Melatonin and Benzodiazepine / Z Drug Abuse

Abstract: A temporal relationship between the nocturnal rise in melatonin secretion and the increase in sleep propensity at the beginning of the night, coupled with the sleeppromoting effects of exogenous melatonin, supports the view that melatonin is involved in the regulation of sleep. Both met...

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Detalles Bibliográficos
Autores principales: Cardinali, Daniel Pedro, Vigo, Daniel Eduardo
Formato: Parte de libro
Lenguaje:Inglés
Publicado: Springer Nature 2020
Materias:
MELATONINA
BENZODIAZEPINAS
INSOMNIO
RITMO CIRCADIANO
SUEÑO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/10808
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-10808
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic MELATONINA
BENZODIAZEPINAS
INSOMNIO
RITMO CIRCADIANO
SUEÑO
spellingShingle MELATONINA
BENZODIAZEPINAS
INSOMNIO
RITMO CIRCADIANO
SUEÑO
Cardinali, Daniel Pedro
Vigo, Daniel Eduardo
Melatonin and Benzodiazepine / Z Drug Abuse
topic_facet MELATONINA
BENZODIAZEPINAS
INSOMNIO
RITMO CIRCADIANO
SUEÑO
description Abstract: A temporal relationship between the nocturnal rise in melatonin secretion and the increase in sleep propensity at the beginning of the night, coupled with the sleeppromoting effects of exogenous melatonin, supports the view that melatonin is involved in the regulation of sleep. Both meta-analyses and consensus agreements give credibility to the therapeutic use of melatonin in sleep disorders. Administration of melatonin will cue the circadian phase of sleep/wake cycles in a variety of disorders including jet lag problems, shift work maladaptation, advanced and delayed sleep phase disorders, major affective disorder, seasonal affective disorder and disrupted rhythms in attention deficit hyperactivity disorder, autism, and schizophrenia. This action is attributed to MT1 and MT2 melatonin receptors present in the hypothalamic suprachiasmatic nucleus (SCN) and in other brain areas. Almost every single neuron in the SCN contains GABA and many results in animals point out to a melatonin interaction with GABA-containing neurons. In addition, central-type benzodiazepine (BZD) antagonism, that obliterates GABAA receptor function, blunted melatonin behavioral effects including sleep. The sleep promoting activity of melatonin is relevant because the BZD and type Z drugs usually prescribed as sleep promoters have many adverse effects, such as next-day hangover, dependence and impairment of memory. This Chapter discusses available data on the efficacy of melatonin to curtail chronic BZD/ Z drug use in insomnia patients.
format Parte de libro
author Cardinali, Daniel Pedro
Vigo, Daniel Eduardo
author_facet Cardinali, Daniel Pedro
Vigo, Daniel Eduardo
author_sort Cardinali, Daniel Pedro
title Melatonin and Benzodiazepine / Z Drug Abuse
title_short Melatonin and Benzodiazepine / Z Drug Abuse
title_full Melatonin and Benzodiazepine / Z Drug Abuse
title_fullStr Melatonin and Benzodiazepine / Z Drug Abuse
title_full_unstemmed Melatonin and Benzodiazepine / Z Drug Abuse
title_sort melatonin and benzodiazepine / z drug abuse
publisher Springer Nature
publishDate 2020
url https://repositorio.uca.edu.ar/handle/123456789/10808
work_keys_str_mv AT cardinalidanielpedro melatoninandbenzodiazepinezdrugabuse
AT vigodanieleduardo melatoninandbenzodiazepinezdrugabuse
bdutipo_str Repositorios
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