The role of nicotinic cholinergic neurotransmission in delusional thinking

Abstract: Delusions are a difficult-to-treat and intellectually fascinating aspect of many psychiatric illnesses. Although scientific progress on this complex topic has been challenging, some recent advances focus on dysfunction in neural circuits, specifically in those involving dopaminergic and...

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Detalles Bibliográficos
Autores principales: Caton, Michael, Ochoa, Enrique L. M., Barrantes, Francisco José
Formato: Artículo
Lenguaje:Inglés
Publicado: Nature Research 2020
Materias:
MEDICINA
PSIQUIATRIA
DELIRIO
NEUROTRANSMISORES
TRATAMIENTO MEDICO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/10850
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-10850
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic MEDICINA
PSIQUIATRIA
DELIRIO
NEUROTRANSMISORES
TRATAMIENTO MEDICO
spellingShingle MEDICINA
PSIQUIATRIA
DELIRIO
NEUROTRANSMISORES
TRATAMIENTO MEDICO
Caton, Michael
Ochoa, Enrique L. M.
Barrantes, Francisco José
The role of nicotinic cholinergic neurotransmission in delusional thinking
topic_facet MEDICINA
PSIQUIATRIA
DELIRIO
NEUROTRANSMISORES
TRATAMIENTO MEDICO
description Abstract: Delusions are a difficult-to-treat and intellectually fascinating aspect of many psychiatric illnesses. Although scientific progress on this complex topic has been challenging, some recent advances focus on dysfunction in neural circuits, specifically in those involving dopaminergic and glutamatergic neurotransmission. Here we review the role of cholinergic neurotransmission in delusions, with a focus on nicotinic receptors, which are known to play a part in some illnesses where these symptoms appear, including delirium, schizophrenia spectrum disorders, bipolar disorder, Parkinson, Huntington, and Alzheimer diseases. Beginning with what we know about the emergence of delusions in these illnesses, we advance a hypothesis of cholinergic disturbance in the dorsal striatum where nicotinic receptors are operative. Striosomes are proposed to play a central role in the formation of delusions. This hypothesis is consistent with our current knowledge about the mechanism of action of cholinergic drugs and with our abstract models of basic cognitive mechanisms at the molecular and circuit levels. We conclude by pointing out the need for further research both at the clinical and translational levels.
format Artículo
author Caton, Michael
Ochoa, Enrique L. M.
Barrantes, Francisco José
author_facet Caton, Michael
Ochoa, Enrique L. M.
Barrantes, Francisco José
author_sort Caton, Michael
title The role of nicotinic cholinergic neurotransmission in delusional thinking
title_short The role of nicotinic cholinergic neurotransmission in delusional thinking
title_full The role of nicotinic cholinergic neurotransmission in delusional thinking
title_fullStr The role of nicotinic cholinergic neurotransmission in delusional thinking
title_full_unstemmed The role of nicotinic cholinergic neurotransmission in delusional thinking
title_sort role of nicotinic cholinergic neurotransmission in delusional thinking
publisher Nature Research
publishDate 2020
url https://repositorio.uca.edu.ar/handle/123456789/10850
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