Heart rate variability and falls in Huntington’s disease

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Abstract: Purpose: Huntington's disease (HD) patients have a high prevalence of falls. Autonomic nervous system dysfunction has been reported from the early stages of the disease. There is no evidence analyzing the relationship between heart rate variability (HRV) and falls in this population...

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Autores principales: Terroba-Chambi, Cinthia, Bruno, Veronica, Vigo, Daniel Eduardo, Merello, Marcelo
Formato: Artículo
Lenguaje:Inglés
Publicado: Springer Nature 2020
Materias:
ENFERMEDAD DE HUNTINGTON
SISTEMA NERVIOSO AUTONOMO
FRECUENCIA CARDIACA
TRASTORNOS DEL MOVIMIENTO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/10351
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-10351
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ENFERMEDAD DE HUNTINGTON
SISTEMA NERVIOSO AUTONOMO
FRECUENCIA CARDIACA
TRASTORNOS DEL MOVIMIENTO
spellingShingle ENFERMEDAD DE HUNTINGTON
SISTEMA NERVIOSO AUTONOMO
FRECUENCIA CARDIACA
TRASTORNOS DEL MOVIMIENTO
Terroba-Chambi, Cinthia
Bruno, Veronica
Vigo, Daniel Eduardo
Merello, Marcelo
Heart rate variability and falls in Huntington’s disease
topic_facet ENFERMEDAD DE HUNTINGTON
SISTEMA NERVIOSO AUTONOMO
FRECUENCIA CARDIACA
TRASTORNOS DEL MOVIMIENTO
description Abstract: Purpose: Huntington's disease (HD) patients have a high prevalence of falls. Autonomic nervous system dysfunction has been reported from the early stages of the disease. There is no evidence analyzing the relationship between heart rate variability (HRV) and falls in this population. This research aimed to evaluate the relationship between HRV and falls in HD. Methods: HD patients enrolled in a prospective study of Fear of Falling and falls were assessed using short-term HRV analyses and blood pressure measures in resting and standing states. Time-frequency domains and nonlinear parameters were calculated. Data regarding falls, the risk of falling (RoF) and disease-specific scales were collected at baseline and six-month follow-up. Results: Twenty HD patients were recruited. 35% of HD patients reported at least one fall (single fallers) and, 65% reported two or more falls (recurrent fallers) in the previous 12-months. At baseline, recurrent fallers had lower RMSSD-resting (root-mean-square-of-the-RR), higher LF/HF ratio (low/high frequency) in both states, and higher DFA-α1 parameter (short-term-detrended-fluctuation-analyses) in both states. This association was similar at a six-month follow-up for recurrent fallers showing lower RMSSD-resting and higher LF/HF-standing ratio than single fallers. Significant correlations were found between the number of falls, RMSSD-resting, and LF/HF-standing ratio. No differences were found between recurrent and single fallers for any blood pressure measures. Conclusions: The observed HRV pattern is consistent with a higher sympathetic prevalence associated with a higher RoF. Reduced parasympathetic HRV values predict being a recurrent faller at six-months of follow-up, independently of orthostatic phenomena in this population.
format Artículo
author Terroba-Chambi, Cinthia
Bruno, Veronica
Vigo, Daniel Eduardo
Merello, Marcelo
author_facet Terroba-Chambi, Cinthia
Bruno, Veronica
Vigo, Daniel Eduardo
Merello, Marcelo
author_sort Terroba-Chambi, Cinthia
title Heart rate variability and falls in Huntington’s disease
title_short Heart rate variability and falls in Huntington’s disease
title_full Heart rate variability and falls in Huntington’s disease
title_fullStr Heart rate variability and falls in Huntington’s disease
title_full_unstemmed Heart rate variability and falls in Huntington’s disease
title_sort heart rate variability and falls in huntington’s disease
publisher Springer Nature
publishDate 2020
url https://repositorio.uca.edu.ar/handle/123456789/10351
work_keys_str_mv AT terrobachambicinthia heartratevariabilityandfallsinhuntingtonsdisease
AT brunoveronica heartratevariabilityandfallsinhuntingtonsdisease
AT vigodanieleduardo heartratevariabilityandfallsinhuntingtonsdisease
AT merellomarcelo heartratevariabilityandfallsinhuntingtonsdisease
bdutipo_str Repositorios
_version_ 1764820524335104000

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