Melatonin signaling as a link between sleep and circadian biology : practical implications

Abstract: Normal circadian rhythms are synchronized to a regular 24 h environmental light-dark cycle. Both the suprachiasmatic nucleus (SCN) and melatonin are essential for this adaptation. Melatonin exerts its chronophysiological action in part by acting through specific membrane receptors (MT1, MT...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Cardinali, Daniel Pedro, Brown, Gregory M.
Formato: Parte de libro
Lenguaje:Inglés
Publicado: Apple Academic Press 2020
Materias:
MELATONINA
SUEÑO
RITMO CIRCADIANO
TRASTORNOS DEL SUEÑO
BENZODIAZEPINAS
ENFERMEDAD DE ALZHEIMER
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/10185
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-10185
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic MELATONINA
SUEÑO
RITMO CIRCADIANO
TRASTORNOS DEL SUEÑO
BENZODIAZEPINAS
ENFERMEDAD DE ALZHEIMER
spellingShingle MELATONINA
SUEÑO
RITMO CIRCADIANO
TRASTORNOS DEL SUEÑO
BENZODIAZEPINAS
ENFERMEDAD DE ALZHEIMER
Cardinali, Daniel Pedro
Brown, Gregory M.
Melatonin signaling as a link between sleep and circadian biology : practical implications
topic_facet MELATONINA
SUEÑO
RITMO CIRCADIANO
TRASTORNOS DEL SUEÑO
BENZODIAZEPINAS
ENFERMEDAD DE ALZHEIMER
description Abstract: Normal circadian rhythms are synchronized to a regular 24 h environmental light-dark cycle. Both the suprachiasmatic nucleus (SCN) and melatonin are essential for this adaptation. Melatonin exerts its chronophysiological action in part by acting through specific membrane receptors (MT1, MT2), which have been identified in SCN cells as well as in several neural and non-neural tissues. Both receptors have been cloned and share general features with other G protein linked receptors. Melatonin also exerts direct effects on intracellular proteins, such as calmodulin or tubulin, has strong free radical scavenger properties, which are non-receptor mediated, is an effective mitochondrial protector and may interact with proteasome to affect intracellular physiology. Within the SCN, melatonin reduces neuronal activity in a time-dependent manner. The disruption of these circadian mechanisms causes a number of sleep disorders known as circadian rhythm sleep disorders (CRSDs). CRSDs include delayed or advanced sleep phase syndromes; non-24 h sleep-wake rhythm disorder, time zone change syndrome (“jet lag”) and shift work sleep disorder. Disturbances in the circadian phase position of plasma melatonin levels have been found in all these disorders. In addition, comorbidity of severe circadian alterations with neurodegenerative diseases like Alzheimer’s disease (AD) has been documented. Currently there is sufficient evidence to implicate endogenous melatonin as an important mediator in CRSD pathophysiology. The documented efficacy of melatonin to reduce chronic benzodiazepine/Z drug use in insomnia patients is also discussed.
format Parte de libro
author Cardinali, Daniel Pedro
Brown, Gregory M.
author_facet Cardinali, Daniel Pedro
Brown, Gregory M.
author_sort Cardinali, Daniel Pedro
title Melatonin signaling as a link between sleep and circadian biology : practical implications
title_short Melatonin signaling as a link between sleep and circadian biology : practical implications
title_full Melatonin signaling as a link between sleep and circadian biology : practical implications
title_fullStr Melatonin signaling as a link between sleep and circadian biology : practical implications
title_full_unstemmed Melatonin signaling as a link between sleep and circadian biology : practical implications
title_sort melatonin signaling as a link between sleep and circadian biology : practical implications
publisher Apple Academic Press
publishDate 2020
url https://repositorio.uca.edu.ar/handle/123456789/10185
work_keys_str_mv AT cardinalidanielpedro melatoninsignalingasalinkbetweensleepandcircadianbiologypracticalimplications
AT browngregorym melatoninsignalingasalinkbetweensleepandcircadianbiologypracticalimplications
bdutipo_str Repositorios
_version_ 1764820524036259840

Ejemplares similares