High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection

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Abstract: The therapeutic potential of melatonin as an agent to counteract the consequences of COVID-19 infections is due to its wide-ranging effects as a powerful antioxidant, anti-inflammatory, and immunostimulant, as well as to a possible antiviral action. In view of the recently reported evidenc...

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Autor principal: Cardinali, Daniel Pedro
Formato: Artículo
Lenguaje:Español
Publicado: ST Bio-Life 2020
Materias:
MELATONINA
CORONAVIRUS
COVID-19
ACCIDENTE CEREBROVASCULAR
NEUROPROTECCION
NEUROLOGIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/10355
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-10355
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Español
topic MELATONINA
CORONAVIRUS
COVID-19
ACCIDENTE CEREBROVASCULAR
NEUROPROTECCION
NEUROLOGIA
spellingShingle MELATONINA
CORONAVIRUS
COVID-19
ACCIDENTE CEREBROVASCULAR
NEUROPROTECCION
NEUROLOGIA
Cardinali, Daniel Pedro
High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
topic_facet MELATONINA
CORONAVIRUS
COVID-19
ACCIDENTE CEREBROVASCULAR
NEUROPROTECCION
NEUROLOGIA
description Abstract: The therapeutic potential of melatonin as an agent to counteract the consequences of COVID-19 infections is due to its wide-ranging effects as a powerful antioxidant, anti-inflammatory, and immunostimulant, as well as to a possible antiviral action. In view of the recently reported evidence on the occurrence of neurological sequels in COVID-19-infected patients, another putative application of melatonin emerges based on its neuroprotective properties. In this manuscript a brief discussion of melatonin activity in animal models of ischemic and hemorrhagic stroke and the allometric calculations of the possible human equivalent doses are made. Based on the safety of melatonin, and in order to maximize its therapeutic opportunity, doses of 100 - 300 mg p.o. or i.v. are proposed.
format Artículo
author Cardinali, Daniel Pedro
author_facet Cardinali, Daniel Pedro
author_sort Cardinali, Daniel Pedro
title High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
title_short High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
title_full High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
title_fullStr High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
title_full_unstemmed High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
title_sort high doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection
publisher ST Bio-Life
publishDate 2020
url https://repositorio.uca.edu.ar/handle/123456789/10355
work_keys_str_mv AT cardinalidanielpedro highdosesofmelatoninasapotentialtherapeutictoolfortheneurologicsequelsofcovid19infection
bdutipo_str Repositorios
_version_ 1764820524338249730

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