Lucas Daniel
Kobiec, Tamara
Toro-Urrego, Nicolás
Kölliker Frers, Rodolfo
Capani, Francisco
author_facet Otero Losada, Matilde
Canepa, Leonardo
Udovin, Lucas Daniel
Kobiec, Tamara
Toro-Urrego, Nicolás
Kölliker Frers, Rodolfo
Capani, Francisco
author_sort Otero Losada, Matilde
title Long-term effects of hypoxia-reoxygenation on thioredoxins in rat central nervous system
title_short Long-term effects of hypoxia-reoxygenation on thioredoxins in rat central nervous system
title_full Long-term effects of hypoxia-reoxygenation on thioredoxins in rat central nervous system
title_fullStr Long-term effects of hypoxia-reoxygenation on thioredoxins in rat central nervous system
title_full_unstemmed Long-term effects of hypoxia-reoxygenation on thioredoxins in rat central nervous system
title_sort long-term effects of hypoxia-reoxygenation on thioredoxins in rat central nervous system
publisher Bentham Science Publisher
publishDate 2021
url https://repositorio.uca.edu.ar/handle/123456789/11346
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bdutipo_str Repositorios
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