Synaptoprotection in perinatal asphyxia: an experimental approach

Perinatal asphyxia (PA) is an obstetric complication occurring when the oxygen supply to the newborn is temporally interrupted. This health problem is associated with high morbimortality in term and preterm neonates. It severely affects the brain structure and function, involving cortical, hippoc...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Herrera, María Inés, Kobiec, Tamara, Kölliker Frers, Rodolfo, Otero Losada, Matilde, Capani, Francisco
Formato: Artículo
Lenguaje:Inglés
Publicado: Frontiers 2020
Materias:
ASFIXIA NEONATAL
TRASTORNOS DEL NEURODESARROLLO
SINAPTOPATIA
PSICOPATOLOGIA
NEUROPSICOLOGIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/10801
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-10801
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ASFIXIA NEONATAL
TRASTORNOS DEL NEURODESARROLLO
SINAPTOPATIA
PSICOPATOLOGIA
NEUROPSICOLOGIA
spellingShingle ASFIXIA NEONATAL
TRASTORNOS DEL NEURODESARROLLO
SINAPTOPATIA
PSICOPATOLOGIA
NEUROPSICOLOGIA
Herrera, María Inés
Kobiec, Tamara
Kölliker Frers, Rodolfo
Otero Losada, Matilde
Capani, Francisco
Synaptoprotection in perinatal asphyxia: an experimental approach
topic_facet ASFIXIA NEONATAL
TRASTORNOS DEL NEURODESARROLLO
SINAPTOPATIA
PSICOPATOLOGIA
NEUROPSICOLOGIA
description Perinatal asphyxia (PA) is an obstetric complication occurring when the oxygen supply to the newborn is temporally interrupted. This health problem is associated with high morbimortality in term and preterm neonates. It severely affects the brain structure and function, involving cortical, hippocampal, and striatal loss of neurons. Nearly 25% of PA survivor newborns develop several neurodevelopmental disabilities. Behavioral alterations, as well as the morphological and biochemical pathways involved in PA pathophysiology, have been studied using an animal model that resembles intrauterine asphyxia. Experimental evidence shows that PA induces synaptic derangement. Then, synaptic dysfunction embodies a putative target for neuroprotective strategies. Over the last years, therapeutic hypothermia (TH), the only treatment available, has shown positive results in the clinic. Several pharmacological agents are being tested in experimental or clinical trial studies to prevent synaptopathy. Preservation of the synaptic structure and function, i.e., “synaptoprotection,” makes up a promising challenge for reducing incidental neurodevelopmental disorders associated with PA. Accordingly, here, we summarize and review the findings obtained from the referred experimental model and propose a renewed overview in the field.
format Artículo
author Herrera, María Inés
Kobiec, Tamara
Kölliker Frers, Rodolfo
Otero Losada, Matilde
Capani, Francisco
author_facet Herrera, María Inés
Kobiec, Tamara
Kölliker Frers, Rodolfo
Otero Losada, Matilde
Capani, Francisco
author_sort Herrera, María Inés
title Synaptoprotection in perinatal asphyxia: an experimental approach
title_short Synaptoprotection in perinatal asphyxia: an experimental approach
title_full Synaptoprotection in perinatal asphyxia: an experimental approach
title_fullStr Synaptoprotection in perinatal asphyxia: an experimental approach
title_full_unstemmed Synaptoprotection in perinatal asphyxia: an experimental approach
title_sort synaptoprotection in perinatal asphyxia: an experimental approach
publisher Frontiers
publishDate 2020
url https://repositorio.uca.edu.ar/handle/123456789/10801
work_keys_str_mv AT herreramariaines synaptoprotectioninperinatalasphyxiaanexperimentalapproach
AT kobiectamara synaptoprotectioninperinatalasphyxiaanexperimentalapproach
AT kollikerfrersrodolfo synaptoprotectioninperinatalasphyxiaanexperimentalapproach
AT oterolosadamatilde synaptoprotectioninperinatalasphyxiaanexperimentalapproach
AT capanifrancisco synaptoprotectioninperinatalasphyxiaanexperimentalapproach
bdutipo_str Repositorios
_version_ 1764820524941180930

Ejemplares similares