Therapeutical implications of melatonin in alzheimer’s and parkinson’s diseases

Abstract: Neurodegenerative diseases like Alzheimer’s disease (AD) and Parkinson’s disease (PD) are major health problems, and a growing recognition exists that efforts to prevent them must be undertaken by both governmental and nongovernmental organizations. In this context, the pineal product mela...

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Autores principales: Cardinali, Daniel Pedro, Vigo, Daniel Eduardo, Olivar, Natividad, Vida, María F., Brusco, Luis I.
Formato: Parte de libro
Lenguaje:Inglés
Publicado: Humana Press 2020
Materias:
NEURODEGENERACION
RADICALES LIBRES
ESTRES OXIDATIVO
ENVEJECIMIENTO
ENFERMEDAD DE ALZHEIMER
COGNICION
MELATONINA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/10188
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-10188
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic NEURODEGENERACION
RADICALES LIBRES
ESTRES OXIDATIVO
ENVEJECIMIENTO
ENFERMEDAD DE ALZHEIMER
COGNICION
MELATONINA
spellingShingle NEURODEGENERACION
RADICALES LIBRES
ESTRES OXIDATIVO
ENVEJECIMIENTO
ENFERMEDAD DE ALZHEIMER
COGNICION
MELATONINA
Cardinali, Daniel Pedro
Vigo, Daniel Eduardo
Olivar, Natividad
Vida, María F.
Brusco, Luis I.
Therapeutical implications of melatonin in alzheimer’s and parkinson’s diseases
topic_facet NEURODEGENERACION
RADICALES LIBRES
ESTRES OXIDATIVO
ENVEJECIMIENTO
ENFERMEDAD DE ALZHEIMER
COGNICION
MELATONINA
description Abstract: Neurodegenerative diseases like Alzheimer’s disease (AD) and Parkinson’s disease (PD) are major health problems, and a growing recognition exists that efforts to prevent them must be undertaken by both governmental and nongovernmental organizations. In this context, the pineal product melatonin has a promising significance because of its chronobiotic/cytoprotective properties. One of the features of advancing age is the gradual decrease in endogenous melatonin syn- thesis. A limited number of therapeutic trials have indicated that melatonin has a potential therapeutic value as a neuroprotective drug in the treatment of AD, mini- mal cognitive impairment (which may evolve to AD), and PD. Both in vitro and in vivo, melatonin prevented the neurodegeneration seen in experimental models of AD and PD. For these effects to occur, doses of melatonin about two orders of mag- nitude higher than those required to affect sleep and circadian rhythmicity are needed. More recently, attention has been focused on the development of potent melatonin analogs with prolonged effects which were employed in clinical trials in sleep-disturbed or depressed patients in doses considerably higher than those employed for melatonin. In view that the relative potencies of the analogs are higher than that of the natural compound, clinical trials employing melatonin in the range of 50–100 mg/day are needed to assess its therapeutic validity in neurodegenerative disorders.
format Parte de libro
author Cardinali, Daniel Pedro
Vigo, Daniel Eduardo
Olivar, Natividad
Vida, María F.
Brusco, Luis I.
author_facet Cardinali, Daniel Pedro
Vigo, Daniel Eduardo
Olivar, Natividad
Vida, María F.
Brusco, Luis I.
author_sort Cardinali, Daniel Pedro
title Therapeutical implications of melatonin in alzheimer’s and parkinson’s diseases
title_short Therapeutical implications of melatonin in alzheimer’s and parkinson’s diseases
title_full Therapeutical implications of melatonin in alzheimer’s and parkinson’s diseases
title_fullStr Therapeutical implications of melatonin in alzheimer’s and parkinson’s diseases
title_full_unstemmed Therapeutical implications of melatonin in alzheimer’s and parkinson’s diseases
title_sort therapeutical implications of melatonin in alzheimer’s and parkinson’s diseases
publisher Humana Press
publishDate 2020
url https://repositorio.uca.edu.ar/handle/123456789/10188
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