Individual cognitive and depressive traits associated with maternal versus paternal family history of Late-onset Alzheimer’s disease : proactive semantic interference versus standard neuropsychological assessments

Abstract: The main objective of this study was to assess cognitive and depressive manifestations associated with Alzheimer’s disease in middle-aged asymptomatic individuals with maternal versus paternal family history of the disease using standardly used neuropsychological measures and a novel cogni...

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Autores principales: Wilsona, Kathleen E., Abulafia, Carolina Andrea, Loewensteind, David A., Vigo, Daniel Eduardo, Sevlevere, Gustavo, Nemeroffd, Charles B., Villarreal, Mirta F., Guinjoan, Salvador M.
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier 2020
Materias:
ENFERMEDAD DE ALZHEIMER
DEPRESION
FUNCION COGNITIVA
EVALUACION PSICOLOGICA
NEUROPSICOLOGIA
TRATAMIENTO PSICOLOGICO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/10332
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-10332
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ENFERMEDAD DE ALZHEIMER
DEPRESION
FUNCION COGNITIVA
EVALUACION PSICOLOGICA
NEUROPSICOLOGIA
TRATAMIENTO PSICOLOGICO
spellingShingle ENFERMEDAD DE ALZHEIMER
DEPRESION
FUNCION COGNITIVA
EVALUACION PSICOLOGICA
NEUROPSICOLOGIA
TRATAMIENTO PSICOLOGICO
Wilsona, Kathleen E.
Abulafia, Carolina Andrea
Loewensteind, David A.
Vigo, Daniel Eduardo
Sevlevere, Gustavo
Nemeroffd, Charles B.
Villarreal, Mirta F.
Guinjoan, Salvador M.
Individual cognitive and depressive traits associated with maternal versus paternal family history of Late-onset Alzheimer’s disease : proactive semantic interference versus standard neuropsychological assessments
topic_facet ENFERMEDAD DE ALZHEIMER
DEPRESION
FUNCION COGNITIVA
EVALUACION PSICOLOGICA
NEUROPSICOLOGIA
TRATAMIENTO PSICOLOGICO
description Abstract: The main objective of this study was to assess cognitive and depressive manifestations associated with Alzheimer’s disease in middle-aged asymptomatic individuals with maternal versus paternal family history of the disease using standardly used neuropsychological measures and a novel cognitive stress test, the Loewenstein-Acevedo Scale for Semantic Interference and Learning (LASSI-L). We evaluated cognitive abilities in offspring of late-onset Alzheimer’s disease patients and a control group with no family history of dementia. Results showed lower cognitive performance in verbal episodic memory and semantic memory in participants with an Alzheimer’s parent, especially in individuals with a maternal family history of the disease. While the standardly used neuropsychological evaluations were sensitive to differences in cognition between those with a maternal history of the disease and the control group, the LASSI-L was sensitive to proactive semantic interference impairments in both groups with a paternal and maternal family history of the disease. Depressive symptoms may affect cognitive performance differently in individuals with a family history of Alzheimer’s disease compared to a control group, especially in individuals with a maternal history of the disease. This study highlights the value of semantic interference paradigms in early detection of Alzheimer’s and emphasizes the importance of studying maternal versus paternal transmission of the disease.
format Artículo
author Wilsona, Kathleen E.
Abulafia, Carolina Andrea
Loewensteind, David A.
Vigo, Daniel Eduardo
Sevlevere, Gustavo
Nemeroffd, Charles B.
Villarreal, Mirta F.
Guinjoan, Salvador M.
author_facet Wilsona, Kathleen E.
Abulafia, Carolina Andrea
Loewensteind, David A.
Vigo, Daniel Eduardo
Sevlevere, Gustavo
Nemeroffd, Charles B.
Villarreal, Mirta F.
Guinjoan, Salvador M.
author_sort Wilsona, Kathleen E.
title Individual cognitive and depressive traits associated with maternal versus paternal family history of Late-onset Alzheimer’s disease : proactive semantic interference versus standard neuropsychological assessments
title_short Individual cognitive and depressive traits associated with maternal versus paternal family history of Late-onset Alzheimer’s disease : proactive semantic interference versus standard neuropsychological assessments
title_full Individual cognitive and depressive traits associated with maternal versus paternal family history of Late-onset Alzheimer’s disease : proactive semantic interference versus standard neuropsychological assessments
title_fullStr Individual cognitive and depressive traits associated with maternal versus paternal family history of Late-onset Alzheimer’s disease : proactive semantic interference versus standard neuropsychological assessments
title_full_unstemmed Individual cognitive and depressive traits associated with maternal versus paternal family history of Late-onset Alzheimer’s disease : proactive semantic interference versus standard neuropsychological assessments
title_sort individual cognitive and depressive traits associated with maternal versus paternal family history of late-onset alzheimer’s disease : proactive semantic interference versus standard neuropsychological assessments
publisher Elsevier
publishDate 2020
url https://repositorio.uca.edu.ar/handle/123456789/10332
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